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Dolichol Monophosphate
Dolichol monophosphate is a phosphate ester of dolichol Dolichol refers to any of a group of long-chain mostly unsaturated organic compounds that are made up of varying numbers of isoprene units terminating in an α-saturated isoprenoid group, containing an alcohol functional group. Functions Dolicho .... See also * Dolichyl-phosphatase * Dolichyl-phosphate beta-D-mannosyltransferase * DPM1 Phospholipids {{organic-compound-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phosphate Ester
In organic chemistry, organophosphates (also known as phosphate esters, or OPEs) are a class of organophosphorus compounds with the general structure , a central phosphate molecule with alkyl or aromatic substituents. They can be considered as esters of phosphoric acid. Organophosphates are best known for their use as pesticides. Like most functional groups, organophosphates occur in a diverse range of forms, with important examples including key biomolecules such as DNA, RNA and ATP, as well as many insecticides, herbicides, nerve agents and flame retardants. OPEs have been widely used in various products as flame retardants, plasticizers, and performance additives to engine oil. The low cost of production and compatibility to diverse polymers made OPEs to be widely used in industry including textile, furniture, electronics as plasticizers and flame retardants. These compounds are added to the final product physically rather than by chemical bond. Due to this, OPEs leak into ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dolichol
Dolichol refers to any of a group of long-chain mostly unsaturated organic compounds that are made up of varying numbers of isoprene units terminating in an α-saturated isoprenoid group, containing an alcohol functional group. Functions Dolichols play a role in the post-translational modification of proteins known as ''N''-glycosylation in the form of dolichol phosphate. Dolichols function as a membrane anchor for the formation of the oligosaccharide Glc3–Man9–GlcNAc2 (where Glc is glucose, Man is mannose, and GlcNAc is ''N''-acetylglucosamine). This oligosaccharide is transferred from the dolichol donor onto certain asparagine residues (onto a specific sequence that is "Asn–X–Ser/Thr") of newly forming polypeptide chains. Dolichol is also involved in transfer of the monosaccharides to the forming Glc3–Man9–GlcNAc2–Dolichol carrier. In addition, dolichols can be adducted to proteins as a posttranslational modification, a process in which branched carbohydrate ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dolichyl-phosphatase
The enzyme dolichyl-phosphatase (EC 3.1.3.51) catalyzes the reaction :dolichyl phosphate + H2O \rightleftharpoons dolichol + phosphate This enzyme belongs to the family of hydrolases, to be specific, those acting on phosphoric monoester bonds. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ... is dolichyl-phosphate phosphohydrolase. Other names in common use include dolichol phosphate phosphatase, dolichol phosphatase, dolichol monophosphatase, dolichyl monophosphate phosphatase, dolichyl phosphate phosphatase, polyisoprenyl phosphate phosphatase, polyprenylphosphate phosphatase, and Dol-''P'' phosphatase. This enzyme participates in ''N''-linked-glycan biosynthesis. References * * * EC 3.1.3 Enzymes of unknown structure {{3.1-enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dolichyl-phosphate Beta-D-mannosyltransferase
In enzymology, a dolichyl-phosphate beta-D-mannosyltransferase () is an enzyme that catalyzes the chemical reaction :GDP-mannose + dolichyl phosphate \rightleftharpoons GDP + dolichyl D-mannosyl phosphate Thus, the two substrates of this enzyme are GDP-mannose and dolichyl phosphate, whereas its two products are GDP and dolichyl D-mannosyl phosphate. This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name A systematic name is a name given in a systematic way to one unique group, organism, object or chemical substance, out of a specific population or collection. Systematic names are usually part of a nomenclature. A semisystematic name or semitrivi ... of this enzyme class is GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase. Other names in common use include GDP-Man:DolP mannosyltransferase, dolichyl mannosyl phosphate synthase, dolichyl-phospho-mannose synthase, GDP-mannose:dolichyl-phosphate mannosyltra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DPM1
Dolichol-phosphate mannosyltransferase is an enzyme that in humans is encoded by the ''DPM1'' gene. Function Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose Guanosine diphosphate mannose or GDP-mannose is a nucleotide sugar that is a substrate for glycosyltransferase reactions in metabolism. This compound is a substrate for enzymes called mannosyltransferases. Known as donor of activated mannose in a ... and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. References Further reading * * * * * * * * External links GeneReviews/NCBI/NIH/UW entry on Congenital Disorders of Glycosylation Over ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
