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CoviVac (Russia COVID‑19 Vaccine)
CoviVac () is an inactivated virus-based COVID-19 vaccine developed by the , which is an institute of the Russian Academy of Sciences. It was approved for use in Russia in February 2021, being the third COVID-19 vaccine to get approval in Russia. It obtained a permission for phase III clinical trial on 2 June 2021. Medical use The CoviVac shot is given in two doses, 14 days apart. It is transported and stored at normal refrigerated temperatures, of 2 to 8 degrees Celsius (35.6 to 46.4 Fahrenheit). Efficacy has not yet been established in a phase III clinical trial. Chemistry One dose of 0.5 ml is composed only of 3 μg or more of SARS-CoV-2 strain AYDAR-1 antigen inactivated by beta-propiolactone and the following excipients: * 0.3–0.5 mg of aluminum hydroxide (adjuvant) * 0.5 ml or less of phosphate buffer solution composed of disodium phosphate dihydrate, sodium dihydrogen phosphate dihydrate, sodium chloride, and water for injection Manufacturing As an inac ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional name 2019 novel coronavirus (2019-nCoV), and has also been called human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization designated the outbreak a public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is Contagious disease, contagious in humans. SARS‑CoV‑2 is a strain of the species ''Betacoronavirus pandemicum'' (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of Zoonosis, z ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Excipient
An excipient is a substance formulated alongside the active ingredient of a medication. They may be used to enhance the active ingredient’s therapeutic properties; to facilitate drug absorption; to reduce viscosity; to enhance solubility; to improve long-term stabilization (preventing denaturation and aggregation during the expected shelf life); or to add bulk to solid formulations that have small amounts of potent active ingredients (in that context, they are often referred to as "bulking agents", "fillers", or "diluents"). During the manufacturing process, excipients can improve the handling of active substances and facilitate powder flow. The choice of excipients depends on factors such as the intended route of administration, the dosage form, and compatibility with the active ingredient. Virtually all marketed drugs contain excipients, and final drug formulations commonly contain more excipient than active ingredient. Pharmaceutical regulations and standards mandate the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
List Of Russian Drugs
This page is a list of Russian drugs, or drugs that were developed in Russia, the former Soviet Union, and/or post-Soviet countries. Many Russian drugs are indicated for enhancing physical, mental, and/or cognitive performance, including drugs described as nootropics or cognitive enhancers, drugs combatting fatigue, so-called adaptogens or actoprotectors, and others. There have been concerns about Russian drugs in the Western world owing to allegedly lower standards of medical evidence in Russia compared to the West, for instance in the case of the Russian COVID vaccine Sputnik V. Some Russian drugs have been attempted to be repurposed and developed by pharmaceutical companies for use in the West, such as phenylpiracetam (fonturacetam), (''R'')-phenylpiracetam (MRZ-9547), Noopept (omberacetam), and armesocarb (the active enantiomer of mesocarb). List of Russian drugs * Aceclidine (Glaucostat, Glaunorm, Glaudin) – parasympathomimetic miotic * Acetomepregenol ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vladimir Putin
Vladimir Vladimirovich Putin (born 7 October 1952) is a Russian politician and former intelligence officer who has served as President of Russia since 2012, having previously served from 2000 to 2008. Putin also served as Prime Minister of Russia from 1999 to 2000 and again from 2008 to 2012. He is the longest-serving Russian president since the independence of Russia from the Soviet Union. Putin worked as a KGB foreign intelligence officer for 16 years, rising to the rank of Lieutenant colonel (Eastern Europe), lieutenant colonel. He resigned in 1991 to begin a political career in Saint Petersburg. In 1996, he moved to Moscow to join the administration of President Boris Yeltsin. He briefly served as the director of the Federal Security Service (FSB) and then as Secretary of the Security Council of Russia, secretary of the Security Council of Russia before Putin's rise to power, being appointed prime minister in August 1999. Following Yeltsin's resignation, Putin became Actin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vero Cell
Vero cells are a lineage of cells used in cell cultures. The 'Vero' lineage was isolated from kidney epithelial cells extracted from an African green monkey ('' Chlorocebus'' sp.; formerly called ''Cercopithecus aethiops'', this group of monkeys has been split into several different species). The lineage was developed on 27 March 1962 by Yasumura and Kawakita at the Chiba University in Chiba, Japan. The original cell line was named '' Vero'' after an abbreviation of , which means 'green kidney' in Esperanto, while itself means 'truth' in Esperanto. Characteristics The Vero cell lineage is continuous and aneuploid, meaning that it has an abnormal number of chromosomes. A continuous cell lineage can be replicated through many cycles of division and not become senescent. Vero cells are interferon-deficient; unlike normal mammalian cells, they do not secrete interferon alpha or beta when infected by viruses. However, they still have the Interferon-alpha/beta receptor, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Severe Acute Respiratory Syndrome Coronavirus 2
Severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) is a strain of coronavirus that causes COVID-19, the respiratory illness responsible for the COVID-19 pandemic. The virus previously had the Novel coronavirus, provisional name 2019 novel coronavirus (2019-nCoV), and has also been called human coronavirus 2019 (HCoV-19 or hCoV-19). First identified in the city of Wuhan, Hubei, China, the World Health Organization designated the outbreak a public health emergency of international concern from January 30, 2020, to May 5, 2023. SARS‑CoV‑2 is a positive-sense single-stranded RNA virus that is Contagious disease, contagious in humans. SARS‑CoV‑2 is a strain of the species ''Betacoronavirus pandemicum'' (SARSr-CoV), as is SARS-CoV-1, the virus that caused the 2002–2004 SARS outbreak. There are animal-borne coronavirus strains more closely related to SARS-CoV-2, the most closely known relative being the BANAL-52 bat coronavirus. SARS-CoV-2 is of Zoonosis, z ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Polio Vaccine
