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25-NB (psychedelics)
The 25-NB (25''x''-NB''x'') series, or NBOMe series, also known as the ''N''-benzylphenethylamines, is a family of serotonergic psychedelics. They are substituted phenethylamines and were derived from the 2C (psychedelics), 2C family. The most commonly encountered NBOMe drugs are 25I-NBOMe, 25B-NBOMe, and 25C-NBOMe. The NBOMe drugs act as selective agonists of the serotonin 5-HT2 receptor, 5-HT2 receptors. The 25-NB family is unique relative to other classes of psychedelics in that they are, generally speaking, extremely potency (pharmacology), potent and quite binding selectivity, selective for the 5-HT2 receptors. Use of NBOMe series drugs has caused many deaths and hospitalisations since the drugs popularisation in the 2010s. This is primarily due to their high potency, unpredictable pharmacokinetics, and sellers passing off the compounds in the series as Lysergic acid diethylamide, LSD. Use The 25-NB drugs are inactive oral administration, orally and instead are typically u ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Insufflation
In religious and magical practice, insufflation and exsufflation are ritual acts of blowing, breathing, hissing, or puffing that signify variously expulsion or renunciation of evil or of the devil (the Evil One), or infilling or blessing with good (especially, in religious use, with the Spirit or grace of God). In historical Christian practice, such blowing appears most prominently in the liturgy, and is connected almost exclusively with baptism and other ceremonies of Christian initiation, achieving its greatest popularity during periods in which such ceremonies were given a prophylactic or exorcistic significance, and were viewed as essential to the defeat of the devil or to the removal of the taint of original sin. Ritual blowing occurs in the liturgies of catechumenate and baptism from a very early period and survives into the modern Roman Catholic, Greek Orthodox, Maronite, and Coptic rites. Catholic liturgy post-Vatican II (the so-called ''novus ordo'' 1969) has la ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Clinical Toxicology
''Clinical Toxicology'' (until 2005, ''Journal of Toxicology: Clinical Toxicology'') is a peer-reviewed medical journal of clinical toxicology. It is published by Taylor and Francis and is the official journal of the American Academy of Clinical Toxicology, the European Association of Poisons Centres and Clinical Toxicologists, the American Association of Poison Control Centers and the Asia Pacific Association of Medical Toxicology. The editor-in-chief is Steven A. Seifert ( University of New Mexico). The journal is published in 12 issues per year in simultaneous print and online editions. According to the ''Journal Citation Reports'', its 2020 Impact Factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... is 4.467, ranking it 24th out of 93 journals by Impact Factor in the g ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bioavailability
In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. By definition, when a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered via routes other than intravenous, its bioavailability is lower due to intestinal epithelium absorption and first-pass metabolism. Thereby, mathematically, bioavailability equals the ratio of comparing the area under the plasma drug concentration curve versus time (AUC) for the extravascular formulation to the AUC for the intravascular formulation. AUC is used because AUC is proportional to the dose that has entered the systemic circulation. Bioavailability of a drug is an average value; to take population variability into account, deviation range is shown as ±. To ensure that the drug taker who has poor absorption is dosed appropriately, the bottom value of the deviation range is employed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Smoking
Smoking is a practice in which a substance is combusted, and the resulting smoke is typically inhaled to be tasted and absorbed into the bloodstream of a person. Most commonly, the substance used is the dried leaves of the tobacco plant, which have been rolled with a small rectangle of paper into an elongated cylinder called a cigarette. Other forms of smoking include the use of a smoking pipe or a bong. Smoking is primarily practised as a route of administration for psychoactive chemicals because the active substances within the burnt dried plant leaves vaporize and can be airborne-delivered into the respiratory tract, where they are rapidly absorbed into the bloodstream of the lungs and then reach the central nervous system. In the case of tobacco smoking, these active substances are a mixture of aerosol particles that includes the pharmacologically active alkaloid nicotine, which stimulates the nicotinic acetylcholine receptors in the brain. Other notable active ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25T7-NBOMe
25T7-NBOMe (also known as 2C-T-7-NBOMe or NBOMe-2C-T-7) is a substituted phenethylamine derivative from the 25-NB family. It acts as an agonist at the 5-HT2A and 5-HT2C serotonin receptors, has psychedelic effects and has been sold as a designer drug. See also * 2C-T-7 2C-T-7, also known as 4-propylthio-2,5-dimethoxyphenethylamine, is a psychedelic phenethylamine of the 2C family. In his book '' PiHKAL: A Chemical Love Story'', Alexander Shulgin lists the dosage range as 10–30 mg. 2C-T-7 is generall ... * 25T2-NBOMe * 25T4-NBOMe * 25E-NBOH * 25P-NBOMe References External links 25T7-NBOMe - Isomer Design 25-NB (psychedelics) 5-HT2A agonists 5-HT2C agonists Psychedelic phenethylamines Thioethers {{pharm-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25T4-NBOMe
