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Farnesyl Pyrophosphate Synthase Inhibitors
Farnesol is a natural 15-carbon organic compound which is an acyclic sesquiterpene alcohol. Under standard conditions, it is a colorless liquid. It is hydrophobic, and thus insoluble in water, but miscible with oils. As the pyrophosphate ester, farnesol is a precursor to many terpenes and terpenoids. Uses Farnesol is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam, and tolu. It is used in perfumery to emphasize the odors of sweet, floral perfumes. It enhances perfume scent by acting as a co-solvent that regulates the volatility of the odorants. It is especially used in lilac and peony perfumes. Farnesol and its ester derivatives are important precursors for a variety of other compounds used as fragrances and vitamins. Cosmetics Farnesol is used as a deodorant in cosmetic products. Farnesol is subject to restrictions on its use in perfumery, because some people may become sensitised to it. Natural source and synt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Organic Compound
Some chemical authorities define an organic compound as a chemical compound that contains a carbon–hydrogen or carbon–carbon bond; others consider an organic compound to be any chemical compound that contains carbon. For example, carbon-containing compounds such as alkanes (e.g. methane ) and its derivatives are universally considered organic, but many others are sometimes considered inorganic, such as certain compounds of carbon with nitrogen and oxygen (e.g. cyanide ion , hydrogen cyanide , chloroformic acid , carbon dioxide , and carbonate ion ). Due to carbon's ability to catenate (form chains with other carbon atoms), millions of organic compounds are known. The study of the properties, reactions, and syntheses of organic compounds comprise the discipline known as organic chemistry. For historical reasons, a few classes of carbon-containing compounds (e.g., carbonate salts and cyanide salts), along with a few other exceptions (e.g., carbon dioxide, and even ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Steroid
A steroid is an organic compound with four fused compound, fused rings (designated A, B, C, and D) arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and as signal transduction, signaling molecules. Examples include the lipid cholesterol, sex hormones estradiol and testosterone, anabolic steroids, and the anti-inflammatory corticosteroid drug dexamethasone. Hundreds of steroids are found in Fungus, fungi, plants, and animals. All steroids are manufactured in cells from a sterols, sterol: Cholesterol, cholesterol (animals), lanosterol (opisthokonts), or cycloartenol (plants). All three of these molecules are produced via Cyclic compound, cyclization of the triterpene squalene. Structure The steroid nucleus (parent structure, core structure) is called gonane (cyclopentanoperhydrophenanthrene). It is typically composed of seventeen carbon atoms, bonded in fou ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Farnese Gardens
The Farnese Gardens (), or "Gardens of Farnese upon the Palatine", are a garden in Rome, central Italy, created in 1550 on the northern portion of Palatine Hill, by Cardinal Alessandro Farnese. They were the first private botanical gardens in Europe; the first botanical gardens of any kind in Europe were started by Italian universities in the mid-16th century, only a short time before. Alessandro Farnese was appointed Cardinal Deacon of the Roman Catholic Church in 1534 at the age of 14, by Paul III, his grandfather, who had been elected to the papacy two months previously. He is remembered for being an antiquarian who assembled the greatest collection of Roman sculpture assembled in private hands since antiquity, the famous Farnese Collection. In 1550, when Farnese acquired a northern portion of Palatine hill (historically the oldest of Rome's seven hills) he had ruins from a Roman palace of Tiberius at the northwest end of the hill top filled in, and converted to a summer h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
House Of Farnese
The House of Farnese (, also , ) was an influential family in Renaissance Italy. The titles of Duke of Parma and Piacenza, Duke of Latera and Duke of Castro were held by various members of the family. Its most important members included Pope Paul III, Alessandro Farnese (a cardinal), Alexander Farnese, Duke of Parma and Piacenza (a military commander and Governor of the Spanish Netherlands), and Elisabeth Farnese, who became Queen of Spain and whose legacy was brought to her Bourbon descendants. A number of important architectural works and antiquities are associated with the Farnese family, either through construction or acquisition. Buildings include the Palazzo Farnese in Rome and the Villa Farnese at Caprarola, and ancient artifacts include the Farnese Marbles. History Origins The family could trace its origins back to around AD 984 and took its name from one of its oldest feudal possessions - ''Castrum Farneti''. There has been some debate as to the origi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Odoardo Farnese (cardinal)
Odoardo Farnese (6 December 1573 – 21 February 1626) was an Italian nobleman, the second son of Alessandro Farnese, Duke of Parma and Maria of Portugal (1538-1577), Maria of Portugal, known for his patronage of the arts. He became a Cardinal (Catholicism), Cardinal of the Catholic Church in 1591, and briefly acted as regent of the Duchy of Parma and Piacenza for his nephew Odoardo Farnese, Duke of Parma, Odoardo from 1622 to 1626. Cardinal Odoardo is probably best known today for commissioning the Bolognese artist Annibale Carracci to fresco the Camerino in the Palazzo Farnese in Rome. Carracci undertook this from 1595 to 1597, just prior to starting his decoration of the more famous and elaborate Farnese Gallery in the same palace. The Camerino The Camerino was Farnese's private study. The subject of the central scene in the ceiling is ''Hercules at the crossroads, The Choice of Hercules''. The scene is surrounded by a painted frame, an example of ''quadro riportato'', which g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vachellia Farnesiana