Polio vaccines are vaccines used to prevent poliomyelitis (polio). Two types are used: an inactivated vaccine, inactivated poliovirus given by injection (IPV) and a attenuated vaccine, weakened poliovirus given by mouth (OPV). The World Health Organization (WHO) recommends all children be fully vaccinated against polio. The two vaccines have eliminated polio from most of the world, and reduced the number of cases reported each year from an estimated 350,000 in 1988 to 33 in 2018. The inactivated polio vaccines are very safe. Mild redness or pain may occur at the site of injection. Oral polio vaccines cause about three cases of vaccine-associated paralytic poliomyelitis per million doses given. This compares with 5,000 cases per million who are paralysed following a polio infection. Both types of vaccine are generally safe to give during pregnancy and in those who have HIV/AIDS, but are otherwise well. However, the emergence of circulating vaccine-derived poliovirus (cVDPV), a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Inactivated Vaccine
An inactivated vaccine (or killed vaccine) is a type of vaccine that contains pathogens (such as virus or bacteria) that have been killed or rendered inactive, so they cannot replicate or cause disease. In contrast, live vaccines use pathogens that are still alive (but are almost always attenuated, that is, weakened). Pathogens for inactivated vaccines are grown under controlled conditions and are killed as a means to reduce infectivity and thus prevent infection from the vaccine. Inactivated vaccines were first developed in the late 1800s and early 1900s for cholera, plague, and typhoid. In 1897, Japanese scientists developed an inactivated vaccine for the bubonic plague. In the 1950s, Jonas Salk created an inactivated vaccine for the poliovirus, creating the first vaccine that was both safe and effective against polio. Today, inactivated vaccines exist for many pathogens, including influenza, polio (IPV), rabies, hepatitis A, CoronaVac, Covaxin and pertussis. Because ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Water For Injection
Water for injection is water of extra high quality without significant contamination. A sterile version is used for making solutions that will be given by injection. Before such use other substances generally must be added to make the solution isotonic. Isotonic solutions containing water for injection can be given by injection into a vein, muscle, or under the skin. A non-sterile version may be used in manufacturing with sterilization occurring later in the production process. Side effects and mechanisms The primary use of sterile water for injection is as an ingredient for dilution of other medications ( aseptic preparation of parenteral solutions). If it is given by injection into a vein without making it approximately isotonic, breakdown of red blood cells may occur. This can then result in kidney problems. Excessive amount may also result in fluid overload. Water for injection is generally made by distillation or reverse osmosis. It should contain less than a mg of el ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Chloride
Sodium chloride , commonly known as Salt#Edible salt, edible salt, is an ionic compound with the chemical formula NaCl, representing a 1:1 ratio of sodium and chloride ions. It is transparent or translucent, brittle, hygroscopic, and occurs as the mineral halite. In its edible form, it is commonly used as a condiment and curing (food preservation), food preservative. Large quantities of sodium chloride are used in many industrial processes, and it is a major source of sodium and chlorine compounds used as feedstocks for further Chemical synthesis, chemical syntheses. Another major application of sodium chloride is deicing of roadways in sub-freezing weather. Uses In addition to the many familiar domestic uses of salt, more dominant applications of the approximately 250 million tonnes per year production (2008 data) include chemicals and de-icing.Westphal, Gisbert ''et al.'' (2002) "Sodium Chloride" in Ullmann's Encyclopedia of Industrial Chemistry, Wiley-VCH, Weinheim . Chem ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sodium Dihydrogen Phosphate
Monosodium phosphate (MSP), also known as monobasic sodium phosphate and sodium dihydrogen phosphate, is an inorganic compound with the chemical formula . It is a sodium salt of phosphoric acid. It consists of sodium cations () and dihydrogen phosphate anions (). One of many sodium phosphates, it is a common industrial chemical. The salt exists in an anhydrous form, as well as monohydrate and dihydrate ( and respectively). Production and reactions The salt is obtained by partial neutralization of phosphoric acid. The p''K''a of monosodium phosphate is 6.8-7.2 (depending on the physicochemical characteristics during p''K''a determination). Heating this salt above 169 °C gives disodium pyrophosphate: : When heated at 550 °C, anhydrous trisodium trimetaphosphate is formed: : Uses Phosphates are often used in foods and in water treatment. The pH of such formulations is adjusted by mixtures of various sodium phosphates, such as this salt. It is added in animal fee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disodium Phosphate
Disodium phosphate (DSP), or disodium hydrogen phosphate, or sodium phosphate dibasic, is an inorganic compound with the chemical formula . It is one of several sodium phosphates. The salt is known in anhydrous form as well as hydrates , where ''n'' is 2, 7, 8, and 12. All are water-soluble white powders. The anhydrous salt is hygroscopic. The pH of disodium hydrogen phosphate water solution is between 8.0 and 11.0, meaning it is moderately basic: : Production and reactions It can be generated by neutralization of phosphoric acid with sodium hydroxide: : Industrially It is prepared in a two-step process by treating dicalcium phosphate with sodium bisulfate, which precipitates calcium sulfate:Klaus Schrödter, Gerhard Bettermann, Thomas Staffel, Friedrich Wahl, Thomas Klein, Thomas Hofmann "Phosphoric Acid and Phosphates" in ''Ullmann’s Encyclopedia of Industrial Chemistry'' 2008, Wiley-VCH, Weinheim. : In the second step, the resulting solution of monosodium phosphate i ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
