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Pfizer
Pfizer Inc. ( ) is an American Multinational corporation, multinational Pharmaceutical industry, pharmaceutical and biotechnology corporation headquartered at The Spiral (New York City), The Spiral in Manhattan, New York City. Founded in 1849 in New York by German entrepreneurs Charles Pfizer (1824–1906) and Charles F. Erhart (1821–1891), Pfizer is one of the oldest pharmaceutical companies in North America. Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company's largest products by sales are the Pfizer–BioNTech COVID-19 vaccine ($11 billion in 2023 revenues), apixaban ($6 billion in 2023 revenues), a pneumococcal conjugate vaccine ($6 billion in 2023 revenues), palbociclib ($4 billion in 2023 revenues), and tafamidis ($3 billion in 2023 revenues). In 2023, 46% of the company's revenues came from the United States, 6% came from Japan, and 48% came from other countries. Pfizer has been a publi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pfizer–BioNTech COVID-19 Vaccine
The Pfizer–BioNTech COVID-19 vaccine, sold under the brand name Comirnaty, is an MRNA vaccine, mRNA-based COVID-19 vaccine developed by the German biotechnology company BioNTech. For its development, BioNTech collaborated with the American company Pfizer to carry out clinical trials, logistics, and manufacturing. It is authorized for use in humans to provide protection against COVID-19, caused by infection with the Severe acute respiratory syndrome coronavirus 2, SARS-CoV-2 virus. The vaccine is given by intramuscular injection. It is composed of Nucleoside-modified messenger RNA, nucleoside-modified mRNA (modRNA) that encodes a mutated form of the full-length coronavirus spike protein, spike protein of SARS-CoV-2, which is encapsulated in Solid lipid nanoparticle, lipid nanoparticles. Initial guidance recommended a two-dose regimen, given 21 days apart; this interval was subsequently extended to up to 42 days in the United States, and up to four months in Canada. Clinical ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Albert Bourla
Albert Bourla (; born ) is a Greek-American veterinarian and businessman known for serving as the chairman and chief executive officer of the pharmaceutical company Pfizer. He joined the company in 1993 and has held several executive roles across Pfizer's divisions. Prior to becoming chief executive officer, Bourla was chief operating officer. In addition to the boards of Pfizer and the Pfizer Foundation, Bourla is or has been on the boards of the Biotechnology Innovation Organization, Catalyst, the Partnership for New York City, and the Pharmaceutical Research and Manufacturers of America. he is also a member of The Business Council and the Business Roundtable. Bourla reshaped Pfizer to focus on research and development. He is also credited with helping the development of Improvac, which eradicates boar taint, and for refocusing Pfizer's vaccine division to focus on ''Staphylococcus'', ''Clostridioides difficile'' infection, infant diseases, and the Pfizer–BioNTech COVID- ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Charles Pfizer
Karl Christian Friedrich Pfizer (; March 22, 1824October 19, 1906), known as Charles Pfizer, was a German-American businessman and chemist who co-founded the Pfizer pharmaceutical company with his cousin, Charles F. Erhart, in 1849, as Chas. Pfizer & Co. Inc. Life and family He was born Karl Christian Friedrich to Karl Frederick Pfizer and Caroline Klotz. Like his older cousin, future business partner and brother-in-law, Karl Erhart, Pfizer was born in Ludwigsburg, Kingdom of Württemberg (now Germany). During his early years, he worked as an apothecary's apprentice. He emigrated to the United States in October 1848.U.S. Passport Application for Charles Pfizer, May 1899; National Archives and Records Administration (NARA); Washington D.C.; NARA Series: Passport Applications, 1795–1905; Roll #: 525; Volume #: Roll 525 – May 11, 1899 – May 19, 1899 Pfizer married Anna Hausch, in 1859, in his hometown of Ludwigsburg. He met Hausch during one of his trips to Europe to esta ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Palbociclib
Palbociclib, sold under the brand name Ibrance among others, is a medication developed by Pfizer for the treatment of HR-positive and HER2-negative breast cancer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Palbociclib was the first CDK4/6 inhibitor to be approved as a cancer therapy. Mechanism of action It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. In the G1 phase of the cell cycle, mammalian cells must pass a checkpoint, known as the restriction point "R", in order to complete the cell cycle and divide. CDK4 and CDK6 complex with Cyclin D drive the phosphorylation of the retinoblastoma protein, Rb, which allows the cell to pass R and commit to division. Regulation of one or more proteins involved in this checkpoint is lost in many cancers. However, by inhibiting CDK4/6, palbociclib ensures that the cyclin D-CDK4/6 complex cannot aid in phosphorylating Rb. This prevents the cell from passing R and exiting G1, and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pharmaceutical Industry
The pharmaceutical industry is a medical industry that discovers, develops, produces, and markets pharmaceutical goods such as medications and medical devices. Medications are then administered to (or self-administered by) patients for curing or preventing disease or for alleviating symptoms of illness or injury. Pharmaceutical companies may deal in generic drugs, branded drugs, or both, in different contexts. Generic materials are without the involvement of intellectual property, whereas branded materials are protected by chemical patents. The industry's various subdivisions include distinct areas, such as manufacturing biologics and total synthesis. The industry is subject to a variety of laws and regulations that govern the patenting, efficacy testing, safety evaluation, and marketing of these drugs. The global pharmaceutical market produced treatments worth a total of $1,228.45 billion in 2020. The sector showed a compound annual growth rate (CAGR) of 1.8% in 2021, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Apixaban
