Peripherally Selective Drugs
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Peripherally Selective Drugs
Periphery or peripheral may refer to: Music *Periphery (band), American progressive metal band * ''Periphery'' (album), released in 2010 by Periphery *"Periphery", a song from Fiona Apple's album '' The Idler Wheel...'' Gaming and entertainment *Periphery, a group of political entities in BattleTech, a wargaming franchise *'' The Peripheral'', a 2014 novel by William Gibson ** ''The Peripheral'' (TV series), a streaming series based on Gibson's novel Mathematics *Peripheral, an alternate mathematical term for boundary parallel in manifold theory * Peripheral cycle, a mathematical term in graph theory Computing *Peripheral, a device connected to a computer Political *Periphery countries, the least developed countries in world systems theory *Periphery (France), statistical area designating a commuter belt around an urban unit *Peripheries of Greece or ''administrative regions of Greece'' (Greek: , '), the country's first-level administrative divisions **Peripheral unit ...
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Periphery (band)
Periphery is an American progressive metal band that was formed in Washington, D.C., in 2005. Their musical style has been described as progressive metal, djent, and progressive metalcore. They are considered one of the pioneers of the djent movement within progressive metal. They have also received a Grammy nomination. The band consists of vocalist Spencer Sotelo, guitarists Misha Mansoor, Mark Holcomb, Jake Bowen, and drummer Matt Halpern. Since their Periphery (album), self-titled debut, the band has released an additional six albums: ''Periphery II: This Time It's Personal'', the double album ''Juggernaut: Alpha'' and ''Juggernaut: Omega, Omega'', ''Periphery III: Select Difficulty'', ''Periphery IV: Hail Stan'' and ''Periphery V: Djent Is Not a Genre''. They have also released two EPs: ''Icarus EP'' and Clear (EP), ''Clear''. All Periphery material is self-produced by the members of the band. History Formation and early line-up changes (2005–2009) Periphery was f ...
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Periphery (France)
A periphery, (''Fr: couronne'') is an INSEE (French demographic statistics institution) statistical area designating a commuter belt around an urban unit (''Fr: unité urbaine''). Together these complete the INSEE urban area statistical area. Based on France's '' commune'' system (interlocking administrative subdivisions often comparable to civil parishes, towns or cities A city is a human settlement of a substantial size. The term "city" has different meanings around the world and in some places the settlement can be very small. Even where the term is limited to larger settlements, there is no universally agree ...), a commune is considered part of a couronne when # it is not densely constructed enough or is too isolated to be part of any '' unité urbaine'' (or "'' pôle urbain''" if it is the core of the agglomeration), and # at least 40% of its population commutes to workplaces in a '' unité urbaine'' or '' pôle urbain'', or to another commune connected to a '' unité urb ...
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Peripheral Vision
Peripheral vision, or ''indirect vision'', is vision as it occurs outside the point of fixation, i.e. away from the center of gaze or, when viewed at large angles, in (or out of) the "corner of one's eye". The vast majority of the area in the visual field is included in the notion of peripheral vision. "Far peripheral" vision refers to the area at the edges of the visual field, "mid-peripheral" vision refers to medium eccentricities, and "near-peripheral", sometimes referred to as "para-central" vision, exists adjacent to the center of gaze. Boundaries Inner boundaries The inner boundaries of peripheral vision can be defined in any of several ways depending on the context. In everyday language the term "peripheral vision" is often used to refer to what in technical usage would be called "far peripheral vision." This is vision outside of the range of stereoscopic vision. It can be conceived as bounded at the center by a circle 60° in radius or 120° in diameter, centered aro ...
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Peripheral Nervous System
The peripheral nervous system (PNS) is one of two components that make up the nervous system of Bilateria, bilateral animals, with the other part being the central nervous system (CNS). The PNS consists of nerves and ganglia, which lie outside the brain and the spinal cord. The main function of the PNS is to connect the CNS to the Limb (anatomy), limbs and Organ (anatomy), organs, essentially serving as a relay between the brain and spinal cord and the rest of the body. Unlike the CNS, the PNS is not protected by the vertebral column and skull, or by the blood–brain barrier, which leaves it exposed to toxins. The peripheral nervous system can be divided into a somatic nervous system, somatic division and an autonomic nervous system, autonomic division. Each of these can further be differentiated into a sensory and a motor sector. In the somatic nervous system, the cranial nerves are part of the PNS with the exceptions of the olfactory nerve and epithelia and the optic nerve (c ...
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Peripherally Selective Drug
Peripherally selective drugs have their primary mechanism of action outside of the central nervous system (CNS), usually because they are excluded from the CNS by the blood–brain barrier. By being excluded from the CNS, drugs may act on the rest of the body without producing side-effects related to their effects on the brain or spinal cord. For example, most opioids cause sedation when given at a sufficiently high dose, but peripherally selective opioids can act on the rest of the body without entering the brain and are less likely to cause sedation. These peripherally selective opioids can be used as antidiarrheals, for instance loperamide (Imodium). Mechanisms of peripheral selectivity include physicochemical hydrophilicity and large molecular size, which prevent drug permeation through the lipid bilayer cell membranes of the blood–brain barrier, and efflux out of the brain by blood–brain barrier transporters such as P-glycoprotein among many others. Transport out of the b ...
