|
Alpha-1 Blockers
Alpha 1 or Alpha-1 may refer to: *Alpha-1 adrenergic receptor, a G protein-coupled receptor *Alpha-1 antitrypsin, a protein **Alpha-1 antitrypsin deficiency Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. Onset of lung problems is typically between 20 and 50 years of age. This may result in shortness of breath, wheezing, or an inc ..., a genetic disorder * Alpha-1-fetoprotein or Alpha-fetoprotein, a protein *Alpha-One, a fictional spacecraft in '' Buzz Lightyear of Star Command: The Adventure Begins'' * ''Alpha 1'' (Robert Silverberg anthology), a 1970 book * Alpha-1 Wrestling, a professional wrestling promotion See also * * * A1 (other) * Alpha (other) * AMY1A or Alpha-1A or, an enzyme found in humans and other mammals * List of A1 genes, proteins or receptors {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Adrenergic Receptor
alpha-1 (α1) adrenergic are G protein-coupled receptors (GPCRs) associated with the Gq alpha subunit, Gq heterotrimeric G protein. α1-adrenergic receptors are subdivided into three highly homologous subtypes, i.e., α1A-adrenergic, α1A-, α1B-adrenergic, α1B-, and α1D-adrenergic, α1D-adrenergic receptor subtypes. There is no α1C receptor. At one time, there was a subtype known as α1C, but it was found to be identical to the previously discovered α1A receptor subtype. To avoid confusion, naming was continued with the letter D. Catecholamines like norepinephrine (noradrenaline) and epinephrine (adrenaline) signal through the α1-adrenergic receptors in the central nervous system, central and peripheral nervous systems. The crystal structure of the α1B-adrenergic receptor subtype has been determined in complex with the inverse agonist (+)-cyclazosin. Effects The α1-adrenergic receptor has several general functions in common with the Alpha-2 adrenergic receptor, α2-adrene ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Antitrypsin
Alpha-1 antitrypsin or α1-antitrypsin (A1AT, α1AT, A1A, or AAT) is a protein belonging to the serpin superfamily. It is encoded in humans by the ''SERPINA1'' gene. A protease inhibitor, it is also known as alpha1–proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it inhibits various proteases (not just trypsin). As a type of enzyme inhibitor, it protects tissues from enzymes of inflammatory cells, especially neutrophil elastase. When the blood contains inadequate or defective A1AT (as in alpha-1 antitrypsin deficiency), neutrophil elastase can excessively break down elastin, leading to the loss of elasticity in the lungs. This results in respiratory issues, such as chronic obstructive pulmonary disease, in adults. Normally, A1AT is produced in the liver and enters the systemic circulation. However, defective A1AT may accumulate in the liver, potentially causing cirrhosis in both adults and children. A1AT not only binds to neutrophil elastase from ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Antitrypsin Deficiency
Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. Onset of lung problems is typically between 20 and 50 years of age. This may result in shortness of breath, wheezing, or an increased risk of lung infections. Complications may include chronic obstructive pulmonary disease (COPD), cirrhosis, neonatal jaundice, or panniculitis. A1AD is due to a mutation in the SERPINA1 gene that results in not enough alpha-1 antitrypsin (A1AT). Risk factors for lung disease include tobacco smoking and Dust, environmental dust. The underlying mechanism involves unblocked neutrophil elastase and buildup of abnormal A1AT in the liver. It is autosomal co-dominant, meaning that one defective allele tends to result in milder deficiency than two defective alleles; for example, carriers with an MS (or SS) allele combination usually produce enough alpha-1 antitrypsin to protect the lungs, while those with MZ alleles have a slightly increas ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1-fetoprotein
Alpha-fetoprotein (AFP, α-fetoprotein; also sometimes called alpha-1-fetoprotein, alpha-fetoglobulin, or alpha fetal protein) is a protein that in humans is encoded by the ''AFP'' gene. The ''AFP'' gene is located on the ''q'' arm of chromosome 4 (4q13.3). Maternal AFP serum level is used to screen for Down syndrome, neural tube defects, and other chromosomal abnormalities. AFP is a major plasma protein produced by the yolk sac and the fetal liver during fetal development. It is thought to be the fetal analog of serum albumin. AFP binds to copper, nickel, fatty acids and bilirubin and is found in monomeric, dimeric and trimeric forms. Structure AFP is a glycoprotein of 591 amino acids and a carbohydrate moiety. Function The function of AFP in adult humans is unknown. AFP is the most abundant plasma protein found in the human fetus. In the fetus, AFP is produced by both the liver and the yolk sac. It is believed to function as a carrier protein (similar to albumin ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
The Adventure Begins
