Adenoviridae
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Adenoviridae
Adenoviruses (members of the family (biology), family ''Adenoviridae'') are medium-sized (90–100 nanometer, nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. Their name derives from their initial isolation from human adenoids in 1953. They have a broad range of vertebrate hosts; in humans, more than 50 distinct adenoviral serotypes have been found to cause a wide range of Adenovirus infection, illnesses, from mild respiratory infections in young children (the common cold) to life-threatening multi-organ disease in people with a Immunodeficiency, weakened immune system. Virology Classification This family contains the following genus, genera: * ''Aviadenovirus'' * ''Barthadenovirus'' * ''Ichtadenovirus'' * ''Mastadenovirus'' (including all human adenoviruses) * ''Siadenovirus'' * ''Testadenovirus'' Diversity In humans, currently there are 88 human adenoviruses (HAdVs) in seven species (H ...
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Mastadenovirus
''Mastadenovirus'' is a genus of viruses in the family ''Adenoviridae''. Humans and other mammals serve as natural hosts. There are 63 species in this genus. The genus as a whole includes many very common causes of human infection, estimated to be responsible for 2 to 5% of all respiratory infections, as well as gastrointestinal and eye infections. Symptoms are usually mild. Canine adenovirus 1 (CAdV-1) can lead to death in puppies, or encephalitis in other carnivore species. Etymology The name ''Mastadenovirus'' is derived from the Greek word ''mastos'' 'breast' (hence ''mammal'') and ''adenovirus'', named for the human adenoids, which the virus was first isolated from. Human serotypes Structure Viruses in ''Mastadenovirus'' are non-enveloped, with icosahedral geometries, and T=25 symmetry. The diameter is around 90 nm. Genomes are linear and non-segmented, around 35-36kb in length. The genome codes for 40 proteins. Life cycle Viral replication is nuclear. Entry i ...
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Barthadenovirus
''Barthadenovirus'' is a genus of viruses, in the family ''Adenoviridae Adenoviruses (members of the family (biology), family ''Adenoviridae'') are medium-sized (90–100 nanometer, nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. ...''. Vertebrates serve as natural hosts. There are 21 species in this genus. From 2002 to 2024, the genus was named ''Atadenovirus''. Taxonomy The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species: * ''Barthadenovirus amazonae'', Psittacine adenovirus 3 * ''Barthadenovirus bosquartum'', Bovine adenovirus 4 * ''Barthadenovirus bosseptimum'', Bovine adenovirus 7 * ''Barthadenovirus bossextum'', Bovine adenovirus 6 * ''Barthadenovirus caerulei'', Psittacine adenovirus 11 * ''Barthadenovirus cervi'', Deer adenovirus 1, also called Odocoileus adenovirus 1 * ''Barthadenovirus draconis'', Bearded ...
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Ichtadenovirus
''Ichtadenovirus'' is a genus of viruses, in the family ''Adenoviridae Adenoviruses (members of the family (biology), family ''Adenoviridae'') are medium-sized (90–100 nanometer, nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. ...''. Fish serve as natural hosts. There is only one species in this genus: White sturgeon adenovirus 1 (''Ichtadenovirus acipenseris''). Structure Viruses in ''Ichtadenovirus'' are non-enveloped, with icosahedral geometries, and T=25 symmetry. The diameter is around 90 nm. Genomes are linear and non-segmented, around 35-36kb in length. The genome codes for 40 proteins. Life cycle Viral replication is nuclear. Entry into the host cell is achieved by attachment of the viral fiber glycoproteins to host receptors, which mediates endocytosis. Replication follows the DNA strand displacement model. DNA-templated transcription, with some alternative splicing mech ...