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Human Body
The human body is the entire structure of a Human, human being. It is composed of many different types of Cell (biology), cells that together create Tissue (biology), tissues and subsequently Organ (biology), organs and then Organ system, organ systems. The external human body consists of a human head, head, hair, neck, torso (which includes the thorax and abdomen), Sex organ, genitals, arms, Hand, hands, human leg, legs, and Foot, feet. The internal human body includes organs, Human tooth, teeth, bones, muscle, tendons, ligaments, blood vessels and blood, lymphatic vessels and lymph. The study of the human body includes anatomy, physiology, histology and embryology. The body Anatomical variation, varies anatomically in known ways. Physiology focuses on the systems and organs of the human body and their functions. Many systems and mechanisms interact in order to maintain homeostasis, with safe levels of substances such as sugar, iron, and oxygen in the blood. The body is st ...
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Peripheral Units Of Greece
The 74 regional units of Greece (, ; singular , ) are the country's third-level administrative units (counting decentralized administrations as first-level). They are subdivisions of the country's 13 regions, and are further divided into municipalities. They were introduced as part of the Kallikratis administrative reform on 1 January 2011 and are comparable in area and, on the mainland, coterminous with the "pre-Kallikratis" prefectures of Greece Until the Kallikratis reform in 2010, the prefectures () were the second-level administrative regions of Greece. They are now defunct, and have been approximately replaced by regional units. They are called departments in ISO 3166-2:GR and b .... List References {{Articles on second-level administrative divisions of European countries Regional units Greece transport-related lists Subdivisions of Greece ...
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Peripheries Of Greece
The regions of Greece () are the country's thirteen second-level administrative entities, counting decentralized administrations of Greece as first-level. Regions are divided into regional units, known as prefectures until 2011. History The current regions were established in July 1986 (the presidential decree officially establishing them was signed in 1987), by decision of the interior minister, Menios Koutsogiorgas, as second-level administrative entities, complementing the prefectures (Law 1622/1986). Ν.1622/86 "Τοπική Αυτοδιοίκηση - Περιφερειακή Ανάπτυξη - Δημοκρατικός Προγραμματισμός", (ΦΕΚ 92/τ.Α΄/14-7-1986) Before 1986, there was a traditional division into broad historical–geographical regions (γεωγραφικά διαμερίσματα), which, however, was often arbitrary; not all of the pre-1986 traditional historical-geographic regions had official administrative bodies. Although the p ...
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Periphery Countries
In world-systems theory, periphery countries are those that are less developed than the semi-periphery and core countries. These countries usually receive a disproportionately small share of global wealth. They have weak state institutions and are dependent on—and, according to some, exploited by— more developed countries. These countries are usually behind because of obstacles such as lack of technology, unstable government, and poor education and health systems. In some instances, the exploitation of periphery countries' agriculture, cheap labor, and natural resources aid core countries in remaining dominant. This is best described by dependency theory,Thomas Shannon. An Introduction to the World-System Perspective. 1996. which is one theory on how globalization can affect the world and the countries in it. It is, however, possible for periphery countries to rise out of their status and move into semi-periphery or core status. This can be done by doing things such a ...
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Periphery (album)
''Periphery'' is the debut studio album by American progressive metal band Periphery. It was released on April 20, 2010 through Sumerian Records, and was produced by the band themselves and Matt Murphy. Many songs on the tracklist had been written long before the release date—with some written by original lead vocalist Casey Sabol—but due to membership changes, the album was postponed on several occasions. Former vocalist Chris Barretto had nearly finished recording the album before he and the band parted ways months before its release. Rather than release the songs with Barretto's vocals, the band decided to rerecord Barretto's songs with Spencer Sotelo; however, Sotelo only re-worked a few of the melodies when recording vocals, versus writing completely new lyrics. As a result, Sabol's and Barretto's lyrics and vocal melodies and harmonies are still featured on the record. The album was re-released on February 6, 2012 as a 'Special Edition' including instrumentals, along wi ...
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Peripheral
A peripheral device, or simply peripheral, is an auxiliary hardware device that a computer uses to transfer information externally. A peripheral is a hardware component that is accessible to and controlled by a computer but is not a core component of the computer. A peripheral can be categorized based on the direction in which information flows relative to the computer: * The computer receives data from an '' input device''; examples: mouse, keyboard, scanner, game controller, microphone and webcam * The computer sends data to an '' output device''; examples: monitor, printer, headphones, and speakers * The computer sends and receives data via an ''input/output device''; examples: storage device (such as disk drive, solid-state drive, USB flash drive, memory card and tape drive), modem, router, gateway and network adapter Many modern electronic devices, such as Internet-enabled digital watches, video game consoles, smartphones, and tablet computers, have in ...
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Peripheral Cycle
In graph theory, a peripheral cycle (or peripheral circuit) in an undirected graph is, intuitively, a cycle that does not separate any part of the graph from any other part. Peripheral cycles (or, as they were initially called, peripheral polygons, because Tutte called cycles "polygons") were first studied by , and play important roles in the characterization of planar graphs and in generating the cycle spaces of nonplanar graphs. Definitions A peripheral cycle C in a graph G can be defined formally in one of several equivalent ways: *C is peripheral if it is a simple cycle in a connected graph with the property that, for every two edges e_1 and e_2 in G\setminus C, there exists a path in G that starts with e_1, ends with e_2, and has no interior vertices belonging to C.. *If C is any subgraph of G, a ''bridge'' of C is a minimal subgraph B of G that is edge-disjoint from C and that has the property that all of its points of attachments (vertices adjacent to edges in both B an ...
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