25T4-NBOMe is a serotonergic psychedelic of the 25-NB (NBOMe) family. It is the NBOMe analogue of 2C-T-4. The drug acts as a highly potent and selective agonist of the serotonin 5-HT2 receptors. Its reported active dose range has been described as 150 to 1,200μg, with a typical dose estimate of 500μg. 25T4-NBOMe was first described in the scientific literature by at least 2012. See also * 25T2-NBOMe * 25T7-NBOMe 25T7-NBOMe (also known as 2C-T-7-NBOMe or NBOMe-2C-T-7) is a substituted phenethylamine derivative from the 25-NB family. It acts as an agonist at the 5-HT2A and 5-HT2C serotonin receptors, has psychedelic effects and has been sold as a desig ... References External links 25T4-NBOMe - Isomer DesignThe Small & Handy 25T4-NBOMe Thread - Bluelight 5-HT2A agonists 5-HT2B agonists 25-NB (psychedelics) Psychedelic phenethylamines Thioethers Isopropyl compounds Methoxy compounds Secondary amines {{Hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25T2-NBOMe
25T2-NBOMe is a serotonergic psychedelic of the 25-NB (NBOMe) family. It is the NBOMe analogue of 2C-T-2. The drug acts as a highly potent and selective agonist of the serotonin 5-HT2 receptors. Its reported active dose range has been described as 100 to 1,000μg, with a typical dose estimate of 500μg. 25T2-NBOMe was first described in the scientific literature by at least 2012.Casale, J. F., & Hays, P. A. (2012). Characterization of eleven 2, 5-dimethoxy-N-(2-methoxybenzyl) phenethylamine (NBOMe) derivatives and differentiation from their 3-and 4-methoxybenzyl analogues—part I. ''Microgram Journal'', ''9''(2), 84–109. https://www.dea.gov/sites/default/files/pr/microgram-journals/2012/mj9_84-109.pdf See also * 25T4-NBOMe * 25T7-NBOMe 25T7-NBOMe (also known as 2C-T-7-NBOMe or NBOMe-2C-T-7) is a substituted phenethylamine derivative from the 25-NB family. It acts as an agonist at the 5-HT2A and 5-HT2C serotonin receptors, has psychedelic effects and has been sold a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25P-NBOMe
25P-NBOMe (2C-P-NBOMe, NBOMe-2C-P) is a derivative of the phenethylamine 2C-P. It acts in a similar manner to related compounds such as 25I-NBOMe, which are potent agonists at the 5-HT2A receptor Receptor may refer to: * Sensory receptor, in physiology, any neurite structure that, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and respond .... 25P-NBOMe has been sold as a drug and produces similar effects in humans to related compounds such as 25I-NBOMe and 25C-NBOMe. Society and culture Legal status United Kingdom See also * 25-NB References External links 25P-NBOMe - Isomer Design 25-NB (psychedelics) Designer drugs {{hallucinogen-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25N-NBOMe
25N-NBOMe, also known as 2C-N-NBOMe or NBOMe-2C-N, is a derivative of the hallucinogen 2C-N. The pharmacological properties of 25N-NBOMe have not been described in the scientific literature, but it is believed to act in a similar manner to related compounds such as 25I-NBOMe and 25C-NBOMe, which are potent agonists at the 5HT2A receptor. 25N-NBOMe has been sold as a street drug and has only been described in the literature in terms of identification by forensic analysis. Interactions Toxicity and harm potential Neurotoxic and cardiotoxic actions Emergency treatment Pharmacology Pharmacodynamics 25N-NBOMe is a selective and highly potent agonist of the serotonin 5-HT2 receptors. Its affinities (Ki) are 0.144nM at the serotonin 5-HT2A receptor, 8.7nM at the serotonin 5-HT2B receptor, and 1.06nM at the serotonin 5-HT2C receptor. In terms of affinity, the drug has approximately 7.4-fold selectivity for the serotonin 5-HT2A receptor over the serotonin 5-HT2C receptor a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25H-NBOMe
25H-NBOMe, also known as NBOMe-2C-H, is a derivative of the phenethylamine hallucinogen 2C-H, which acts as a highly potent full agonist for the human 5-HT2A receptor. Interactions Toxicity and harm potential Neurotoxic and cardiotoxic actions Emergency treatment Pharmacology 25H-NBOMe acts as an agonist of the serotonin 5-HT2 receptors. In accordance with its psychedelic effects in humans, it produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. The drug has also been found to produce antidepressant-like effects in rodents. 25H-NBOMe has shown reinforcing effects in rodents. This included conditioned place preference (CPP) and self-administration Self-administration is, in its Medicine, medical sense, the process of a subject administering a Pharmacology, pharmacological substance to themself. A clinical example of this is the subcutaneous "self-injection" of insulin by a Diabetes, diabetic .... Society and culture Legal status ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
25E-NBOMe
25E-NBOMe, also known as 2C-E-NBOMe or NBOMe-2C-E, is a derivative of the phenethylamine 2C-E. It acts in a similar manner to related compounds such as 25I-NBOMe, which are potent agonists at the 5-HT2A receptor. 25E-NBOMe has been sold as a drug and produces similar effects in humans to related compounds such as 25I-NBOMe and 25C-NBOMe. Interactions Toxicity and harm potential Neurotoxic and cardiotoxic actions Emergency treatment Pharmacology Pharmacodynamics 25E-NBOMe acts as an agonist of the serotonin 5-HT2 receptors. In accordance with its psychedelic effects in humans, it produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents. 25E-NBOMe has shown reinforcing effects in rodents. This included conditioned place preference (CPP) and self-administration. The reinforcing effects of 25E-NBOMe were mediated by increased dopaminergic signaling in the nucleus accumbens. Blockade of the dopamine Dopamine (DA, a contraction of 3 ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
