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Cancer Detection
The objective of cancer screening is to detect cancer before symptoms appear, involving various methods such as blood tests, urine tests, DNA tests, and medical imaging. The purpose of screening is early cancer detection, to make the cancer easier to treat and extending life expectancy. In 2019, cancer was the second leading cause of death globally; more recent data is pending due to the COVID-19 pandemic. Universal screening, also known as mass screening or population screening, involves the screening of individuals within certain age and gender groups, aiming to screen the population for particular cancers or cancer risk factors. Selective screening, also known as targeted screening, identifies individuals with a higher risk of developing cancer, including individuals with a family history (genetic risk) of cancer or individuals engaging in high-risk behaviors such as smoking. The act of cancer screening plays a pivotal role in both preventing cancer and providing early diagn ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breast Cancer
Breast cancer is a cancer that develops from breast tissue. Signs of breast cancer may include a Breast lump, lump in the breast, a change in breast shape, dimpling of the skin, Milk-rejection sign, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a red or scaly patch of skin. In those with Metastatic breast cancer, distant spread of the disease, there may be bone pain, swollen lymph nodes, shortness of breath, or yellow skin. Risk factors for developing breast cancer include obesity, a Sedentary lifestyle, lack of physical exercise, alcohol consumption, hormone replacement therapy during menopause, ionizing radiation, an early age at Menarche, first menstruation, having children late in life (or not at all), older age, having a prior history of breast cancer, and a family history of breast cancer. About five to ten percent of cases are the result of an inherited genetic predisposition, including BRCA mutation, ''BRCA'' mutations among others. Breast ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
PSA Test
PSA, PsA, Psa, or psa may refer to: Biology and medicine * Posterior spinal artery * Primary systemic amyloidosis, a disease caused by the accumulation of abnormal proteins * Prostate-specific antigen, an enzyme used as a blood tracer for prostate cancer * Psoriatic arthritis, an inflammatory disease * ''Pseudomonas aeruginosa'', a species of bacterium * ''Pseudomonas syringae'' pv. ''actinidiae'', a pathovar of a bacterium that attacks kiwifruit Chemistry * Polar surface area, the surface sum over all polar atoms of a molecule * Pressure swing adsorption, a technology for separating, or purifying, gases Computing * Professional services automation, software for automating project and billing management for professional service firms * PSA Certified, Platform Security Architecture, a security certification for the Internet of Things * Plesk Server Administrator, a commercial web hosting automation program * Persistent staging area, a staging area in data vault modelin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mental Disorder
A mental disorder, also referred to as a mental illness, a mental health condition, or a psychiatric disability, is a behavioral or mental pattern that causes significant distress or impairment of personal functioning. A mental disorder is also characterized by a clinically significant disturbance in an individual's cognition, emotional regulation, or behavior, often in a society, social context. Such disturbances may occur as single episodes, may be persistent, or may be relapsing–remitting. There are many different types of mental disorders, with signs and symptoms that vary widely between specific disorders. A mental disorder is one aspect of mental health. The causes of mental disorders are often unclear. Theories incorporate findings from a range of fields. Disorders may be associated with particular regions or functions of the brain. Disorders are usually Medical diagnosis, diagnosed or assessed by a mental health professional, such as a Clinical psychology#Profes ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
End-stage Renal Disease
Chronic kidney disease (CKD) is a type of long-term kidney disease, defined by the sustained presence of abnormal kidney function and/or abnormal kidney structure. To meet criteria for CKD, the abnormalities must be present for at least three months. Early in the course of CKD, patients are usually asymptomatic, but later symptoms may include leg swelling, feeling tired, vomiting, loss of appetite, and confusion. Complications can relate to hormonal dysfunction of the kidneys and include (in chronological order) high blood pressure (often related to activation of the renin–angiotensin system), bone disease, and anemia. Additionally CKD patients have markedly increased cardiovascular complications with increased risks of death and hospitalization. CKD can lead to end-stage kidney failure requiring kidney dialysis or kidney transplantation. Causes of chronic kidney disease include diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease. Risk factors ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Disability-adjusted Life Year
A disability-adjusted life year (DALY) is a measure of overall disease burden, representing a year lost due to ill-health, disability, or early death. It was developed in the 1990s as a way of comparing the overall health and life expectancy of different countries. The concept has become more common in the field of public health and health impact assessment (HIA). It combines both potential years of life lost due to premature death ( mortality) and to poor health or disability ( morbidity) into a single metric. DALY, QALY and HALY DALY is closely related to QALY and HALY. A QALY (quality-adjusted life year) measures both the length and quality of life. QALYs are commonly used to assess the cost-effectiveness of medical or public health interventions and to guide decisions aimed at improving social welfare. However, QALYs measure only the benefit of medical interventions, not the overall burden of disease. Like DALY, HALY (health-adjusted life years) assesses the combined effec ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Years Of Potential Life Lost