Apixaban, sold under the brand name Eliquis, is an anticoagulant medication used to treat and prevent blood clots and to prevent stroke in people with nonvalvular atrial fibrillation through directly inhibiting factor Xa. It is used as an alternative to warfarin to prevent blood clots following hip or knee replacement and in those with a history of prior clots and does not require monitoring by blood tests or dietary restrictions. It is taken by mouth. Common side effects include bleeding and nausea. Other side effects may include bleeding around the spine and allergic reactions. Use is not recommended during pregnancy or breastfeeding. Use appears to be relatively safe in those with mild kidney problems. Compared to warfarin it has fewer interactions with other medications. It is a direct factor Xa inhibitor. In 2007, Pfizer and Bristol-Myers Squibb began the development of apixaban as an anticoagulant. Apixaban was approved for medical use in the European Union in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Pneumococcal Conjugate Vaccine
Pneumococcal conjugate vaccine is a pneumococcal vaccine made with the conjugate vaccine method and used to protect infants, young children, and adults against disease caused by the bacterium '' Streptococcus pneumoniae'' (pneumococcus). It contains purified capsular polysaccharide of pneumococcal serotypes conjugated to a carrier protein to improve antibody response compared to the pneumococcal polysaccharide vaccine. The World Health Organization (WHO) recommends the use of the conjugate vaccine in routine immunizations given to children. Vaccine-mediated immunity is "conferred mainly by opsonophagocytic killing of ''S. pneumoniae''." The most common side effects in children are decreased appetite, fever (only very common in children aged six weeks to five years), irritability, reactions at the site of injection (reddening or hardening of the skin, swelling, pain or tenderness), somnolence (sleepiness) and poor quality sleep. In adults and the elderly, the most common sid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tafamidis
Tafamidis, sold under the brand names Vyndaqel and Vyndamax, is a medication used to delay disease progression in adults with certain forms of transthyretin amyloidosis. It can be used to treat both hereditary forms, familial amyloid cardiomyopathy and familial amyloid polyneuropathy, as well as wild-type transthyretin amyloidosis, which formerly was called senile systemic amyloidosis. It works by stabilizing the quaternary structure of the protein transthyretin. In people with transthyretin amyloidosis, transthyretin falls apart and forms clumps called (amyloid) that harm tissues including nerves and the heart. The US Food and Drug Administration considers tafamidis to be a first-in-class medication. Medical use Tafamidis is used to delay nerve damage in adults who have transthyretin amyloidosis with polyneuropathy, or heart disease in adults who have transthyretin amyloidosis with cardiomyopathy. It is taken by mouth. Women should not get pregnant while taking it and sho ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccine
A vaccine is a biological Dosage form, preparation that provides active acquired immunity to a particular infectious disease, infectious or cancer, malignant disease. The safety and effectiveness of vaccines has been widely studied and verified. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or one of its surface proteins. The agent stimulates the body's immune system to recognize the agent as a threat, destroy it, and recognize further and destroy any of the microorganisms associated with that agent that it may encounter in the future. Vaccines can be prophylaxis, prophylactic (to prevent or alleviate the effects of a future infection by a natural or "wild" pathogen), or therapeutic vaccines, therapeutic (to fight a disease that has already occurred, such as cancer vaccine, cancer). Some vaccines offer full sterilizing immunity, in which infection is prevented. T ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Spiral (New York City)
The Spiral, also known as 66 Hudson Boulevard, is a 66-floor, skyscraper with , on 34th Street between Hudson Boulevard and Tenth Avenue in Hudson Yards, Manhattan, New York City. It was developed by Tishman Speyer, constructed by Turner Construction, and opened in 2023. The building got its name as each floor has outdoor gardens that spiral around the facade of the building in a continuous green pathway. It was designed by Bjarke Ingels Group, which also designed the nearby West 57. Space Copenhagen provided interior design services. The building includes a clubhouse and an open-air terrace with panoramic city views on the 66th floor, along with a lounge. The building has an irrigation system provided by Bosch that is designed to save 4.5 million gallons of water per year compared to other systems. History The tower was conceptualized in 2014 as the Hudson Spire, with a roof height and a architectural height. It was marketed as the tallest building in the Western Hemi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
S&P 100
The Standard and Poor's 100, or simply the S&P 100, is a stock market index of United States stocks maintained by Standard & Poor's. The S&P 100 is a subset of the S&P 500 and the S&P 1500, and holds stocks that tend to be the largest and most established companies in the S&P 500. However, the S&P 100 actually includes 101 larger US company stocks due to holding two different share classes of Alphabet Inc. Constituents of the S&P 100 are selected for sector balance and represent nearly 71% of the market capitalization of the S&P 500 and 61% of the market capitalization of the U.S. equity markets as of December 2024. Index options on the S&P 100 are traded with the ticker symbol "OEX". Because of the popularity of these options, investors often refer to the index by its ticker symbol. History In 1983, the CBOE created the first index options, based on its own index, the CBOE 100. In 1993, CBOE created the Chicago Board Options Exchange Market Volatility Index (VIX), which was ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Manhattan
Manhattan ( ) is the most densely populated and geographically smallest of the Boroughs of New York City, five boroughs of New York City. Coextensive with New York County, Manhattan is the County statistics of the United States#Smallest, largest, and average area per state and territory, smallest county by area in the U.S. state of New York (state), New York. Located almost entirely on Manhattan Island near the southern tip of the state, Manhattan constitutes the center of the Northeast megalopolis and the urban core of the New York metropolitan area. Manhattan serves as New York City's Economy of New York City, economic and Government of New York City, administrative center and has been described as the cultural, financial, Media in New York City, media, and show business, entertainment capital of the world. Present-day Manhattan was originally part of Lenape territory. European settlement began with the establishment of a trading post by Dutch colonization of the Americas, D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
