|
Centre For Protein Engineering
{{Use dmy dates, date=April 2022 The MRC Centre for Protein Engineering (or CPE) was a pioneering research unit in Cambridge, England, with a main focus on the structure, stability and activity of proteins and engineering of antibodies. Centre for Protein Engineering was established in 1990 as one of the MRC's first interdisciplinary research centres and one of the first research laboratories to bring together molecular biology, molecular genetics, biophysics and structural biology into one cohesive unit. It was formed around the research of two prominent scientists who invented protein engineering, Sir Alan Fersht and Sir Greg Winter. Sir Alan Fersht was Director of the MRC CPE from 1990 to 2010, with Greg Winter as Deputy Director. Both, Sir Alan Fersht and Sir Greg Winter were knighted in recognition of their work and for their outstanding contributions to science. From 1990 to 2010 the unit has been extremely successful, both academically and commercially. All of Sir Alan's work ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cambridge
Cambridge ( ) is a university city and the county town in Cambridgeshire, England. It is located on the River Cam approximately north of London. As of the 2021 United Kingdom census, the population of Cambridge was 145,700. Cambridge became an important trading centre during the Roman and Viking ages, and there is archaeological evidence of settlement in the area as early as the Bronze Age. The first town charters were granted in the 12th century, although modern city status was not officially conferred until 1951. The city is most famous as the home of the University of Cambridge, which was founded in 1209 and consistently ranks among the best universities in the world. The buildings of the university include King's College Chapel, Cavendish Laboratory, and the Cambridge University Library, one of the largest legal deposit libraries in the world. The city's skyline is dominated by several college buildings, along with the spire of the Our Lady and the English Marty ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jane Clarke (scientist)
Jane Clarke (née Morgan; born 1950) is an English biochemist and academic. Since October 2017, she has served as President of Wolfson College, Cambridge. She is also Professor of Molecular Biophysics, a Wellcome Trust Senior Research Fellow in the Department of Chemistry at the University of Cambridge. She was previously a Fellow of Trinity Hall, Cambridge. Early life and education Clarke was born Jane Morgan in London on 10 September 1950. She was educated at the University of York where she graduated with a first-class honours degree in biochemistry in 1972. She went on to study for a Postgraduate Certificate in Education (PGCE) at the University of Cambridge in 1973. Clarke was a science teacher in several secondary schools, and a Head of Science at Northumberland Park School, Tottenham, from 1973 to 1986. Clarke married Christopher Clarke in 1973 with whom she would go on to have one son and one daughter. He obtained a job in the United States and the family moved t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Institutions Of The University Of Cambridge
Institutions are humanly devised structures of rules and norms that shape and constrain individual behavior. All definitions of institutions generally entail that there is a level of persistence and continuity. Laws, rules, social conventions and norms are all examples of institutions. Institutions vary in their level of formality and informality. Institutions are a principal object of study in social sciences such as political science, anthropology, economics, and sociology (the latter described by Émile Durkheim as the "science of institutions, their genesis and their functioning"). Primary or meta-institutions are institutions such as the family or money that are broad enough to encompass sets of related institutions. Institutions are also a central concern for law, the formal mechanism for political rule-making and enforcement. Historians study and document the founding, growth, decay and development of institutions as part of political, economic and cultural hist ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Former Research Units Of The Medical Research Council (United Kingdom)
A former is an object, such as a template, gauge or cutting die, which is used to form something such as a boat's hull. Typically, a former gives shape to a structure that may have complex curvature. A former may become an integral part of the finished structure, as in an aircraft fuselage, or it may be removable, being using in the construction process and then discarded or re-used. Aircraft formers Formers are used in the construction of aircraft fuselage, of which a typical fuselage has a series from the nose to the empennage, typically perpendicular to the longitudinal axis of the aircraft. The primary purpose of formers is to establish the shape of the fuselage and reduce the column length of stringers to prevent instability. Formers are typically attached to longerons, which support the skin of the aircraft. The "former-and-longeron" technique (also called stations and stringers) was adopted from boat construction, and was typical of light aircraft built until the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biological Research Institutes In The United Kingdom
Biology is the scientific study of life. It is a natural science with a broad scope but has several unifying themes that tie it together as a single, coherent field. For instance, all organisms are made up of cells that process hereditary information encoded in genes, which can be transmitted to future generations. Another major theme is evolution, which explains the unity and diversity of life. Energy processing is also important to life as it allows organisms to move, grow, and reproduce. Finally, all organisms are able to regulate their own internal environments. Biologists are able to study life at multiple levels of organization, from the molecular biology of a cell to the anatomy and physiology of plants and animals, and evolution of populations.Based on definition from: Hence, there are multiple subdisciplines within biology, each defined by the nature of their research questions and the tools that they use. Like other scientists, biologists use the scientific ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gregory Winter
