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Contraceptive Trials In Puerto Rico
The first large-scale Human subject research, human trial of the birth control pill was unethically conducted by Gregory Pincus and John Rock (American scientist), John Rock in 1955 in Puerto Rico. Before the drug was approved as safe in the mainland U.S., many poor and uneducated Puerto Rican women were used as guinea pigs by Gregory and John. These trials are a major component in the history of the development of female oral contraceptive pill, oral contraceptives, occurring in between initial small trial testing on the east coast and the release of the drug for public consumption. As a result, women gained more independence as they were able to delay pregnancies. The trials are controversial because the Puerto Rican women were uninformed of the potential health and safety risks of the drug. There was a large amount of criticism coming from feminist circles surrounding the trial. American testing surrounding the Puerto Rico trials In 1873, the United States federal government ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Human Subject Research
Human subject research is systematic, scientific investigation that can be either interventional (a "trial") or observational (no "test article") and involves human beings as research subjects, commonly known as test subjects. Human subject research can be either medical (clinical) research or non-medical (e.g., social science) research. Systematic investigation incorporates both the collection and analysis of data in order to answer a specific question. Medical human subject research often involves analysis of biological specimens, epidemiological and behavioral studies and medical chart review studies. (A specific, and especially heavily regulated, type of medical human subject research is the "clinical trial", in which drugs, vaccines and medical devices are evaluated.) On the other hand, human subject research in the social sciences often involves surveys which consist of questions to a particular group of people. Survey methodology includes questionnaires, interviews, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Progesterone
Progesterone (; P4) is an endogenous steroid and progestogen sex hormone involved in the menstrual cycle, pregnancy, and embryogenesis of humans and other species. It belongs to a group of steroid hormones called the progestogens and is the major progestogen in the body. Progesterone has a variety of important functions in the body. It is also a crucial metabolic intermediate in the production of other endogenous steroids, including the sex hormones and the corticosteroids, and plays an important role in brain function as a neurosteroid. In addition to its role as a natural hormone, progesterone is also used as a medication, such as in combination with estrogen for contraception, to reduce the risk of Uterine cancer, uterine or cervical cancer, in hormone replacement therapy, and in feminizing hormone therapy. It was first prescribed in 1934. Biological activity Progesterone is the most important progestogen in the body. As a potent agonist of the progesterone receptor, nu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Menstrual Disorder
A menstrual disorder is characterized as any abnormal condition with regards to a woman's menstrual cycle. There are many different types of menstrual disorders that vary with signs and symptoms, including pain during menstruation, heavy bleeding, or absence of menstruation. Normal variations can occur in menstrual patterns but generally menstrual disorders can also include periods that come sooner than 21 days apart, more than 3 months apart, or last more than 10 days in duration. Variations of the menstrual cycle are mainly caused by the immaturity of the hypothalamic-pituitary-ovarian (HPO) axis, and early detection and management is required in order to minimize the possibility of complications regarding future reproductive ability. Though menstrual disorders were once considered more of a nuisance problem, they are now widely recognized as having a serious impact on society in the form of days lost from work brought about by the pain and suffering experienced by women. These di ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Combined Oral Contraceptive Pill
The combined oral contraceptive pill (COCP), often referred to as the birth control pill or colloquially as "the pill", is a type of birth control that is designed to be Oral administration, taken orally by women. It is the oral form of combined hormonal contraception. The pill contains two important hormones: a progestin (a synthetic form of the hormone progestogen / progesterone) and Estrogen (medication), estrogen (usually ethinylestradiol or Estradiol, 17β estradiol). When taken correctly, it alters the menstrual cycle to eliminate ovulation and prevent pregnancy. Combined oral contraceptive pills were first approved for contraceptive use in the United States in 1960, and remain a very popular form of birth control. They are used by more than 100 million women worldwide including about 9 million women in the United States. From 2015 to 2017, 12.6% of women aged 15–49 in the US reported using combined oral contraceptive pills, making it the second most common method of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Estrogen
Estrogen (also spelled oestrogen in British English; see spelling differences) is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent. Another estrogen called estetrol (E4) is produced only during pregnancy. Estrogens are synthesized in all vertebrates and some insects. Quantitatively, estrogens circulate at lower levels than androgens in both men and women. While estrogen levels are significantly lower in males than in females, estrogens nevertheless have important physiological roles in males. Like all steroid hormones, estrogens readily diffuse across the cell membrane. Once inside the cell, they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enovid
Mestranol/norethynodrel was the first combined oral contraceptive pill (COCP) being mestranol and norethynodrel. It sold as Enovid in the United States and as Enavid in the United Kingdom. Developed by Gregory Pincus at G. D. Searle & Company, it was first approved on June 10, 1957, by the U.S. Food and Drug Administration for treatment of menstrual disorders. The FDA approved an additional indication for use as a contraceptive on June 23, 1960, though it only became legally prescribable nationwide and regardless of the woman's marital status after ''Eisenstadt v. Baird'' in 1972. In 1961, it was approved as a contraceptive in the UK and in Canada. Medical uses Mestranol/noretynodrel was indicated in the treatment of gynecological and menstrual disorders. Originally it was not legal to use contraception so it was marketed for menstrual relief with the side effect of inability to conceive. It has also been used to suppress lactation and to treat endometriosis in women. Availa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bottle Of Enovid 10 Mg Oral Contraceptive - DPLA - 0cc9d42b69b6fd3d586205f5831cade0
