|
Antitoxins
An antitoxin is an antibody with the ability to neutralize a specific toxin. Antitoxins are produced by certain animals, plants, and bacteria in response to toxin exposure. Although they are most effective in neutralizing toxins, they can also kill bacteria and other microorganisms. Antitoxins are made within organisms, and can be injected into other organisms, including humans, to treat an infectious disease. This procedure involves injecting an animal with a safe amount of a particular toxin. The animal's body then makes the antitoxin needed to neutralize the toxin. Later, blood is withdrawn from the animal. When the antitoxin is obtained from the blood, it is purified and injected into a human or other animal, inducing temporary passive immunity. To prevent serum sickness, it is often best to use an antitoxin obtained from the same species (e.g. use human antitoxin to treat humans). Most antitoxin preparations are prepared from donors with high titers of antibody against the ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Toxin-antitoxin System
A toxin-antitoxin system consists of a "toxin" and a corresponding "antitoxin", usually encoded by closely linked genes. The toxin is usually a protein while the antitoxin can be a protein or an RNA. Toxin-antitoxin systems are widely distributed in prokaryotes, and organisms often have them in multiple copies. When these systems are contained on plasmids – transferable genetic elements – they ensure that only the daughter cells that Mendelian inheritance, inherit the plasmid survive after cell division. If the plasmid is absent in a daughter cell, the unstable cell division, antitoxin is degraded and the stable toxic protein kills the new cell; this is known as 'post-segregational killing' Hok/sok system, (PSK). Toxin-antitoxin systems are typically classified according to how the antitoxin neutralises the toxin. In a type I toxin-antitoxin system, the translation (genetics), translation of mRNA, messenger RNA (mRNA) that encodes the toxin is inhibited by the binding ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serum Sickness
Serum sickness in humans is a adverse drug reaction, reaction to proteins in antiserum derived from a non-human animal source, occurring 5–10 days after exposure. Symptoms often include a rash, Arthralgia, joint pain, fever, and lymphadenopathy. It is a type of hypersensitivity, specifically immune complex hypersensitivity (Type III hypersensitivity, type III). The term serum sickness–like reaction (SSLR) is occasionally used to refer to similar illnesses that arise from the introduction of certain non-protein substances, such as penicillin. Serum sickness may be diagnosed based on the symptoms, and using a blood test and a Clinical urine tests, urine test. It may be prevented by not using an antitoxin derived from animal serum, and through prophylactic antihistamines or corticosteroids. It usually resolves naturally, but may be treated with corticosteroids, antihistamines, Analgesic, analgesics, and (in severe cases) prednisone. It was first characterized in 1906. Signs and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serum Therapy
In immunology, antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation ( plasmapheresis). For example, convalescent serum, or passive antibody transfusion from a previous human survivor, was the only known effective treatment for Ebola infection with a high success rate of 7 out of 8 patients surviving. Antisera are widely used in diagnostic virology laboratories. The most common use of antiserum in humans is as antitoxin or antivenom to treat envenomation. Serum therapy, also known as serotherapy, describes the treatment of infectious diseases using the serum of animals that have been immunized against the specific organism or components of that organism that is causing the infection. History In 1890, Emil von Behring and Kitasato Shibasaburō published their first paper on serum therapy. Behring pioneered the technique, using guinea pigs to produce serum. Based on hi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Immune System
The immune system is a network of biological systems that protects an organism from diseases. It detects and responds to a wide variety of pathogens, from viruses to bacteria, as well as Tumor immunology, cancer cells, Parasitic worm, parasitic worms, and also objects such as wood splinters, distinguishing them from the organism's own healthy biological tissue, tissue. Many species have two major subsystems of the immune system. The innate immune system provides a preconfigured response to broad groups of situations and stimuli. The adaptive immune system provides a tailored response to each stimulus by learning to recognize molecules it has previously encountered. Both use humoral immunity, molecules and cell-mediated immunity, cells to perform their functions. Nearly all organisms have some kind of immune system. Bacteria have a rudimentary immune system in the form of enzymes that protect against bacteriophage, viral infections. Other basic immune mechanisms evolved in ancien ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Antiserum
In immunology, antiserum is a blood serum containing antibodies (either monoclonal or polyclonal) that is used to spread passive immunity to many diseases via blood donation ( plasmapheresis). For example, convalescent serum, or passive antibody transfusion from a previous human survivor, was the only known effective treatment for Ebola infection with a high success rate of 7 out of 8 patients surviving. Antisera are widely used in diagnostic virology laboratories. The most common use of antiserum in humans is as antitoxin or antivenom to treat envenomation. Serum therapy, also known as serotherapy, describes the treatment of infectious diseases using the serum of animals that have been immunized against the specific organism or components of that organism that is causing the infection. History In 1890, Emil von Behring and Kitasato Shibasaburō published their first paper on serum therapy. Behring pioneered the technique, using guinea pigs to produce serum. Based ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Jim (horse)