Sir Gregory Paul Winter (born 14 April 1951) is a Nobel Prize-winning English molecular biologist best known for his work on the therapeutic use of monoclonal antibodies. His research career has been based almost entirely at the MRC Laboratory of Molecular Biology and the MRC Centre for Protein Engineering, in Cambridge, England. He is credited with having invented techniques to both humanise (1986) and, later, to fully humanise using phage display, antibodies for therapeutic uses.ThScientific Founders of Bicycle Therapeutics Ltd. – Christian Heinis and Sir Greg Winter, FRS. Previously, antibodies had been derived from mice, which made them difficult to use in human therapeutics because the human immune system had anti-mouse reactions to them. For these developments Winter was awarded the 2018 Nobel Prize in Chemistry along with George Smith and Frances Arnold. He is a Fellow of Trinity College, Cambridge and was appointed Master of Trinity College, Cambridge on 2 Octob ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Dan Tawfik
Dan Salah Tawfik (28 May 1955 – 4 May 2021) was an Israeli biochemist, best known for his contributions in protein engineering, evolutionary biochemistry and, more particularly, enzyme evolution. Biography Tawfik was born in Jerusalem to a family of Jewish immigrants originally from Iraq. He received his BSc in chemistry and biochemistry (1988) and MSc in biotechnology (1990) from the Hebrew University in Jerusalem, and his PhD from the Weizmann Institute of Science (1995). He then moved to the United Kingdom where, after two years of postdoctoral research working under Alan Fersht at the University of Cambridge (UK) and at the Medical Research Council (MRC) Centre for Protein Engineering, he became a senior research fellow at Sidney Sussex College and at the Centre for Protein Engineering, where he was appointed group leader in 1999. In 2001 he joined the Department of Biological Chemistry (now called the Department of Biomolecular Sciences) at the Weizmann Institute ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Andreas Matouschek
Andreas Matouschek is a biochemist at The University of Texas at Austin, where he is a professor in the College of Natural Sciences. His graduate work with Alan Fersht resulted in the seminal application of phi-value analysis to the study of barnase, a bacterial RNAse used in many protein folding studies. Development of phi value analysis in combination with extensive protein engineering enabled an understanding of the kinetic intermediates during protein folding of barnase. In subsequent postdoctoral work at the University of Basel, he studied how mitochondria refold proteins after importing them. In 1996, he moved to Northwestern University. In 2012, he moved to The University of Texas at Austin. Matouschek currently studies the proteasome, the degradation machinery of eukaryotic cells, and the mechanisms by which the proteasome is able to unfold and translocate proteins. Scientific career Cambridge (1988-1993) At Cambridge, Matouschek was a graduate student under Sir Alan F ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tim Hubbard
Timothy John Phillip Hubbard is a Professor of Bioinformatics at King's College London, Head of Genome Analysis at Genomics England and Honorary Faculty at the Wellcome Trust Sanger Institute in Cambridge, UK. Education Hubbard was educated at the University of Cambridge where he was awarded a Bachelor of Arts degree in Natural Sciences (Biochemistry) in 1985. He went on to do research in protein design in the Department of Crystallography, Birkbeck College, London where he was awarded a PhD in 1988 for research supervised by Tom Blundell. Research and career Hubbard's research interests are in Bioinformatics, Computational biology and Genome Informatics. During his tenure at WTSI he supervised several successful PhD students to completion in these areas of research. Hubbard was appointed Professor of Bioinformatics at King's in October 2013. His research has been published in leading peer reviewed scientific journals including '' Nature'', the ''Journal of Molecular Bi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cyrus Chothia
Cyrus Homi Chothia (19 February 1942 – 26 November 2019) was an English biochemist who was an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge and emeritus fellow of Wolfson College, Cambridge. Education Chothia was educated at Alleyn's School, then went to study at Durham University graduating with a Bachelor of Science degree in 1965. Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a PhD from University College London under the supervision of , the son of Linus Pauling. Research and career After his PhD Chothia worked in the Laboratory of Molecular Biology (LMB) for three years. He then worked with Michael Levitt at the Weizmann Institute of Science followed by two years with Joel Janin at the Institut Pasteur in Paris. In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur Lesk he showed that proteins adapt to mutati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
England
England is a country that is part of the United Kingdom. It shares land borders with Wales to its west and Scotland to its north. The Irish Sea lies northwest and the Celtic Sea to the southwest. It is separated from continental Europe by the North Sea to the east and the English Channel to the south. The country covers five-eighths of the island of Great Britain, which lies in the North Atlantic, and includes over 100 smaller islands, such as the Isles of Scilly and the Isle of Wight. The area now called England was first inhabited by modern humans during the Upper Paleolithic period, but takes its name from the Angles, a Germanic tribe deriving its name from the Anglia peninsula, who settled during the 5th and 6th centuries. England became a unified state in the 10th century and has had a significant cultural and legal impact on the wider world since the Age of Discovery, which began during the 15th century. The English language, the Anglican Church, and Eng ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Laboratory Of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical research laboratory at the forefront of scientific discovery, dedicated to improving the understanding of key biological processes at atomic, molecular and cellular levels using multidisciplinary methods, with a focus on using this knowledge to address key issues in human health. A new replacement building constructed close by to the original site on the Cambridge Biomedical Campus was opened by Her Majesty the Queen in May 2013. The road outside the new building is named Francis Crick Avenue after the 1962 joint Nobel Prize winner and LMB alumnus, who co-discovered the helical structure of DNA in 1953. History Origins: 1947-61 Max Perutz, following undergraduate training in organic chemistry, left Austria in 1936 and came to the Univers ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
.jpg "Click for more on -> Gregory Winter")
