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Clostridium Novyi-NT
''Clostridium novyi''-NT is an attenuated form of '' Clostridium novyi'' that is under investigation as a cancer treatment. It is one of several pathogenic species of ''Clostridium'' bacteria that have been examined for this purpose. The modification eliminated the secretion of α-toxin. Mechanism of action Syngeneic and xenograft experimental tumors across multiple animal species were treated with injected or intravenous ''C. novyi''-NT spores, including colon and pancreatic cancers in mice, aggressive squamous cell carcinoma in rabbits, and glioblastomas in rats. Effects included hemorrhagic necrosis, tumor cell lysis, and tumor regression. Intratumoral application increased spore concentrations in the tumor and reduced side effects. Bacteriolysis in hypoxic tumor parts can be combined with chemotherapy and/or radiation that are more effective in proliferating, non-hypoxic areas at the cost of increased toxicity. Normal cells are generally not hypoxic, preventing these ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clostridium Novyi
''Clostridium novyi'' (oedematiens) a Gram-positive, endospore- forming, obligate anaerobic bacteria of the class Clostridia. It is ubiquitous, being found in the soil and faeces. It is pathogenic, causing a wide variety of diseases in man and animals. Growth in culture proceeds through 3 stages: Initial growth wherein no toxin is produced; vigorous growth wherein toxin is produced; and spore formation wherein endospores are formed and toxin production decreases. It is suggested that type C may be type B that forms spores more readily so does not go through the toxin-production stage. Isolating and identifying ''C novyi'' is difficult due to its extreme anaerobic nature. Commercial kits may not be adequate. It is also fastidious and difficult to culture, requiring the presence of thiols. Taxonomy ''Clostridium novyi'' is considered to be made up from three clades, labelled A, B and C, distinguished by the range of toxins they produce. While strains of type C were not linked to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anaerobic Bacteria
An anaerobic organism or anaerobe is any organism that does not require molecular oxygen for growth. It may react negatively or even die if free oxygen is present. In contrast, an aerobic organism (aerobe) is an organism that requires an oxygenated environment. Anaerobes may be unicellular (e.g. protozoans, bacteria) or multicellular. Most fungi are obligate aerobes, requiring oxygen to survive. However, some species, such as the Chytridiomycota that reside in the rumen of cattle, are obligate anaerobes; for these species, anaerobic respiration is used because oxygen will disrupt their metabolism or kill them. Deep waters of the ocean are a common anoxic environment. First observation In his letter of 14 June 1680 to The Royal Society, Antonie van Leeuwenhoek described an experiment he carried out by filling two identical glass tubes about halfway with crushed pepper powder, to which some clean rain water was added. Van Leeuwenhoek sealed one of the glass tubes using a flame an ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clostridium Beijerinckii
''Clostridium beijerinckii'' is a gram positive, rod shaped, motile bacterium of the genus ''Clostridium''. It has been isolated from feces and soil. Produces oval to subterminal spores. it is named after Martinus Beijerinck who is a Dutch bacteriologist. Industrially interesting for its ability to produce butanol, acetone and/or isopropanol at strictly anaerobic conditions at 37 °C using a wide range of substrates including (but not limited to) pentoses, hexoses and starch. Its ability to grow in simple, inexpensive media, stability in regard to strain degeneration, good adaptability to continuous processes and sustained production of solvents well into the log phase are other advantages of this bacterium. Recent developments have shown it is a possible candidate for efficient hydrogen production. See also * ''Clostridium acetobutylicum'' * Butanol * A.B.E. process Abe or ABE may refer to: People and fictional characters * Shinzo Abe (1954–2022), former Prime Minist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clostridium Histolyticum
''Hathewaya histolytica'' (formerly ''Clostridium histolyticum'') is a species of bacteria found in feces and the soil. It is a motile, gram-positive, aerotolerant anaerobe. ''H. histolytica'' is pathogenic in many species, including guinea pigs, mice, and rabbits, and humans. ''H. histolytica'' has been shown to cause gas gangrene, often in association with other bacteria species. History In 1916, Weinberg and Séguin isolated this bacterium from patients with gas gangrene and called it ''Bacillus histolyticus''. They discovered this bacterium was pathogenic for guinea pigs, mice, and rabbits, but less so for rats. Intramuscular injection of culture caused extensive local tissue destruction, extrusion of a hemorrhagic muscle pulp, splitting of the skin, denudation of the bone, and sometimes autoamputation. In 1922, Heller renamed the bacterium ''Weinbergillus histolyticus'', and a year later Bergey, Harrison, et al. reclassified it as ''Clostridium histolyticum''. Microbio ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clostridium Butyricum
''Clostridium butyricum'' is a strictly anaerobic endospore-forming Gram-positive butyric acid–producing bacillus subsisting by means of fermentation using an intracellularly accumulated amylopectin-like α- polyglucan (granulose) as a substrate. It is uncommonly reported as a human pathogen and is widely used as a probiotic in Asia (particularly in Japan, Korea and China). ''C. butyricum'' is a soil inhabitant in various parts of the world, has been cultured from the stool of healthy children and adults, and is common in soured milk and cheeses. The connection with dairy products is shown by the name: the ''butyr-'' in ''butyricum'' reflects the relevance of butyric acid in the bacteria's metabolism and the connection with Latin '' butyrum'' and Greek '' βούτυρον'', with word roots pertaining to butter and cheese. Industrial relevance The study of fermentation in the 19th century was of interest not only to basic science but also as applied science funded by compa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Salmonella Typhimurium