Jim or JIM may refer to: Names * Jim (given name), a given name * Jim, a diminutive form of the given name James * Jim, a short form of the given name Jimmy People and horses * Jim, the nickname of Yelkanum Seclamatan (died April 1911), Native American chief * Juan Ignacio Martínez (born 1964), Spanish footballer, commonly known as JIM * Jim (horse), milk wagon horse used to produce serum containing diphtheria antitoxin * Jim (Medal of Honor recipient) Media and publications * ''Jim'' (book), a book about Jim Brown written by James Toback * ''Jim'' (comics), a series by Jim Woodring * '' Jim!'', an album by rock and roll singer Jim Dale * ''Jim'' (album), by soul artist Jamie Lidell * Jim (''Huckleberry Finn''), a character in Mark Twain's novel * Jim (TV channel), in Finland * Jim (YRF Spy Universe), a fictional film character in the Indian YRF Spy Universe, portrayed by John Abraham * JIM (Flemish TV channel), a Flemish television channel * "Jim" (song), a 1 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vaccination
Vaccination is the administration of a vaccine to help the immune system develop immunity from a disease. Vaccines contain a microorganism or virus in a weakened, live or killed state, or proteins or toxins from the organism. In stimulating the body's Adaptive immune system, adaptive immunity, they help prevent sickness from an infectious disease. When a sufficiently large percentage of a population has been vaccinated, herd immunity results. Herd immunity protects those who may be immunocompromised and cannot get a vaccine because even a weakened version would harm them. The effectiveness of vaccination has been widely studied and verified. Vaccination is the most effective method of preventing infectious diseases; widespread immunity due to vaccination is largely responsible for the Eradication of infectious diseases, worldwide eradication of smallpox and the elimination of diseases such as polio and tetanus from much of the world. According to the World Health Organization ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
George Frederick Dick
George Frederick Dick (July 21, 1881 – October 10, 1967) was an American physician and bacteriologist best known for his work with scarlet fever. Dick studied scarlet fever whilst serving the Army Medical Corps during World War I. Dick continued with his research into scarlet fever following the war, and in 1923, in collaboration with his wife Gladys Rowena Dick, managed to locate the cause of the disease in a toxin produced by a strain of Streptococcus bacteria. Using this, they were able to create an antitoxin for treatment and a non-toxic vaccine for immunization. In 1933, Dick and his wife were awarded the Cameron Prize for Therapeutics of the University of Edinburgh. He was a professor of clinical medicine at Rush Medical College, Chicago (1918–33), and then became the head of the department of medicine at the University of Chicago The University of Chicago (UChicago, Chicago, or UChi) is a Private university, private research university in Chicago, Illinois, Un ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gladys Dick
Gladys Rowena Henry Dick (December 18, 1881 – August 21, 1963) was an American physician who co-developed an antitoxin and vaccine for scarlet fever with her husband, George F. Dick. Biography Gladys Rowena Henry was born in Pawnee City, Nebraska in 1881 and earned her B.S. in zoology from the University of Nebraska–Lincoln in 1900. She was a member of the Pi Beta Phi chapter at the University of Nebraska. Because her mother initially objected to Gladys attending medical school, she took graduate classes at Nebraska until 1903, then moved to Baltimore to attend Johns Hopkins University School of Medicine. Graduating in 1907 with her M.D., she then trained for a year at the University of Berlin. Dick's years at Johns Hopkins and Berlin "marked her introduction to biomedical research" and provided opportunities to study experimental cardiac surgery and blood chemistry with Harvey Cushing, W.G. MacCallum, and Milton Winternitz. Dick moved to Chicago in 1911 and contra ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Scarlet Fever Serum
Scarlet fever serum was used beginning in November 1900 after its development in the Sero-Therapeutic Laboratory of Rudolph Hospital in Vienna, Austria. The serum was taken from the blood of horses. Infected children were injected in their abdominal skin by Dr. Paul Moser. Mortality rates from scarlet fever (also known as scarlatina) declined significantly following the use of the blood serum. Moser at first used scarlet fever serum primarily on the most severely sick persons. After achieving positive results it was applied in the first or second day following contraction of scarlet fever. In many cases the children treated demonstrated great improvement in a very short time, with their fevers going away quickly. Moser worked with four hundred children suffering from scarlatina at St. Anne's Hospital. The mortality rate of those he treated was 8.9%. This compared quite favorably when measured against the 13.09% among children in Vienna hospitals where the scarlet fever serum was no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
First World War
World War I or the First World War (28 July 1914 – 11 November 1918), also known as the Great War, was a World war, global conflict between two coalitions: the Allies of World War I, Allies (or Entente) and the Central Powers. Fighting took place mainly in European theatre of World War I, Europe and the Middle Eastern theatre of World War I, Middle East, as well as in parts of African theatre of World War I, Africa and the Asian and Pacific theatre of World War I, Asia-Pacific, and in Europe was characterised by trench warfare; the widespread use of Artillery of World War I, artillery, machine guns, and Chemical weapons in World War I, chemical weapons (gas); and the introductions of Tanks in World War I, tanks and Aviation in World War I, aircraft. World War I was one of the List of wars by death toll, deadliest conflicts in history, resulting in an estimated World War I casualties, 10 million military dead and more than 20 million wounded, plus some 10 million civilian de ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
