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European Brown Hare Syndrome Virus
European brown hare syndrome (EBHS) is a highly contagious viral disease that affects hares and some cottontail rabbits, though it is most frequently found in the European hare (''Lepus europaeus''). It is caused by the lagovirus known as ''Lagovirus europaeus'', formerly European brown hare syndrome virus. The disease manifests clinically as liver damage, but most hares that contract the virus die within 2-7 days before clinical signs are visible, following a period of anorexia and depression. Discovery European brown hare syndrome virus was first described in the 1980s and was noted as closely related to rabbit hemorrhagic disease Rabbit hemorrhagic disease (RHD), also known as viral hemorrhagic disease (VHD), is a highly infectious and lethal form of viral hepatitis that affects European rabbits. Some viral strains also affect hares and cottontail rabbits. Mortality rat ... (RHD) virus, another calcivirus that causes severe viral hepatitis in European rabbits. A v ...
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Contagious Disease
A contagious disease is an infectious disease that can be spread rapidly in several ways, including direct contact, indirect contact, and droplet contact. These diseases are caused by organisms such as parasites, bacteria, fungi, and viruses. While many types of organisms live on the human body and are usually harmless, these organisms can sometimes cause disease. Some common infectious diseases are influenza, COVID-19, ebola, hepatitis, HIV/AIDS, Human papillomavirus infection, Polio, and Zika virus. A disease is often known to be contagious before medical science discovers its causative agent. Koch's postulates, which were published at the end of the 19th century, were the standard for the next 100 years or more, especially with diseases caused by bacteria. Microbial pathogenesis attempts to account for diseases caused by a virus. Historical meaning Originally, the term referred to a ''contagion'' or disease transmissible only by direct physical contact. In the mode ...
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Hare
Hares and jackrabbits are mammals belonging to the genus ''Lepus''. They are herbivores and live Solitary animal, solitarily or in pairs. They nest in slight depressions called forms, and their young are precociality, able to fend for themselves shortly after birth. The genus includes the largest Lagomorpha, lagomorphs. Most are fast runners with long, powerful hind legs, and large ears that dissipate body heat. Hare species are native to Africa, Eurasia and North America. A hare less than one year old is called a "leveret". Members of the ''Lepus'' genus are considered true hares, distinguishing them from rabbits which make up the rest of the Leporidae family. However, there are five leporid species with "hare" in their common names which are not considered true hares: the hispid hare (''Caprolagus hispidus''), and four species known as red rock hares (''Pronolagus''). Conversely, several ''Lepus'' species are called "jackrabbits", but classed as hares rather than rabbits. The p ...
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Cottontail Rabbit
Cottontail rabbits are in the ''Sylvilagus'' genus, which is in the family Leporidae. They are found in the Americas. Most ''Sylvilagus'' species have stub tails with white undersides that show when they retreat, giving them their characteristic name. However, this feature is not present in all ''Sylvilagus'', nor is it unique to the genus. However their fur ranges from brown to gray and changes throughout the year, depending on the season. The genus is widely distributed across North America, Central America, and northern and central South America, though most species are confined to particular regions. Most species live in nests called forms, and all have altricial young. They often live on the edges of fields, farms, and other open spaces far from highly populated areas. But sometimes they make their nests in yards and parks near more people. An adult female averages three litters per year, which can be born in any season. Occurrence and litter size depend on several factors ...
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Lagovirus
''Lagovirus'' is a genus of viruses, in the family ''Caliciviridae''. Lagomorphs serve as natural hosts. There are two species in this genus. Diseases associated with this genus include: necrotizing hepatitis leading to fatal hemorrhages. Taxonomy The genus contains the following species: * '' European brown hare syndrome virus'' * '' Rabbit hemorrhagic disease virus'' Virion properties Morphology Virions consist of a capsid. The capsid is not enveloped, round with T=3 icosahedral symmetry. The isometric capsid has a diameter of 35–39 nm. Particles with T=1 symmetry, composed of 60 capsid proteins are also observed, which have diameter of about 15 nm. Capsids appear round to hexagonal in outline. The capsid surface structure reveals a regular pattern with distinctive features. The capsomer arrangement is clearly visible. Capsid with 32 cup-shaped depressions. Life cycle Viral replication is cytoplasmic. Entry into the host cell is achieved by attachment to host re ...
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Clinical Symptom
Signs and symptoms are diagnostic indications of an illness, injury, or condition. Signs are objective and externally observable; symptoms are a person's reported subjective experiences. A sign for example may be a higher or lower temperature than normal, raised or lowered blood pressure or an abnormality showing on a medical scan. A symptom is something out of the ordinary that is experienced by an individual such as feeling feverish, a headache or other pains in the body, which occur as the body's immune system fights off an infection. Signs and symptoms Signs A medical sign is an objective observable indication of a disease, injury, or medical condition that may be detected during a physical examination. These signs may be visible, such as a rash or bruise, or otherwise detectable such as by using a stethoscope or taking blood pressure. Medical signs, along with symptoms, help in forming a diagnosis. Some examples of signs are nail clubbing of either the fingernails or toe ...