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Siadenovirus
''Siadenovirus'' is a genus of viruses, in the family ''Adenoviridae Adenoviruses (members of the family (biology), family ''Adenoviridae'') are medium-sized (90–100 nanometer, nm), nonenveloped (without an outer lipid bilayer) viruses with an icosahedral nucleocapsid containing a double-stranded DNA genome. ...''. Vertebrates serve as natural hosts. There are 11 species in this genus. Taxonomy The genus contains the following species, listed by scientific name and followed by the exemplar virus of the species: * ''Siadenovirus carbocapituli'', Great tit adenovirus 3 * ''Siadenovirus cinerei'', Psittacine adenovirus 2 * ''Siadenovirus gallopavotertii'', Turkey adenovirus 3 * ''Siadenovirus paridae'', Great tit adenovirus 1 * ''Siadenovirus ranae'', Frog adenovirus 1 * ''Siadenovirus raptoris'', Raptor adenovirus 1 * ''Siadenovirus sanguineae'', Psittacine adenovirus 7 * ''Siadenovirus spheniscidae'', Chinstrap penguin adenovirus 2 * ''Siadenovirus stercorariidae' ...
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Human Adenovirus 41
Human adenovirus 41 (HAdV-F41), is an enteric adenovirus, a nonenveloped virus with an icosahedral nucleocapsid containing a double-stranded DNA genome. It can particularly target the gastrointestinal tract to cause gastroenteritis, with symptoms similar to rotavirus gastroenteritis and norovirus. It may be present in the gut without causing symptoms and can be detected by using molecular based assays and enzyme immunoassay. As of August 2022, human adenovirus 41 has been identified in a majority of small children with hepatitis of unknown cause in 2 case series. Classification Human adenovirus 41 belongs to the ''Adenoviridae'' family, and along with Human adenovirus 40, is a member of species ''Mastadenovirus faecale''. Pathology It can particularly target the gastrointestinal tract to cause gastroenteritis in very young children. Symptoms appear similar to rotavirus gastroenteritis and norovirus. It may be present in the gut without causing symptoms. In an investig ...
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Nucleocapsid
A capsid is the protein shell of a virus, enclosing its genetic material. It consists of several oligomeric (repeating) structural subunits made of protein called protomers. The observable 3-dimensional morphological subunits, which may or may not correspond to individual proteins, are called capsomeres. The proteins making up the capsid are called capsid proteins or viral coat proteins (VCP). The virus genomic component inside the capsid, along with occasionally present virus core protein, is called the virus core. The capsid and core together are referred to as a nucleocapsid (cf. also virion). Capsids are broadly classified according to their structure. The majority of the viruses have capsids with either helical or icosahedral structure. Some viruses, such as bacteriophages, have developed more complicated structures due to constraints of elasticity and electrostatics. The icosahedral shape, which has 20 equilateral triangular faces, approximates a sphere, while the ...
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Adenovirus Infection
Adenovirus infection is a contagious viral disease, caused by adenoviruses, commonly resulting in a respiratory tract infection. Typical symptoms range from those of a common cold, such as nasal congestion, rhinitis, and cough, to difficulty breathing as in pneumonia. Other general symptoms include fever, fatigue, muscle aches, headache, abdominal pain and swollen neck glands. Onset is usually two to fourteen days after exposure to the virus. A mild eye infection may occur on its own, combined with a sore throat and fever, or as a more severe adenoviral keratoconjunctivitis with a painful red eye, intolerance to light and discharge. Very young children may just have an earache. Adenovirus infection can present as a gastroenteritis with vomiting, diarrhea, and abdominal pain, with or without respiratory symptoms. However, some people have no symptoms. Adenovirus infection in humans are generally caused by '' Adenoviruses'' types B, C, E and F. Spread occurs mainly when ...