''Salmonella enterica'' subsp. ''enterica'' is a subspecies of ''Salmonella enterica'', the rod-shaped, flagellated, aerobic, Gram-negative bacterium. Many of the pathogenic serovars of the ''S. enterica'' species are in this subspecies, including that responsible for typhoid. Serovars ''S. enterica'' subsp. ''enterica'' contains a large number of serovars which can infect a broad range of vertebrate hosts. The individual members range from being highly host-adapted (only able to infect a narrow range of species) to displaying a broad host range. A number of techniques are currently used to differentiate between serotypes. These include looking for the presence or absence of antigens, phage typing, molecular fingerprinting and biotyping, where serovars are differentiated by which nutrients they are able to ferment. A possible factor in determining the host range of particular serovars is phage-mediated acquisition of a small number of genetic elements that enable infection of a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Phase 1 Clinical Trial
The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment. For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective. Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays. Summary Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years. If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population. Phase IV trials are 'post-marketing' or 'surveillance' studies conducted to monitor safety over sever ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Los Angeles Times
The ''Los Angeles Times'' (abbreviated as ''LA Times'') is a daily newspaper that started publishing in Los Angeles in 1881. Based in the LA-adjacent suburb of El Segundo since 2018, it is the sixth-largest newspaper by circulation in the United States. The publication has won more than 40 Pulitzer Prizes. It is owned by Patrick Soon-Shiong and published by the Times Mirror Company. The newspaper’s coverage emphasizes California and especially Southern California stories. In the 19th century, the paper developed a reputation for civic boosterism and opposition to labor unions, the latter of which led to the bombing of its headquarters in 1910. The paper's profile grew substantially in the 1960s under publisher Otis Chandler, who adopted a more national focus. In recent decades the paper's readership has declined, and it has been beset by a series of ownership changes, staff reductions, and other controversies. In January 2018, the paper's staff voted to unionize ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Myosarcoma
Myosarcoma is a malignant muscle tumor. People with myosarcoma often wake up with the feeling as if they had a cramp during their sleep. Leiomyosarcoma is sarcoma of smooth muscle, and rhabdomyosarcoma is sarcoma of striated muscle Striations means a series of ridges, furrows or linear marks, and is used in several ways: * Glacial striation * Striation (fatigue), in material * Striation (geology), a ''striation'' as a result of a geological fault * Striation Valley, in An .... However, the term myosarcoma itself still appears in the literature. References External links Sarcoma {{neoplasm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Time (magazine)
''Time'' (stylized in all caps) is an American news magazine based in New York City. For nearly a century, it was published Weekly newspaper, weekly, but starting in March 2020 it transitioned to every other week. It was first published in New York City on March 3, 1923, and for many years it was run by its influential co-founder, Henry Luce. A European edition (''Time Europe'', formerly known as ''Time Atlantic'') is published in London and also covers the Middle East, Africa, and, since 2003, Latin America. An Asian edition (''Time Asia'') is based in Hong Kong. The South Pacific edition, which covers Australia, New Zealand, and the Pacific Islands, is based in Sydney. Since 2018, ''Time'' has been published by Time USA, LLC, owned by Marc Benioff, who acquired it from Meredith Corporation. History ''Time'' has been based in New York City since its first issue published on March 3, 1923, by Briton Hadden and Henry Luce. It was the first weekly news magazine in the United St ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sarcoma
A sarcoma is a malignant tumor, a type of cancer that arises from transformed cells of mesenchymal (connective tissue) origin. Connective tissue is a broad term that includes bone, cartilage, fat, vascular, or hematopoietic tissues, and sarcomas can arise in any of these types of tissues. As a result, there are many subtypes of sarcoma, which are classified based on the specific tissue and type of cell from which the tumor originates. Sarcomas are ''primary'' connective tissue tumors, meaning that they arise in connective tissues. This is in contrast to ''secondary'' (or "metastatic") connective tissue tumors, which occur when a cancer from elsewhere in the body (such as the lungs, breast tissue or prostate) spreads to the connective tissue. The word ''sarcoma'' is derived from the Greek σάρκωμα ''sarkōma'' "fleshy excrescence or substance", itself from σάρξ ''sarx'' meaning "flesh". Classification Sarcomas are typically divided into two major groups: bone sa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Canidae
Canidae (; from Latin, ''canis'', "dog") is a family (biology), biological family of dog-like carnivorans, colloquially referred to as dogs, and constitutes a clade. A member of this family is also called a canid (). There are three subfamily, subfamilies found within the canid family, which are the extinct Borophaginae and Hesperocyoninae, and the extant Caninae. The Caninae are known as canines, and include Dog, domestic dogs, Wolf, wolves, Coyote, coyotes, foxes, jackals and other extant and extinct species. Canids are found on all continents except Antarctica, having arrived independently or accompanied Human, human beings over extended periods of time. Canids vary in size from the gray wolf to the fennec fox. The body forms of canids are similar, typically having long muzzles, upright ears, teeth adapted for cracking bones and slicing flesh, long legs, and bushy tails. They are mostly social animals, living together in family units or small groups and behaving cooperativ ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
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