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Biogenesis Of Lysosome-related Organelles Complex 3
BLOC-3 or biogenesis of lysosome-related organelles complex 3 is a ubiquitously expressed multisubunit protein complex. Interactions biogenesis of lysosome-related organelles complex 3 has been shown to interact with Rab9A. Complex Components The identified protein subunits of BLOC-1 include: * HPS1 Hermansky–Pudlak syndrome 1 protein is a protein that in humans is encoded by the ''HPS1'' gene. This gene encodes a protein that may play a role in organelle In cell biology, an organelle is a specialized subunit, usually within a cell, th ..., * HPS4 References Cell biology {{cell-biology-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, responding to stimuli, providing structure to cells and organisms, and transporting molecules from one location to another. Proteins differ from one another primarily in their sequence of amino acids, which is dictated by the nucleotide sequence of their genes, and which usually results in protein folding into a specific 3D structure that determines its activity. A linear chain of amino acid residues is called a polypeptide. A protein contains at least one long polypeptide. Short polypeptides, containing less than 20–30 residues, are rarely considered to be proteins and are commonly called peptides. The individual amino acid residues are bonded together by peptide bonds and adjacent amino acid residues. The sequence of amino acid resid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rab9A
Ras-related protein Rab-9A is a protein that in humans is encoded by the ''RAB9A'' gene. Interactions RAB9A has been shown to interact with RABEPK, TIP47 Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the ''M6PRBP1'' gene. Its gene product, as well as the gene itself, is commonly known as TIP47. Function Mannose 6-phosphate receptors (MPRs) ... and the Biogenesis of lysosome-related organelles complex 3. References Further reading * * * * * * * * * * * * * * * * {{Gene-X-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HPS1
Hermansky–Pudlak syndrome 1 protein is a protein that in humans is encoded by the ''HPS1'' gene. This gene encodes a protein that may play a role in organelle In cell biology, an organelle is a specialized subunit, usually within a cell, that has a specific function. The name ''organelle'' comes from the idea that these structures are parts of cells, as organs are to the body, hence ''organelle,'' the ... biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is a component of three different protein complexes termed biogenesis of lysosome-related organelles complex (BLOC)-3, BLOC4, and BLOC5. Mutations in this gene are associated with Hermansky–Pudlak syndrome type 1. Multiple transcript variants encoding distinct isoforms have been identified for this gene; the full-length sequences of some of these have not been determined yet. References External links GeneReviews/NCBI/NIH/UW entry on Hermansky–Pudlak syndrome Furthe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
HPS4
Hermansky–Pudlak syndrome 4 protein is a protein that in humans is encoded by the ''HPS4'' gene. Hermansky–Pudlak syndrome is a disorder of organelle biogenesis in which oculocutaneous albinism, bleeding, and pulmonary fibrosis result from defects of melanosomes, platelet dense granules, and lysosomes. Mutations in this gene as well as several others can cause this syndrome. The protein encoded by this gene appears to be important in organelle biogenesis and is similar to the mouse 'light ear' protein. Five transcript variants encoding different isoforms have been found for this gene. In addition, transcript variants utilizing alternative polyadenylation signals exist. In melanocytic cells HPS4 gene expression may be regulated by MITF Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the ''MITF'' gene. MITF is a basic helix-loop-helix leucine zipper transcription fact ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