''Vachellia farnesiana'', also known as ''Acacia farnesiana'', and previously ''Mimosa farnesiana'', commonly known as sweet acacia, huisache, casha tree, or needle bush, is a species of shrub or small tree in the legume family, Fabaceae. Its flowers are used in the perfume industry. Description The plant is deciduous over part of its range, but evergreen in most locales. Growing from multiple trunks, it reaches a height of . The bark is whitish gray. The base of each leaf is accompanied by a pair of thorns on the branch. The dark brown fruit is a seed pod. Taxonomy Taxonomic history It was first described by Europeans under the name ''Acacia Indica Farnesiana'' in 1625 by Tobias Aldini from plants grown in Rome in the Farnese Gardens from seed collected in Santo Domingo, in what is now the Dominican Republic, which germinated in 1611. Aldini included an illustration of the plant, which he contrasted with an illustration of the first known ''Acacia''; ''Acacia nilotica''. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Linalool
Linalool () refers to two enantiomers of a naturally occurring terpene alcohol found in many flowers and spice plants. Together with geraniol, nerol, and citronellol, linalool is one of the rose alcohols. Linalool has multiple commercial applications, the majority of which are based on its pleasant scent (floral, with a touch of spiciness). A colorless oil, linalool is classified as an acyclic monoterpenoid. In plants, it is a metabolite, a volatile oil component, an antimicrobial agent, and an aroma compound. Linalool has uses in manufacturing of soaps, fragrances, food additives as flavors, household products, and insecticides. Esters of linalool are referred to as linalyl, e.g. linalyl pyrophosphate, an isomer of geranyl pyrophosphate. The word ''linalool'' is based on '' linaloe'' (a type of wood) and the suffix '. In food manufacturing, it may be called ''coriandrol''. Occurrence Both enantiomeric forms are found in nature: (''S'')-linalool is found, for exam ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Filamentation
Filamentation is the anomalous growth of certain bacteria, such as ''Escherichia coli'', in which cells continue to elongate but do not divide (no septa formation). The cells that result from elongation without division have multiple chromosomal copies. In the absence of antibiotics or other stressors, filamentation occurs at a low frequency in bacterial populations (4–8% short filaments and 0–5% long filaments in 1- to 8-hour cultures). The increased cell length can protect bacteria from protozoan predation and neutrophil phagocytosis by making ingestion of cells more difficult. Filamentation is also thought to protect bacteria from antibiotics, and is associated with other aspects of bacterial virulence such as biofilm formation. The number and length of filaments within a bacterial population increases when the bacteria are exposed to different physical, chemical and biological agents (e.g. UV light, DNA synthesis-inhibiting antibiotics, bacteriophages). This is terme ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quorum Sensing
In biology, quorum sensing or quorum signaling (QS) is the process of cell-to-cell communication that allows bacteria to detect and respond to cell population density by gene regulation, typically as a means of acclimating to environmental disadvantages. Quorum sensing is a type of cellular signaling, and can be more specifically considered a type of paracrine signaling. However, it also contains traits of autocrine signaling: a cell produces both an autoinducer molecule and the receptor for the autoinducer. As one example, quorum sensing enables bacteria to restrict the expression of specific genes to the high cell densities at which the resulting phenotypes will be most beneficial, especially for phenotypes that would be ineffective at low cell densities and therefore too energetically costly to express. Many species of bacteria use quorum sensing to coordinate gene expression according to the density of their local population. In a similar fashion, some social insects use q ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Candida Albicans
''Candida albicans'' is an opportunistic pathogenic yeast that is a common member of the human gut flora. It can also survive outside the human body. It is detected in the gastrointestinal tract and mouth in 40–60% of healthy adults. It is usually a commensal organism, but it can become pathogenic in immunocompromised individuals under a variety of conditions. It is one of the few species of the genus '' Candida'' that cause the human infection candidiasis, which results from an overgrowth of the fungus. Candidiasis is, for example, often observed in HIV-infected patients. ''C. albicans'' is the most common fungal species isolated from biofilms either formed on (permanent) implanted medical devices or on human tissue. ''C. albicans'', ''C. tropicalis'', ''C. parapsilosis'', and ''C. glabrata'' are together responsible for 50–90% of all cases of candidiasis in humans. A mortality rate of 40% has been reported for patients with systemic candidiasis due to ''C. albicans''. B ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Farnesyl Pyrophosphate Skeletal
Farnesol is a natural 15-carbon organic compound which is an acyclic sesquiterpene alcohol. Under standard conditions, it is a colorless liquid. It is hydrophobic, and thus insoluble in water, but miscible with oils. As the pyrophosphate ester, farnesol is a precursor to many terpenes and terpenoids. Uses Farnesol is present in many essential oils such as citronella, neroli, cyclamen, lemon grass, tuberose, rose, musk, balsam, and tolu. It is used in perfumery to emphasize the odors of sweet, floral perfumes. It enhances perfume scent by acting as a co-solvent that regulates the volatility of the odorants. It is especially used in lilac and peony perfumes. Farnesol and its ester derivatives are important precursors for a variety of other compounds used as fragrances and vitamins. Cosmetics Farnesol is used as a deodorant in cosmetic products. Farnesol is subject to restrictions on its use in perfumery, because some people may become sensitised to it. Natural source and synt ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
