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Dynamic Nuclear Polarisation
Dynamic nuclear polarization (DNP) is one of several Hyperpolarization (physics), hyperpolarization methods developed to enhance the sensitivity of nuclear magnetic resonance (NMR) spectroscopy. While an essential analytical tool with applications in several fields, NMR’s low sensitivity poses major limitations to analyzing samples with low concentrations and limited masses and volumes.Abhyankar, N., & Szalai, V. (2021). Challenges and advances in the application of dynamic nuclear polarization to liquid-state NMR spectroscopy. ''The Journal of Physical Chemistry B'', ''125''(20), 5171–5190. https://doi.org/10.1021/acs.jpcb.0c10937 This low sensitivity is due to the relatively low nuclear gyromagnetic ratios (''γn'') of NMR active nuclei (1H, 13C, 15N, etc.) as well as the low natural abundance of certain nuclei.Plainchont, B., Berruyer, P., Dumez, J.-N., Jannin, S., & Giraudeau, P. (2018). Dynamic nuclear polarization opens new perspectives for NMR spectroscopy in Analytica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyperpolarization (physics)
Hyperpolarization is the spin polarization of the atomic nuclei of a material in a magnetic field far beyond thermal equilibrium conditions determined by the Boltzmann distribution. It can be applied to gases such as and , and small molecules where the polarization levels can be enhanced by a factor of 104–105 above thermal equilibrium levels. Hyperpolarized noble gases are typically used in magnetic resonance imaging (MRI) of the lungs. Hyperpolarized small molecules are typically used for ''in vivo'' metabolic imaging. For example, a hyperpolarized metabolite can be injected into animals or patients and the metabolic conversion can be tracked in real-time. Other applications include determining the function of the neutron spin-structures by scattering polarized electrons from a very polarized target (3He), surface interaction studies, and neutron polarizing experiments. Spin-exchange optical pumping Introduction Spin exchange optical pumping (SEOP) is one of several hype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Paramagnetism
Paramagnetism is a form of magnetism whereby some materials are weakly attracted by an externally applied magnetic field, and form internal, induced magnetic fields in the direction of the applied magnetic field. In contrast with this behavior, diamagnetic materials are repelled by magnetic fields and form induced magnetic fields in the direction opposite to that of the applied magnetic field. Paramagnetic materials include most chemical elements and some compounds; they have a relative magnetic permeability slightly greater than 1 (i.e., a small positive magnetic susceptibility) and hence are attracted to magnetic fields. The magnetic moment induced by the applied field is linear in the field strength and rather weak. It typically requires a sensitive analytical balance to detect the effect and modern measurements on paramagnetic materials are often conducted with a SQUID magnetometer. Paramagnetism is due to the presence of unpaired electrons in the material, so most atom ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Von Neumann Equation
In quantum mechanics, a density matrix (or density operator) is a matrix used in calculating the probabilities of the outcomes of measurements performed on physical systems. It is a generalization of the state vectors or wavefunctions: while those can only represent pure states, density matrices can also represent mixed states. These arise in quantum mechanics in two different situations: # when the preparation of a system can randomly produce different pure states, and thus one must deal with the statistics of possible preparations, and # when one wants to describe a physical system that is entangled with another, without describing their combined state. This case is typical for a system interacting with some environment (e.g. decoherence). In this case, the density matrix of an entangled system differs from that of an ensemble of pure states that, combined, would give the same statistical results upon measurement. Density matrices are thus crucial tools in areas of quantum mecha ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Perturbation Theory
In mathematics and applied mathematics, perturbation theory comprises methods for finding an approximate solution to a problem, by starting from the exact solution of a related, simpler problem. A critical feature of the technique is a middle step that breaks the problem into "solvable" and "perturbative" parts. In regular perturbation theory, the solution is expressed as a power series in a small parameter The first term is the known solution to the solvable problem. Successive terms in the series at higher powers of \varepsilon usually become smaller. An approximate 'perturbation solution' is obtained by truncating the series, often keeping only the first two terms, the solution to the known problem and the 'first order' perturbation correction. Perturbation theory is used in a wide range of fields and reaches its most sophisticated and advanced forms in quantum field theory. Perturbation theory (quantum mechanics) describes the use of this method in quantum mechanics. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hyperfine Coupling
In atomic physics, hyperfine structure is defined by small shifts in otherwise degenerate electronic energy levels and the resulting splittings in those electronic energy levels of atoms, molecules, and ions, due to electromagnetic multipole interaction between the nucleus and electron clouds. In atoms, hyperfine structure arises from the energy of the nuclear magnetic dipole moment interacting with the magnetic field generated by the electrons and the energy of the nuclear electric quadrupole moment in the electric field gradient due to the distribution of charge within the atom. Molecular hyperfine structure is generally dominated by these two effects, but also includes the energy associated with the interaction between the magnetic moments associated with different magnetic nuclei in a molecule, as well as between the nuclear magnetic moments and the magnetic field generated by the rotation of the molecule. Hyperfine structure contrasts with ''fine structure'', which results ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Pence Slichter