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Adenovirus Serotype 36
Human adenovirus 36 (HAdV-36) or Ad-36 or Adv36 is one of 52 types of adenoviruses. It causes respiratory and eye infections in humans. Role in obesity There is a possible positive correlation between body fat and the presence of AD-36 antibodies An antibody (Ab) or immunoglobulin (Ig) is a large, Y-shaped protein belonging to the immunoglobulin superfamily which is used by the immune system to identify and neutralize antigens such as bacteria and viruses, including those that caus ... in the blood. No causal relationship has been established. To date, AD-36 is the only human adenovirus that has been linked with human obesity. See also * Infectoobesity References * {{DEFAULTSORT:Adenovirus Serotype 36 Adenoviridae Medical conditions related to obesity ...
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Common Cold
The common cold, or the cold, is a virus, viral infectious disease of the upper respiratory tract that primarily affects the Respiratory epithelium, respiratory mucosa of the human nose, nose, throat, Paranasal sinuses, sinuses, and larynx. Signs and symptoms may appear in as little as two days after exposure to the virus. These may include coughing, sore throat, rhinorrhea, runny nose, Sneeze, sneezing, headache, fatigue, and fever. People usually recover in seven to ten days, but some symptoms may last up to three weeks. Occasionally, those with other health problems may develop pneumonia. Well over 200 virus strains are implicated in causing the common cold, with rhinoviruses, coronaviruses, Adenoviridae, adenoviruses and enteroviruses being the most common. They spread through the air or indirectly through contact with objects in the environment, followed by transfer to the mouth or nose. Risk factors include going to child care facilities, Sleep deprivation, not sleepin ...
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Adenovirus Serotype 14
Adenovirus serotype 14 (Ad14) is a serovar of adenovirus which, unlike other adenovirus serovars, is known to cause potentially fatal adenovirus infections. According to the United States Centers for Disease Control and Prevention (CDC), as of September 2007, outbreaks have been identified in four states in the U.S., with ten identified deaths since May 2006. Symptoms The virus shows symptoms typical of adenoviral infections. Although these infections are common in humans, they are rarely fatal. Symptoms include: # Common cold, Cold symptoms, such as coughing, sore throat, sneezing, and a runny nose # Pharyngitis # Bronchitis # Diarrhea # Pneumonia # Conjunctivitis # Fever # Cystitis (bladder inflammation) # Rash illness The viral infection presents with symptoms similar to those of other common bacterial infection, bacterial and viral infection, viral infections, such as influenza. Genetics Ad14 is a rare Emerging infectious disease, emerging virus that can cause severe re ...
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Nonenveloped
A viral envelope is the outermost layer of many types of viruses. It protects the genetic material in their life cycle when traveling between host cells. Not all viruses have envelopes. A viral envelope protein or E protein is a protein in the envelope, which may be acquired by the capsid from an infected host cell. Host cell infection process Numerous human pathogenic viruses in circulation are encased in lipid bilayers, and they infect their target cells by causing the viral envelope and cell membrane to fuse. Although there are effective vaccines against some of these viruses, there is no preventative or curative medicine for the majority of them. In most cases, the known vaccines operate by inducing antibodies that prevent the pathogen from entering cells. This happens in the case of enveloped viruses when the antibodies bind to the viral envelope proteins. The membrane fusion event that triggers viral entrance is caused by the viral membrane fusion protein. Many enveloped ...
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Virus
A virus is a submicroscopic infectious agent that replicates only inside the living Cell (biology), cells of an organism. Viruses infect all life forms, from animals and plants to microorganisms, including bacteria and archaea. Viruses are found in almost every ecosystem on Earth and are the most numerous type of biological entity. Since Dmitri Ivanovsky's 1892 article describing a non-bacterial pathogen infecting tobacco plants and the discovery of the tobacco mosaic virus by Martinus Beijerinck in 1898, more than 16,000 of the millions of List of virus species, virus species have been described in detail. The study of viruses is known as virology, a subspeciality of microbiology. When infected, a host cell is often forced to rapidly produce thousands of copies of the original virus. When not inside an infected cell or in the process of infecting a cell, viruses exist in the form of independent viral particles, or ''virions'', consisting of (i) genetic material, i.e., long ...
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