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Liver Disease
Liver disease, or hepatic disease, is any of many diseases of the liver. If long-lasting it is termed chronic liver disease. Although the diseases differ in detail, liver diseases often have features in common. Liver diseases File:Ground glass hepatocytes high mag cropped 2.jpg, Ground glass hepatocytes File:Primary biliary cirrhosis intermed mag much cropping.jpg, Primary biliary cirrhosis File:Buddchiari2.PNG, Budd–Chiari syndrome File:Non-alcoholic_fatty_liver_disease1.jpg, Micrograph of non-alcoholic fatty liver disease There are more than a hundred different liver diseases. Some of the most common are: * Fascioliasis, a parasitic infection of liver caused by a liver fluke of the genus '' FascioIa'', mostly '' FascioIa hepatica''. * Hepatitis, inflammation of the liver, is caused by various viruses ( viral hepatitis) also by some liver toxins (e.g. alcoholic hepatitis), autoimmunity ( autoimmune hepatitis) or hereditary conditions. * Alcoholic liver disease is a h ...
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Eating Disorder
An eating disorder is a mental disorder defined by abnormal eating behaviors that adversely affect a person's health, physical or mental health, mental health. These behaviors may include eating too much food or too little food. Types of eating disorders include binge eating disorder, where the person suffering keeps eating large amounts in a short period of time typically while not being hungry; anorexia nervosa, where the person has an intense fear of gaining weight and restricts food or overexercises to manage this fear; bulimia nervosa, where individuals eat a large quantity (binging) then try to rid themselves of the food (purging); pica (disorder), pica, where the patient eats non-food items; rumination syndrome, where the patient regurgitation (digestion), regurgitates undigested or minimally digested food; avoidant/restrictive food intake disorder (ARFID), where people have a reduced or selective food intake due to some psychological reasons; and a group of other specifi ...
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Depression (mood)
Depression is a mental state of low Mood (psychology), mood and aversion to activity. It affects about 3.5% of the global population, or about 280 million people worldwide, as of 2020. Depression affects a person's thoughts, behavior, feelings, and subjective well-being, sense of well-being. The pleasure or joy that a person gets from certain experiences is reduced, and the afflicted person often experiences a loss of motivation or interest in those activities. People with depression may experience sadness, feelings of dejection or hopelessness, difficulty in thinking and concentration, or a significant change in appetite or time spent sleeping; Suicidal ideation, suicidal thoughts can also be experienced. Depression can have multiple, sometimes overlapping, origins. Depression can be a symptom of some mood disorders, some of which are also commonly called ''depression'', such as major depressive disorder, bipolar disorder and dysthymia. Additionally, depression can be a norm ...
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Rabbit Hemorrhagic Disease
Rabbit hemorrhagic disease (RHD), also known as viral hemorrhagic disease (VHD), is a highly infectious and lethal form of viral hepatitis that affects European rabbits. Some viral strains also affect hares and cottontail rabbits. Mortality rates generally range from 70 to 100 percent. The disease is caused by strains of ''rabbit hemorrhagic disease virus'' (RHDV), a lagovirus in the family ''Caliciviridae''. Rabbit hemorrhagic disease virus ''Rabbit hemorrhagic disease virus'' (RHDV) is a virus in the genus ''Lagovirus'' and the family ''Caliciviridae''. It is a nonenveloped virus with a diameter around 35–40 nm, icosahedral symmetry, and a linear positive-sense RNA genome of 6.4–8.5 kb. RHDV causes a generalized infection in rabbits that is characterized by necrosis of the liver, disseminated intravascular coagulation, and rapid death. Division into serotypes has been defined by a lack of cross-neutralization using specific antisera. Rabbit lagoviruses also inclu ...
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Caliciviridae
The ''Caliciviridae'' are a family of "small round structured" viruses, members of Class IV of the Baltimore scheme. Caliciviridae bear resemblance to enlarged picornavirus and was formerly a separate genus within the picornaviridae. They are positive-sense, single-stranded RNA which is not segmented. Thirteen species are placed in this family, divided among eleven genera. Diseases associated with this family include feline calicivirus (respiratory disease), rabbit hemorrhagic disease virus (often fatal hepatitis), and Norwalk group of viruses (gastroenteritis). Caliciviruses naturally infect vertebrates, and have been found in a number of organisms such as humans, cattle, pigs, cats, chickens, reptiles, dolphins and amphibians. The caliciviruses have a simple construction and are not enveloped. The capsid appears hexagonal/ spherical and has icosahedral symmetry (T=1 or T=3) with a diameter of 35–39 nm. Caliciviruses are not very well studied because until 2010, they ...
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European Rabbit
The European rabbit (''Oryctolagus cuniculus'') or coney is a species of rabbit native to the Iberian Peninsula (Spain, Portugal and Andorra) and southwestern France. It is the only extant species in the genus ''Oryctolagus''. The European rabbit has faced a population decline in its native range due to myxomatosis, rabbit haemorrhagic disease, overhunting and habitat loss. Outside of its native range, it is known as an invasive species, as it has been introduced to countries on all continents with the exception of Antarctica, often with devastating effects on local biodiversity due to a lack of predators. The average adult European rabbit is in length, and can weigh , though size and weight vary with habitat and diet. Its distinctive ears can measure up to from the Occipital bone, occiput. Due to the European rabbit's history of domestication, selective breeding, and introduction to non-native habitats, feral European rabbits across the world display a wide variety of Morpho ...
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