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Senescence
Senescence () or biological aging is the gradual deterioration of Function (biology), functional characteristics in living organisms. Whole organism senescence involves an increase in mortality rate, death rates or a decrease in fecundity with increasing age, at least in the later part of an organism's biological life cycle, life cycle. However, the resulting effects of senescence can be delayed. The 1934 discovery that calorie restriction can Life extension, extend lifespans by 50% in rats, the existence of species having negligible senescence, and the existence of potentially immortal organisms such as members of the genus ''Hydra (genus), Hydra'' have motivated research into Life extension, delaying senescence and thus age-related diseases. Rare human mutations can cause accelerated aging diseases. Environmental Gerontogens, factors may affect aging – for example, overexposure to ultraviolet radiation accelerates skin aging. Different parts of the body may age at different ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hallmarks Of Aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death. The hallmarks of aging are the types of Biochemistry, biochemical changes that occur in all organisms that experience senescence, biological aging and lead to a progressive loss of physiological integrity, impaired function and, eventually, death. They were first listed in a landmark paper in 2013 to conceptualize the essence of Senescence, biological aging and its underlying mechanisms. The following three premises for the interconnected hallmarks have been proposed: * "their age-associated manifestation" * "the acceleration of aging by experimentally accentuating them" * "the opportunity to Life extension, decelerate, stop, or rejuvenation, reverse aging by therapeutic interventions on them" Overview Over time, Negligible senescence, almost all living organisms experience a gradual and irreversible increase in senescence and an associated ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