A bottle is a narrow-necked container made of an impermeable material (such as glass, plastic or aluminium) in various shapes and sizes that stores and transports liquids. Its mouth, at the bottling line, can be sealed with an internal stopper, an external bottle cap, a closure, or induction sealing. Etymology First attested in 14th century. From the English word ''bottle'' derives from an Old French word ''boteille'', from vulgar Latin">-4; we might wonder whether there's a point at which it's appropriate to talk of the beginnings of French, that is, when it wa ... word ''boteille'', from vulgar Latin ''butticula'', from late Latin ''buttis'' ("cask"), a Latinisation (literature), latinisation of the Greek language, Greek βοῦττις (''bouttis'') ("vessel"). Types Glass Wine The glass bottle represented an important development in the history of wine, because, when combined with a high-quality stopper such as a cork, it allowed long-term aging of wine. Glass has ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The New York Times
''The New York Times'' (''NYT'') is an American daily newspaper based in New York City. ''The New York Times'' covers domestic, national, and international news, and publishes opinion pieces, investigative reports, and reviews. As one of the longest-running newspapers in the United States, the ''Times'' serves as one of the country's Newspaper of record, newspapers of record. , ''The New York Times'' had 9.13 million total and 8.83 million online subscribers, both by significant margins the List of newspapers in the United States, highest numbers for any newspaper in the United States; the total also included 296,330 print subscribers, making the ''Times'' the second-largest newspaper by print circulation in the United States, following ''The Wall Street Journal'', also based in New York City. ''The New York Times'' is published by the New York Times Company; since 1896, the company has been chaired by the Ochs-Sulzberger family, whose current chairman and the paper's publ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clarence Gamble
Clarence James Gamble (January 10, 1894 – July 15, 1966) was an American medical doctor and the heir of the Procter and Gamble soap company fortune. He was an advocate of birth control and eugenics, and he founded Pathfinder International. Biography In 1929 Gamble gave $5,000 to open a maternal health clinic in Cincinnati, Ohio. In January 1914, on his 21st birthday, he received his first million dollars. As the grandson of James Gamble, co-founder of Procter & Gamble, he was an heir to family money, which came with a stipulation that at least 10 percent was to be devoted to charitable giving. He later increased this to 30 percent. After graduating from Princeton University in 1914 and Harvard Medical School in 1920, Gamble began his residency at Massachusetts General Hospital. In 1923, he secured an apprenticeship with Alfred Newton Richards, director of the Department of Pharmacology at the University of Pennsylvania, but he did not work with Richards as his plans we ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Procter & Gamble
The Procter & Gamble Company (P&G) is an American multinational consumer goods corporation headquartered in Cincinnati, Ohio. It was founded in 1837 by William Procter and James Gamble. It specializes in a wide range of personal health/consumer health, personal care and hygiene products; these products are organized into several segments including beauty; grooming; health care; fabric and home care; and baby, feminine, and family care. Before the sale of Pringles and Duracell to Kellogg's and Berkshire Hathaway, respectively, its product portfolio also included food, snacks, beverages, and batteries. P&G is incorporated in Ohio. In 2014, P&G recorded $83.1 billion in sales. On August 1, 2014, P&G announced it was streamlining the company, dropping and selling off around 100 brands from its product portfolio in order to focus on the remaining 65 brands, which produced 95% of the company's profits. A.G. Lafley, the company's chairman and CEO until October 2015, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
New Deal
The New Deal was a series of wide-reaching economic, social, and political reforms enacted by President Franklin D. Roosevelt in the United States between 1933 and 1938, in response to the Great Depression in the United States, Great Depression, which had started in 1929. Roosevelt introduced the phrase upon accepting the Democratic Party (United States), Democratic Party's presidential nomination in 1932 before winning the election in a landslide over incumbent Herbert Hoover, whose administration was viewed by many as doing too little to help those affected. Roosevelt believed that the depression was caused by inherent market instability and too little demand per the Keynesian model of economics and that massive government intervention was necessary to stabilize and rationalize the economy. During First 100 days of the Franklin D. Roosevelt presidency, Roosevelt's first hundred days in office in 1933 until 1935, he introduced what historians refer to as the "First New Deal", ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Río Piedras, Puerto Rico
Río Piedras () (Spanish language, Spanish for ''stones river'') is a highly urbanized commercial and residential district in San Juan, Puerto Rico, San Juan, the capital Municipalities of Puerto Rico, municipality of Puerto Rico. Adjacent to the Hato Rey business center and concentrated in the Barrios of San Juan, Puerto Rico, barrios of Pueblo, San Juan, Puerto Rico, Pueblo, Universidad, San Juan, Puerto Rico, Universidad, Hato Rey Sur, El Cinco, San Juan, Puerto Rico, El Cinco, and Monacillo Urbano, San Juan, Puerto Rico, Monacillo Urbano, it is about from the Old San Juan historic quarter, Condado (Santurce), Condado and Isla Verde, Puerto Rico, Isla Verde resort areas, and Luis Muñoz Marín International Airport, SJU airport. It has been the home of the University of Puerto Rico at Rio Piedras, main campus of the University of Puerto Rico since 1903, earning the popular name of ''Ciudad Universitaria'' (college town). The largest health institution in the Geography of Puert ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