Years of potential life lost (YPLL) or potential years of life lost (PYLL) is an estimate of the average years a person would have lived if they had not died prematurely. It is, therefore, a measure of premature mortality. As an alternative to death rates, it is a method that gives more weight to deaths that occur among younger people. An alternative is to consider the effects of both disability and premature death using disability adjusted life years. Calculation To calculate the years of potential life lost, the analyst has to set an upper reference age. The reference age should correspond roughly to the life expectancy of the population under study. In the developed world, this is commonly set at age 75, but it is essentially arbitrary. Thus, PYLL should be written with respect to the reference age used in the calculation: e.g., PYLL 5 PYLL can be calculated using individual level data or using age grouped data. Briefly, for the individual method, each person's PYLL is calcu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lead-time Bias
Lead time bias happens when survival time appears longer because diagnosis was done earlier (for instance, by screening), irrespective of whether the patient lived longer. Lead time is the duration of time between the detection of a disease (by screening or based on new experimental criteria) and its usual clinical presentation and diagnosis (based on traditional criteria). For example, it is the time between early detection by screening and the time when diagnosis would have been made clinically (without screening). It is an important factor when evaluating the effectiveness of a specific test. __TOC__ Relationship between screening and survival The goal of screening is earlier detection (to diagnose a disease earlier than it would be without screening). Therefore, if screening works, it needs to advance in time to the moment of diagnosis. In other words, screening needs to introduce a lead time. However, the lead time itself biases survival statistics: people with diseases ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cancer Survival Rates
Cancer survival rates vary by the type of cancer, stage at diagnosis, treatment given and many other factors, including country. In general survival rates are improving, although more so for some cancers than others. Survival rate can be measured in several ways, median life expectancy having advantages over others in terms of meaning for people involved, rather than as an epidemiological measure. However, survival rates are currently often measured in terms of 5-year survival rates, which is the percentage of people who live at least five years after being diagnosed with cancer, and relative survival rates compare people with cancer to people in the overall population. Several types of cancer are associated with high survival rates, including breast, prostate, testicular and colon cancer. Brain and pancreatic cancers have much lower median survival rates which have not improved as dramatically over the last forty years. Indeed, pancreatic cancer has one of the worst survival r ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Test Sensitivity
Test(s), testing, or TEST may refer to: * Test (assessment), an educational assessment intended to measure the respondents' knowledge or other abilities Arts and entertainment * ''Test'' (2013 film), an American film * ''Test'' (2014 film), a Russian film * ''Test'' (2025 film), an Indian sports drama * Test (group), a jazz collective * ''Tests'' (album), a 1998 album by The Microphones * ''Testing'' (album), an album by ASAP Rocky Computing * .test, a reserved top-level domain * Software testing * test (Unix), a Unix command for evaluating conditional expressions * TEST (x86 instruction), an x86 assembly language instruction People * Test (wrestler), ring name for Andrew Martin (1975–2009), Canadian professional wrestler * John Test (1771–1849), American politician * Zack Test (born 1989), American rugby union player Science and technology * Experiment, a procedure carried out in order to test a hypothesis * Statistical hypothesis test, techniques to reach c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Quality Of Life (healthcare)
In healthcare, quality of life is an assessment of how the individual's well-being may be affected over time by a disease, disability or disorder. Measurement Early versions of healthcare-related quality of life measures referred to simple assessments of physical abilities by an external rater (for example, the patient is able to get up, eat and drink, and take care of personal hygiene without any help from others) or even to a single measurement (for example, the angle to which a limb could be flexed). The current concept of health-related quality of life acknowledges that subjects put their actual situation in relation to their personal expectation. The latter can vary over time, and react to external influences such as length and severity of illness, family support, etc. As with any situation involving multiple perspectives, patients' and physicians' rating of the same objective situation have been found to differ significantly. Consequently, health-related quality of life is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Overdiagnosis
Overdiagnosis is the diagnosis of disease that will never cause symptoms or death during a patient's ordinarily expected lifetime and thus presents no practical threat regardless of being pathologic. Overdiagnosis is a side effect of screening for early forms of disease. Although screening saves lives in some cases, in others it may turn people into patients unnecessarily and may lead to treatments that do no good and perhaps do harm. Given the tremendous variability that is normal in biology, it is inherent that the more one screens, the more incidental findings will generally be found. For a large percentage of them, the most appropriate medical response is to recognize them as something that does not require intervention; but determining which action a particular finding warrants ("ignoring", watchful waiting, or intervention) can be very difficult, whether because the differential diagnosis is uncertain or because the risk ratio is uncertain (risks posed by intervention, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gastrointestinal Perforation
Gastrointestinal perforation, also known as gastrointestinal rupture, is a hole in the wall of the gastrointestinal tract. The gastrointestinal tract is composed of hollow digestive organs leading from the mouth to the anus. Symptoms of gastrointestinal perforation commonly include severe abdominal pain, nausea, and vomiting. Complications include a painful inflammation of the inner lining of the abdominal wall and sepsis. Perforation may be caused by trauma, bowel obstruction, diverticulitis, stomach ulcers, cancer, or infection. A CT scan is the preferred method of diagnosis; however, free air from a perforation can often be seen on plain X-ray. Perforation anywhere along the gastrointestinal tract typically requires emergency surgery in the form of an exploratory laparotomy. This is usually carried out along with intravenous fluids and antibiotics. Occasionally the hole can be sewn closed while other times a bowel resection is required. Even with maximum treatment t ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
