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Duesberg Hypothesis
The Duesberg hypothesis is the claim that AIDS is not caused by HIV, but, instead, that AIDS is caused by noninfectious factors such as recreational and pharmaceutical drug use and that HIV is merely a harmless passenger virus. The hypothesis was popularized by University of California, Berkeley professor Peter Duesberg, from whom the hypothesis gets its name. The scientific consensus is that the Duesberg hypothesis is incorrect and that HIV is the cause of AIDS. The most prominent supporters of the hypothesis are Duesberg himself, biochemist and vitamin proponent David Rasnick and journalist Celia Farber. The scientific community generally contends that Duesberg's arguments in favor of the hypothesis are the result of cherry-picking predominantly outdated scientific data and selectively ignoring evidence that demonstrates HIV's role in causing AIDS. Role of legal and illegal drug use Duesberg argues that there is a statistical correlation between trends in recreational drug us ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AIDS
Human immunodeficiency virus infection and acquired immunodeficiency syndrome (HIV/AIDS) is a spectrum of conditions caused by infection with the human immunodeficiency virus (HIV), a retrovirus. Following initial infection an individual may not notice any symptoms, or may experience a brief period of influenza-like illness. Typically, this is followed by a prolonged incubation period with no symptoms. If the infection progresses, it interferes more with the immune system, increasing the risk of developing common infections such as tuberculosis, as well as other opportunistic infections, and tumors which are rare in people who have normal immune function. These late symptoms of infection are referred to as acquired immunodeficiency syndrome (AIDS). This stage is often also associated with unintended weight loss. HIV is spread primarily by unprotected sex (including anal and vaginal sex), contaminated blood transfusions, hypodermic needles, and from mother to ch ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fallacy
A fallacy is the use of invalid or otherwise faulty reasoning, or "wrong moves," in the construction of an argument which may appear stronger than it really is if the fallacy is not spotted. The term in the Western intellectual tradition was introduced in the Aristotelian '' De Sophisticis Elenchis''. Some fallacies may be committed intentionally to manipulate or persuade by deception. Others may be committed unintentionally because of human limitations such as carelessness, cognitive or social biases and ignorance, or, potentially, as the inevitable consequence of the limitations of language and understanding of language. This includes ignorance of the right reasoning standard, but also ignorance of relevant properties of the context. For instance, the soundness of legal arguments depends on the context in which the arguments are made. Fallacies are commonly divided into "formal" and "informal." A formal fallacy is a flaw in the structure of a deductive argument wh ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
National Institute Of Allergy And Infectious Diseases
The National Institute of Allergy and Infectious Diseases (NIAID, ) is one of the 27 institutes and centers that make up the National Institutes of Health (NIH), an agency of the United States Department of Health and Human Services (HHS). NIAID's mission is to conduct basic and applied research to better understand, treat, and prevent infectious, immunologic, and allergic diseases. NIAID has on-campus laboratories in Maryland and Hamilton, Montana, and funds research conducted by scientists at institutions in the United States and throughout the world. NIAID also works closely with partners in academia, industry, government, and non-governmental organizations in multifaceted and multidisciplinary efforts to address emerging health challenges such as the H1N1/09 pandemic and the COVID-19 pandemic. History NIAID traces its origins to a small laboratory established in 1887 at the Marine Hospital on Staten Island, New York (now the Bayley Seton Hospital). Officials of the Mar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Women's Interagency HIV Study
The Women's Interagency HIV Study (WIHS) was established in August 1993 to investigate the impact and progression of HIV disease in women. he WIHS enrolls both HIV-positive and HIV-negative women. The core portion of the study includes a detailed and structured interview, physical and gynecologic examination, and laboratory testing. The WIHS participants are also asked to enroll in various sub-studies, such as cardiovascular, metabolic, musculoskeletal, and neurocognition. New proposals for WIHS sub-studies are submitted for approval by various scientific investigators from around the world. Funding The WIHS is funded primarily by the National Institute of Allergy and Infectious Diseases (NIAID), with additional co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), the National Cancer Institute (NCI), the National Institute on Drug Abuse (NIDA), and the National Institute on Mental Health (NIMH). Targeted supplemental fundin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Multicenter AIDS Cohort Study
The Multicenter AIDS Cohort Study (MACS) is an ongoing cohort study involving over 6,000 men, including both those infected with HIV, as well as HIV-negative men. The MACS has four main sites: Baltimore, Pittsburgh, Los Angeles, and Chicago. The Los Angeles component of the MACS is called the Los Angeles Mens Study or LAMS. LAMS affiliated with UCLA and is supervised by Dr Roger Detels, MD & John Oishi. The study, a program of the Division of Acquired Immunodeficiency Syndrome, has been ongoing since 1984 and has resulted in over 1,000 scientific publications. It helped to establish that AIDS was the result of a viral illness and how HIV was spread. Participants were quizzed in detail about their sexual behavior. "They ask you for numbers, how many times did you do what." Some participants who had many sexual partners were not infected, and this led to the realization that some people had genetic resistance to the virus. See also * Clinical trial Clinical trials are prospect ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Seropositive
