Polyclonal Antibodies

	Polyclonal Antibodies Polyclonal antibodies (pAbs) are antibodies that are secreted by different B cell lineages within the body (whereas monoclonal antibodies come from a single cell lineage). They are a collection of immunoglobulin molecules that react against a specific antigen, each identifying a different epitope. Production The general procedure to produce polyclonal antibodies is as follows: # Antigen preparation # Adjuvant selection and preparation # Animal selection # Injection process # Blood serum extraction An antigen/adjuvant conjugate is injected into an animal of choice to initiate an amplified immune response. After a series of injections over a specific length of time, the animal is expected to have created antibodies against the conjugate. Blood is then extracted from the animal and then purified to obtain the antibody of interest. Inoculation is performed on a suitable mammal, such as a mouse, rabbit or goat. Larger mammals are often preferred as the amount of serum that can ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Antibody An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein used by the immune system to identify and neutralize foreign objects such as pathogenic bacteria and Viral disease, viruses. The antibody recognizes a unique molecule of the pathogen, called an antigen. Each tip of the "Y" of an antibody contains a paratope (analogous to a lock) that is specific for one particular epitope (analogous to a key) on an antigen, allowing these two structures to bind together with precision. Using this binding mechanism, an antibody can ''tag'' a microbe or an infected cell for attack by other parts of the immune system, or can neutralize it directly (for example, by blocking a part of a virus that is essential for its invasion). To allow the immune system to recognize millions of different antigens, the antigen-binding sites at both tips of the antibody come in an equally wide variety. In contrast, the remainder of the antibody is relatively constant. It only occurs ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Symphogen Symphogen is a biotechnology company located in Copenhagen, Denmark that develops protein drugs based on recombinant monoclonal antibody mixtures. These drugs are different from the polyclonal antibodies, as each antibody in the mixture is produced from one carefully selected clone. Their three main areas of therapeutic research are immunoglobulin replacement, cancer, and infectious diseases. The company was founded in 2000 and has patents on a drug discovery platform called Symplex and a drug manufacturing platform called Sympress. By 2009, ten drugs were being developed with rozrolimupab (Sym001) being the lead product.Symphogen. Copenhagen 2008 ited 2009 15 April 2009 Available from: http://www.symphogen.com/web/guest. Laboratoires Servier acquired Symphogen in 2020. Partner collaborations Genentech, Inc.: Collaboration pact with Genentech which enables both companies to utilize Symplex technology to help discover new antibodies against three undisclosed infectious disease targ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
picture info	Mineral Oil Mineral oil is any of various colorless, odorless, light mixtures of higher alkanes from a mineral source, particularly a distillate of petroleum, as distinct from usually edible vegetable oils. The name 'mineral oil' by itself is imprecise, having been used for many specific oils over the past few centuries. Other names, similarly imprecise, include 'white oil', 'paraffin oil', ' liquid paraffin' (a highly refined medical grade), (Latin), and 'liquid petroleum'. Most often, mineral oil is a liquid by-product of refining crude oil to make gasoline and other petroleum products. This type of mineral oil is a transparent, colorless oil, composed mainly of alkanes and cycloalkanes, related to petroleum jelly. It has a density of around . Nomenclature Some of the imprecision in the definition of the names used for mineral oil (such as 'white oil') reflects usage by consumers and merchants who did not know, and usually had no need of knowing, the oil's precise chemical makeu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Adjuvant In pharmacology, an adjuvant is a drug or other substance, or a combination of substances, that is used to increase the efficacy or potency of certain drugs. Specifically, the term can refer to: * Adjuvant therapy Adjuvant therapy, also known as adjunct therapy, adjuvant care, or augmentation therapy, is a therapy that is given in addition to the primary or initial therapy to maximize its effectiveness. The surgeries and complex treatment regimens used i ... in cancer management * Analgesic adjuvant in pain management * Immunologic adjuvant in vaccines This is a specialized usage of a word (derived from the Latin verb "adjuvare", ''to help''), which also has a more general meaning as someone or something assisting in any operation or effect. {{sia Adjuvants ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]
	Specol Specol (trade name Stimune) is a water in oil adjuvant composed of defined and purified light mineral oil (Stills. 2005). It has been suggested as an alternative to Freund's adjuvant for hyperactivation of the immune response in rabbits (Leenaars et al. 1994). Specol can be used for antigens of low immunogenicity and can be administered equally effectively by the subcutaneous or intraperitoneal routes. The histological lesions produced are fewer than those produced by using Complete Freund's adjuvant. However, pain Pain is a distressing feeling often caused by intense or damaging stimuli. The International Association for the Study of Pain defines pain as "an unpleasant sensory and emotional experience associated with, or resembling that associated with, ... and distress following administration of these 2 adjuvants seem to be similar (based on limited data). References * * External links Prionics: Stimune Adjuvants Immunology Immune system {{antineoplastic-drug-s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu]