Cordyceps Sinclairii
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Cordyceps Sinclairii
''Isaria sinclairii'' is a species of entomopathogenic fungus mostly infecting the underground nymphs of cicadas. It produces myriocin, from which the synthetic drug fingolimod, a treatment for multiple sclerosis, was developed. Taxonomy ''Isaria sinclairii'' is the name of the anamorph; the teleomorph is ''Cordyceps sinclairii'', Cordycipitaceae. The species was first described in 1855 by Miles Joseph Berkeley from specimens collected in the garden of Archdeacon William Williams at Tūranga, Poverty Bay. It was moved to the genus '' Isaria'' in 1923 by Curtis Gates Lloyd. Ecology ''Isaria sinclairii'' is a fungus which attacks insects, including cicada larvae. The larvae typically die just beneath the soil surface, and the fungus produces white tufts which grow up from the soil and release powdery white spores. ''I. sinclairii'' is found from Asia (particularly China, Japan, and Korea) through to New Zealand. In New Zealand it attacks cicadas of the genera '' Amphipsalta'' ...
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Miles Joseph Berkeley
Miles Joseph Berkeley (1 April 1803 – 30 July 1889) was an English cryptogamist and clergyman, and one of the founders of the science of plant pathology. Life Berkeley was born at Biggin Hall, Benefield, Northamptonshire, and educated at Rugby School and Christ's College, Cambridge. Taking holy orders, he became incumbent of Apethorpe in 1837, and vicar of Sibbertoft, near Market Harborough, in 1868. He acquired an enthusiastic love of cryptogamic botany (lichens) in his early years, and soon was recognized as the leading British authority on fungi and plant pathology. Christ's College made him an honorary fellow in 1883. He was well known as a systematist in mycology with some 6000 species of fungi being credited to him, but his ''Introduction to Cryptogamic Botany'', published in 1857, and his papers on Vegetable Pathology in the ''Gardener's Chronicle'' in 1854 and onwards, show that he had a broad grasp of the whole domain of physiology and morphology as understood ...
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Genus
Genus (; : genera ) is a taxonomic rank above species and below family (taxonomy), family as used in the biological classification of extant taxon, living and fossil organisms as well as Virus classification#ICTV classification, viruses. In binomial nomenclature, the genus name forms the first part of the binomial species name for each species within the genus. :E.g. ''Panthera leo'' (lion) and ''Panthera onca'' (jaguar) are two species within the genus ''Panthera''. ''Panthera'' is a genus within the family Felidae. The composition of a genus is determined by taxonomy (biology), taxonomists. The standards for genus classification are not strictly codified, so different authorities often produce different classifications for genera. There are some general practices used, however, including the idea that a newly defined genus should fulfill these three criteria to be descriptively useful: # monophyly – all descendants of an ancestral taxon are grouped together (i.e. Phylogeneti ...
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Radio New Zealand
Radio New Zealand (), commonly known as RNZ or Radio NZ, is a New Zealand public service broadcaster and Crown entity. Established under the Radio New Zealand Act 1995, it operates news and current affairs station, RNZ National, and a classical music and jazz station, RNZ Concert, with full government funding from NZ On Air. Since 2014, the organisation's focus has been to transform from a radio broadcaster to a multimedia outlet, increasing its production of digital content in audio, video, and written forms, utilising rnz.co.nz and the RNZ app. The organisation plays a central role in New Zealand public broadcasting. The New Zealand Parliament fully funds its AM network, used in part for the broadcast of parliamentary proceedings. RNZ has a statutory role under the Civil Defence Emergency Management Act 2002 to act as a "lifeline utility" in emergencies. It is also responsible for an international service, RNZ Pacific, which broadcasts to the South Pacific in both ...
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Food And Drug Administration
The United States Food and Drug Administration (FDA or US FDA) is a List of United States federal agencies, federal agency of the United States Department of Health and Human Services, Department of Health and Human Services. The FDA is responsible for protecting and promoting public health through the control and supervision of food safety, tobacco products, caffeine products, dietary supplements, Prescription drug, prescription and Over-the-counter drug, over-the-counter pharmaceutical drugs (medications), vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices (ERED), cosmetics, Animal feed, animal foods & feed and Veterinary medicine, veterinary products. The FDA's primary focus is enforcement of the Federal Food, Drug, and Cosmetic Act (FD&C). However, the agency also enforces other laws, notably Section 361 of the Public Health Service Act as well as associated regulations. Much of this regulatory-enforcement work is ...
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The Journal Of Antibiotics
''The Journal of Antibiotics'' is a peer-reviewed medical journal published by the Nature Publishing Group for the Japan Antibiotics Research Association. The journal seeks to endorse studies on antibiotics and associated types of biologically-active substances. In June 2020, the journal published a pioneer systematic review on ivermectin and COVID-19 by Fatemeh Heiday and Reza Gharebaghi which has become highly cited. Abstracting and indexing The journal is abstracted and indexed for example in: According to the ''Journal Citation Reports'', the journal has a 2022 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.3. References External links * Microbiology journals Nature Research academic journals Monthly journals Academic journals establish ...