Serostatus refers to the presence or absence of a serological marker in the blood. The presence of detectable levels of a specific marker within the serum is considered seropositivity, while the absence of such levels is considered seronegativity. HIV/AIDS The term serostatus is commonly used in HIV/AIDS prevention efforts. In the late 20th and early 21st centuries, social advocacy has emphasized the importance of learning one's HIV/AIDS serostatus in an effort to curtail the spread of the disease. Autoimmune disease Researchers have investigated the effects of autoantibody serostatus on autoimmune disease presentation. Study of seronegative patient populations has led to the identification of additional autoantibodies that could potentially help with diagnosis. See also * Seroconversion * Correlates of immunity Correlates of immunity or correlates of protection to a virus or other infectious pathogen are measurable signs that a person (or other potential host) is immune, in the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Homosexuality
Homosexuality is romantic attraction, sexual attraction, or sexual behavior between members of the same sex or gender. As a sexual orientation, homosexuality is "an enduring pattern of emotional, romantic, and/or sexual attractions" to people of the same sex. It "also refers to a person's sense of identity based on those attractions, related behaviors, and membership in a community of others who share those attractions." Along with bisexuality and heterosexuality, homosexuality is one of the three main categories of sexual orientation within the heterosexual–homosexual continuum. Scientists do not yet know the exact cause of sexual orientation, but they theorize that it is caused by a complex interplay of genetic, hormonal, and environmental influences and do not view it as a choice. Although no single theory on the cause of sexual orientation has yet gained widespread support, scientists favor biologically based theories. There is considerably more evidence supp ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Prospective Study
A prospective cohort study is a longitudinal cohort study that follows over time a group of similar individuals ( cohorts) who differ with respect to certain factors under study, to determine how these factors affect rates of a certain outcome. For example, one might follow a cohort of middle-aged truck drivers who vary in terms of smoking habits, to test the hypothesis that the 20-year incidence rate of lung cancer will be highest among heavy smokers, followed by moderate smokers, and then nonsmokers. The prospective study is important for research on the etiology of diseases and disorders. The distinguishing feature of a prospective cohort study is that at the time that the investigators begin enrolling subjects and collecting baseline exposure information, none of the subjects have developed any of the outcomes of interest. After baseline information is collected, subjects in a prospective cohort study are then followed "longitudinally," i.e. over a period of time, usually for ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2019 '' Journal Citation Reports'' (with an ascribed impact factor of 42.778), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in autumn 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander Macmillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the journal; ''Nature'' redoubled its efforts in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sexual Promiscuity
Promiscuity is the practice of engaging in sexual activity frequently with different partners or being indiscriminate in the choice of sexual partners. The term can carry a moral judgment. A common example of behavior viewed as promiscuous by many cultures is the one-night stand, and its frequency is used by researchers as a marker for promiscuity. What sexual behavior is considered promiscuous varies between cultures, as does the prevalence of promiscuity. Different standards are often applied to different genders and civil statutes. Feminists have traditionally argued a significant double standard exists between how men and women are judged for promiscuity. Historically, stereotypes of the promiscuous woman have tended to be pejorative, such as "the slut" or "the harlot", while male stereotypes have been more varied, some expressing approval, such as "the stud" or "the player", while others imply societal deviance, such as "the womanizer" or "the philanderer". A scientific study ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Highly Active Antiretroviral Therapy
The management of HIV/AIDS normally includes the use of multiple antiretroviral drugs as a strategy to control HIV infection. There are several classes of antiretroviral agents that act on different stages of the HIV life-cycle. The use of multiple drugs that act on different viral targets is known as highly active antiretroviral therapy (HAART). HAART decreases the patient's total burden of HIV, maintains function of the immune system, and prevents opportunistic infections that often lead to death. HAART also prevents the transmission of HIV between serodiscordant same sex and opposite sex partners so long as the HIV-positive partner maintains an undetectable viral load. Treatment has been so successful that in many parts of the world, HIV has become a chronic condition in which progression to AIDS is increasingly rare. Anthony Fauci, head of the United States National Institute of Allergy and Infectious Diseases, has written, "With collective and resolute action now and a steadfa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protease Inhibitor (pharmacology)
Protease inhibitors (PIs) are medications that act by interfering with enzymes that cleave proteins. Some of the most well known are antiviral drugs widely used to treat HIV/AIDS and hepatitis C. These protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking proteolytic cleavage of protein precursors that are necessary for the production of infectious viral particles. Protease inhibitors that have been developed and are currently used in clinical practice include: * Antiretroviral HIV-1 protease inhibitors—class stem ** Amprenavir ** Atazanavir ** Darunavir ** Fosamprenavir ** Indinavir ** Lopinavir ** Nelfinavir ** Ritonavir ** Saquinavir ** Tipranavir * Hepatitis C virus NS3/ 4A protease inhibitors—class stem ** Asunaprevir ** Boceprevir ** Grazoprevir ** Glecaprevir ** Paritaprevir ** Simeprevir ** Telaprevir * Severe acute respiratory syndrome coronavirus 2 3-chymotrypsin-like prote ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