''Thomas & Friends: The Adventure Begins'' is a 2015 animated adventure comedy film and the eighth feature-length special based on the British television series ''Thomas & Friends''. The film was produced and distributed by HIT Entertainment with animation production by Canadian-based Arc Productions. The film functions as a prequel to the show, and a retelling of the first two books of ''The Railway Series''; '' The Three Railway Engines'' and ''Thomas the Tank Engine'', as well as the first seven episodes of the first series. It was made to commemorate the 70th anniversary of ''The Railway Series'', and was the first installment to officially adapt a story from ''The Railway Series'' since series 4. The film also saw John Hasler and Joseph May take over the voice role of Thomas the Tank Engine in the United Kingdom and the United States respectively. The film was first released direct-to-video Direct-to-video or straight-to-video refers to the release of a film, televi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha 1 (Robert Silverberg Anthology)
''Alpha 1'' is a science fiction anthology edited by Robert Silverberg first published in 1970. Stories in ''Alpha 1'' *Introduction by Robert Silverberg *''Poor Little Warrior'' by Brian W. Aldiss *'' The Moon Moth'' by Jack Vance *''Testament of Andros'' by James Blish *''A Triptych'' by Barry N. Malzberg *''For a Breath I Tarry'' by Roger Zelazny *''Game for Motel Room'' by Fritz Leiber Fritz Reuter Leiber Jr. ( ; December 24, 1910 – September 5, 1992) was an American writer of fantasy, horror, and science fiction. Along with Robert E. Howard and Michael Moorcock, Leiber is one of the fathers of sword and sorcery. Life ... *''Thus We Frustrate Charlemagne'' by R. A. Lafferty *''The Man Who Came Early'' by Poul Anderson *''The Time of His Life'' by Larry Eisenberg *''The Doctor'' by Ted Thomas *''Time Trap'' by Charles L. Harness *'' The Pi Man'' by Alfred Bester *''The Last Man Left in the Bar'' by C. M. Kornbluth *''The Terminal Beach'' by J. G. Ballar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha-1 Wrestling
Alpha-1 Wrestling (A1) is a Canadian independent professional wrestling promotion based out of Hamilton, Ontario. The promotion was founded by Ethan Page in 2010 after he grew tired of inviting his family to see him in bars commenting "I just figured I could do a better show myself". It went on hiatus in 2012 for several months after one of the cameras used to tape a wrestling show was stolen, and began a longer one in 2020 as a result of the COVID-19 pandemic The COVID-19 pandemic (also known as the coronavirus pandemic and COVID pandemic), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), began with an disease outbreak, outbreak of COVID-19 in Wuhan, China, in December .... It resumed its operations in February 2024 and still continues to do so despite its founder Ethan Page joining WWE in May of the same year. Current champions As of , References External links Alpha-1 Wrestling (A1)Official Website {{Professional wrestling in Cana ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
A1 (other)
A1, A-1, A01 or A.1. may refer to: Arts and entertainment Film * ''A-1 Headline'', a 2004 Hong Kong film * (English title: ''Our Man in Jamaica''), a 1965 Italian film * ''A1'', a 1999 Syrian film; see List of Syrian films * ''A1'' (2019 film), Indian Tamil film Games * ''A1 – Slave Pits of the Undercity'', a component of '' Scourge of the Slave Lords'' adventure module for ''Dungeons & Dragons'' * Larsen's Opening (ECO code: A01), a chess move * A1, a square on a chessboard Music and dance * A1, a part in contra dance choreography * A-1 Sound Studios, a recording studio owned by Herb Abramson * A-1, an American rap group behind the album '' Mash Confusion'' * A-One (band), a Mandopop group * A1 (group), a British–Norwegian boy band * A1 x J1, a British hip hop duo Albums * ''A1'', an album by Ertuğ Ergin * ''A1'', an album by Tony Cetinski * '' A One'', an album by Ayumi Hamasaki * ''A1'' (album), a 2002 album by the British–Norwegian band A1 Radio * CHIN (A ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Alpha (other)
Alpha ( or ) is the first letter of the Greek alphabet. Alpha or ALPHA may also refer to: Letters * Latin alpha (), a letter of the Latin alphabet * , a glyph in the International Phonetic Alphabet * , a vowel in the General Alphabet of Cameroon Languages * Alfa, the first letter in the NATO phonetic alphabet Art and entertainment Books and comics * ''Alpha'' (Lombard), a Franco-Belgian comics series * '' The Alphas'', a young-adult novel series by Lisi Harrison * ''Alpha 1'' through ''Alpha 9'', anthologies edited by Robert Silverberg Film and television * ''Alpha'' (2018 film), an American prehistoric adventure film * ''Alpha'' (2019 film), a Bangladeshi film * ''Alpha'' (2025 French film), an upcoming French film * '' Alpha Alpha'', a German science fantasy series * '' Alphas'', an American science fiction TV series 2011–2012 * "Alpha" (''The X-Files''), a sixth-season episode of ''The X-Files'' * ''Alpha'' and ''Omega'' (radio plays) * Alpha TV, a Greek televisi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
AMY1A
Alpha-amylase 1 is an enzyme that in humans is encoded by the polich gene In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protei .... This gene is found in many organisms. Amylases are secreted proteins that hydrolyze 1,4-alpha-glucoside bonds in oligosaccharides and polysaccharides, and thus catalyze the first step in digestion of dietary starch and glycogen. The human genome has a cluster of several amylase genes that are expressed at high levels in either salivary gland or pancreas. This gene encodes an amylase isoenzyme produced by the salivary gland. Alternative splicing results in multiple transcript variants encoding the same protein. See also * AMY2A * References External links * * Further reading * * * * * * * * * * * * * * * * * * * * {{enzyme-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