Charles Pence Slichter (January 21, 1924 – February 19, 2018) was an American physicist, best known for his work on nuclear magnetic resonance and superconductivity. He was awarded the 2007 National Medal of Science "for establishing nuclear magnetic resonance as a powerful tool to reveal the fundamental molecular properties of liquids and solids. His inspired teaching has led generations of physicists and chemists to develop a host of modern technologies in condensed matter physics, chemistry, biology and medicine." Birth and education Slichter was born in 1924 in Ithaca, New York. He attended Harvard University, where in 1949 received his Ph.D. under the supervision of Edward Purcell. Career Slichter was a professor of physics and chemistry at the University of Illinois at Urbana-Champaign from 1949 until his retirement in 2006. He spent one sabbatical semester (Spring 1961) as Morris Loeb Lecturer at Harvard University. The lectures he gave there formed the nucleus of h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Felix Bloch
Felix Bloch (; ; 23 October 1905 – 10 September 1983) was a Swiss-American physicist who shared the 1952 Nobel Prize in Physics with Edward Mills Purcell "for their development of new methods for nuclear magnetic precision measurements and discoveries in connection therewith".Sohlman, M (Ed.) ''Nobel Foundation directory 2003.'' Vastervik, Sweden: AB CO Ekblad; 2003. Bloch made fundamental theoretical contributions to the understanding of ferromagnetism and electron behavior in Bravais lattice, crystal lattices. He is also considered one of the developers of nuclear magnetic resonance. Biography Early life, education, and family Bloch was born in Zürich, Switzerland to Jewish parents Gustav and Agnes Bloch. Gustav Bloch, his father, was financially unable to attend university and worked as a wholesale grain dealer in Zürich. Gustav moved to Zürich from Moravia in 1890 to become a Swiss citizen. Their first child was a girl born in 1902 while Felix was born three years lat ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Norman Ramsey
Norman Foster Ramsey Jr. (August 27, 1915 – November 4, 2011) was an American physicist who was awarded the 1989 Nobel Prize in Physics for the invention of the separated oscillatory field method (see Ramsey interferometry), which had important applications in the construction of atomic clocks. A physics professor at Harvard University for most of his career, Ramsey also held several posts with such government and international agencies as NATO and the United States Atomic Energy Commission. Among his other accomplishments are helping to found the United States Department of Energy's Brookhaven National Laboratory and Fermilab. Early life Norman Foster Ramsey Jr. was born in Washington, D.C., on August 27, 1915, to Minna Bauer Ramsey and Norman Foster Ramsey. His mother was the daughter of German immigrants and an instructor at the University of Kansas. His father, who was of Scottish descent, was a 1905 graduate of the United States Military Academy at West Point and an offi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Overhauser
Albert W. Overhauser (August 17, 1925 – December 10, 2011) was an American physicist and a member of the National Academy of Sciences. He is best known for his theory of the Overhauser effect in nuclear magnetic resonance. The Overhauser effect was the first example of dynamic nuclear polarization whereby spin polarization is transferred from unpaired electrons in paramagnetic metals to nuclei resulting in a dramatic increase in their NMR intensity. The Nuclear Overhauser Effect, which follows the same mechanism, is also widely used in nuclear magnetic resonance and formed the basis for early protein structure determinations, for which Kurt Wüthrich was ultimately awarded the Nobel prize in Chemistry. Life Born in San Diego, California, Overhauser attended high school in San Francisco at Lick-Wilmerding High School and began his undergraduate work at the University of California, Berkeley in 1942. He interrupted his studies during World War II for a two-year stint in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Journal Of Chemical Physics
''The Journal of Chemical Physics'' is a scientific journal published by the American Institute of Physics that carries research papers on chemical physics."About the Journal" from the ''Journal of Chemical Physics'' website. Two volumes, each of 24 issues, are published annually. It was established in 1933 when '''' editors refused to publish theoretical works. The editors have been: *2019–present: Tim Lian *2008–2018: Marsha I. Lester *2007–2008: [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Physical Review
''Physical Review'' is a peer-reviewed scientific journal. The journal was established in 1893 by Edward Nichols. It publishes original research as well as scientific and literature reviews on all aspects of physics. It is published by the American Physical Society (APS). The journal is in its third series, and is split in several sub-journals each covering a particular field of physics. It has a sister journal, '' Physical Review Letters'', which publishes shorter articles of broader interest. History ''Physical Review'' commenced publication in July 1893, organized by Cornell University professor Edward Nichols and helped by the new president of Cornell, J. Gould Schurman. The journal was managed and edited at Cornell in upstate New York from 1893 to 1913 by Nichols, Ernest Merritt, and Frederick Bedell. The 33 volumes published during this time constitute ''Physical Review Series I''. The American Physical Society (APS), founded in 1899, took over its publicati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nuclear Overhauser Effect
The nuclear Overhauser effect (NOE) is the transfer of spin polarization, nuclear spin polarization from one population of Spin (physics), spin-active nuclei (e.g. 1H, 13C, 15N etc.) to another via Relaxation (NMR), cross-relaxation. A phenomenological definition of the NOE in nuclear magnetic resonance spectroscopy (NMR) is the change in the integrated intensity (positive or negative) of one NMR resonance that occurs when another is saturated by irradiation with an Radio frequency, RF field. The change in resonance intensity of a nucleus is a consequence of the nucleus being close in space to those directly affected by the RF perturbation. The NOE is particularly important in the assignment of NMR resonances, and the elucidation and confirmation of the structures or configurations of organic and biological molecules. The 1H two-dimensional NOE spectroscopy (NOESY) experiment and its extensions are important tools to identify stereochemistry of proteins and other biomolecules in sol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