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Immunosuppression
Immunosuppression is a reduction of the activation or efficacy of the immune system. Some portions of the immune system itself have immunosuppressive effects on other parts of the immune system, and immunosuppression may occur as an adverse reaction to treatment of other conditions. In general, deliberately induced immunosuppression is performed to prevent the body from rejecting an organ transplant. Additionally, it is used for treating graft-versus-host disease after a bone marrow transplant, or for the treatment of auto-immune diseases such as systemic lupus erythematosus, rheumatoid arthritis, Sjögren's syndrome, or Crohn's disease. This is typically done using medications, but may involve surgery (splenectomy), plasmapheresis, or radiation. A person who is undergoing immunosuppression, or whose immune system is weak for some other reasons (such as chemotherapy or HIV), is said to be ''immunocompromised''. Deliberately induced Administration of immunosuppressive medi ...
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Sphingolipid
Sphingolipids are a class of lipids containing a backbone of sphingoid bases, which are a set of aliphatic amino alcohols that includes sphingosine. They were discovered in brain extracts in the 1870s and were named after the mythological sphinx because of their enigmatic nature. These compounds play important roles in signal transduction and cell recognition. Sphingolipidoses, or disorders of sphingolipid metabolism, have particular impact on neural tissue. A sphingolipid with a terminal hydroxyl group is a ceramide. Other common groups bonded to the terminal oxygen atom include phosphocholine, yielding a sphingomyelin, and various sugar monomers or dimers, yielding cerebrosides and globosides, respectively. Cerebrosides and globosides are collectively known as glycosphingolipids. Structure The long-chain bases, sometimes simply known as sphingoid bases, are the first non-transient products of '' de novo'' sphingolipid synthesis in both yeast and mammals. These co ...
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Eternal Youth
Eternal youth is the concept of human physical immortality free of ageing. The youth referred to is usually meant to be in contrast to the depredations of aging, rather than a specific age of the human lifespan. Eternal youth is common in mythology, and is a popular theme in fiction. Religion and mythology Eternal youth is a characteristic of the inhabitants of Paradise in Abrahamic religions. The Hindus believe that the Vedic and the post-Vedic rishis have attained immortality, which implies the ability to change one's body's age or even shape at will. These are some of the siddhas in Yoga. Markandeya is said to always stay at the age of 16. The difference between eternal life and the more specific eternal youth is a recurrent theme in Greek and Roman mythology. The mytheme of requesting the boon of immortality from a god, but forgetting to ask for eternal youth appears in the story of Tithonus. A similar theme is found in Ovid regarding the Cumaean Sibyl. In Norse mytholo ...
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Traditional Chinese Medicine
Traditional Chinese medicine (TCM) is an alternative medicine, alternative medical practice drawn from traditional medicine in China. A large share of its claims are pseudoscientific, with the majority of treatments having no robust evidence of effectiveness or logical mechanism of action. Some TCM ingredients Traditional Chinese medicine#Safety, are known to be toxic and cause disease, including cancer. Medicine in traditional China encompassed a range of sometimes competing health and healing practices, folk beliefs, Scholar-official, literati theory and Confucianism, Confucian philosophy, Chinese herbology, herbal remedies, Chinese food therapy, food, diet, exercise, medical specializations, and schools of thought. TCM as it exists today has been described as a largely 20th century invention. In the early twentieth century, Chinese cultural and political modernizers worked to eliminate traditional practices as backward and unscientific. Traditional practitioners then selec ...
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Traditional Tibetan Medicine
Traditional Tibetan medicine or Sowa Rigpa is the Tibetan medical system developed in the 8th century under King Trisong Detsen that incorporated the best international medical practices of that time.Claude Arpi, ''Glimpses on the Tibet History'', "Sowa Rigpa" (Art of Healing). Dharamsala: The Tibet Museum, 2016, Chapter 9 The medical treatise ''Giyud Shi'', or the ''Four Tantras'', was then originally composed and later edited in the 12th century. Tibetan medicine employs multiple approaches to diagnosis that incorporate techniques including Venesection, Moxibustion, Compression Therapy, Medicinal Bathing, and massage. The pharmacology relies on complex formulas of multi-ingredient medicines that use herbs, minerals, metals, and animal products. The Tibetan medical system's Four Tantras was based on Tibet's indigenous health practices, and this knowledge joined that of the 8th century invited conference attendants arriving from Greece, Persia, India, China, and Central Asia th ...
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Ophiocordyceps Sinensis
''Ophiocordyceps sinensis'' (synonym (taxonomy), synonym ''Cordyceps sinensis''), known colloquially as caterpillar fungus, is an entomopathogenic fungus (a fungus that grows on insects) in the family Ophiocordycipitaceae. It is mainly found in the meadows above on the Tibetan Plateau in Tibet and the Himalayan regions of Bhutan, India, and Nepal. It parasite, parasitizes larvae of Hepialidae, ghost moths and produces a sporocarp (fungi), fruiting body which is valued in traditional Chinese medicine as an aphrodisiac. However, naturally harvested fruiting bodies often contain high amounts of arsenic and other heavy metals, making them potentially toxic. As a result, their sale has been strictly regulated by China's State Administration for Market Regulation since 2016. ''O. sinensis'' parasitizes the larvae of moths within the family Hepialidae, specifically genera found on the Tibetan Plateau and in the Himalayas, between elevations of . The fungus germinates in the living l ...
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