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Bengt Mannervik
Bengt Mannervik (born 19 August 1943 in Stockholm), is a Swedish biochemist known especially for work on enzymes related to glutathione metabolism. Education After secondary education under his birth name, Bengt Eriksson, at Norra Real in Stockholm, Bengt Mannervik studied at Stockholm University where he obtained his Licentiate of Philosophy in chemistry with a thesis on biochemistry in 1967. He obtained a Ph.D. there in 1969, and became a Docent (associate professor) at Stockholm University in 1970. Career Bengt Mannervik was Senior Lecturer in the Department of Biochemistry at Stockholm University from 1970 to 1987, and was Acting Chairman for numerous periods between 1971 and 1988. In 1988 he moved to Uppsala University as holder of the Karin and Herbert Jacobsson endowed chair in biochemistry. He was Chairman of the Biochemistry Department from 1998 to 2000. From 2010 to 2012 he was a Senior Professor at Uppsala University, and was a member of the university senate fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Stockholm
Stockholm (; ) is the Capital city, capital and List of urban areas in Sweden by population, most populous city of Sweden, as well as the List of urban areas in the Nordic countries, largest urban area in the Nordic countries. Approximately 1 million people live in the Stockholm Municipality, municipality, with 1.6 million in the Stockholm urban area, urban area, and 2.5 million in the Metropolitan Stockholm, metropolitan area. The city stretches across fourteen islands where Mälaren, Lake Mälaren flows into the Baltic Sea. Outside the city to the east, and along the coast, is the island chain of the Stockholm archipelago. The area has been settled since the Stone Age, in the 6th millennium BC, and was founded as a city in 1252 by Swedish statesman Birger Jarl. The city serves as the county seat of Stockholm County. Stockholm is the cultural, media, political, and economic centre of Sweden. The Stockholm region alone accounts for over a third of the country's Gros ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Protein Engineering Design And Selection
''Protein Engineering, Design & Selection'' (PEDS) is a publication of Oxford University Press. PEDS publishes research papers and review articles that are relevant to the engineering, design and selection of proteins with novel or improved properties for practical applications, or aimed at understanding the fundamental links between protein sequence, structure, dynamics, function, and evolution. History Originally titled ''Protein Engineering'' and published by IRL Press Ltd, the journal was founded in 1986 under executive editors Anthony R. Rees and Gregory A. Petsko. Later senior editors included Sir Alan R. Fersht, Valerie D. Daggett, Sir Gregory Winter, and Roberto A. Chica. Abstracting and indexing ''Protein Engineering, Design & Selection'' is indexed in Biological Abstracts, BIOSIS Previews, Biotechnology and Bioengineering Abstracts, Biotechnology Citation Index, CAB Abstracts, Chemical Abstracts, Current Contents, EMBASE, Environmental Science and Pollution ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Detoxication
Detoxification or detoxication (detox for short) is the physiological or medicinal removal of toxic substances from a living organism, including the human body, which is mainly carried out by the liver. Additionally, it can refer to the period of drug withdrawal during which an organism returns to homeostasis after long-term use of an addictive substance. In medicine, detoxification can be achieved by decontamination of poison ingestion and the use of antidotes as well as techniques such as dialysis and (in a limited number of cases) chelation therapy. Many alternative medicine practitioners promote various types of detoxification such as detoxification diets. Sense about Science, a UK-based charitable trust, determined that most such dietary "detox" claims lack any supporting evidence. The liver and kidney are naturally capable of detox, as are intracellular (specifically, inner membrane of mitochondria or in the endoplasmic reticulum of cells) proteins such as CYP enzymes. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Malaria
Malaria is a Mosquito-borne disease, mosquito-borne infectious disease that affects vertebrates and ''Anopheles'' mosquitoes. Human malaria causes Signs and symptoms, symptoms that typically include fever, Fatigue (medical), fatigue, vomiting, and headaches. In severe cases, it can cause jaundice, Epileptic seizure, seizures, coma, or death. Symptoms usually begin 10 to 15 days after being bitten by an infected ''Anopheles'' mosquito. If not properly treated, people may have recurrences of the disease months later. In those who have recently survived an infection, reinfection usually causes milder symptoms. This partial Immunity (medical), resistance disappears over months to years if the person has no continuing exposure to malaria. The mosquitoes themselves are harmed by malaria, causing reduced lifespans in those infected by it. Malaria is caused by protozoa, single-celled microorganisms of the genus ''Plasmodium''. It is spread exclusively through bites of infected female ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mosquitoes
Mosquitoes, the Culicidae, are a family of small flies consisting of 3,600 species. The word ''mosquito'' (formed by '' mosca'' and diminutive ''-ito'') is Spanish and Portuguese for ''little fly''. Mosquitoes have a slender segmented body, one pair of wings, three pairs of long hair-like legs, and specialized, highly elongated, piercing-sucking mouthparts. All mosquitoes drink nectar from flowers; females of some species have in addition adapted to drink blood. The group diversified during the Cretaceous period. Evolutionary biologists view mosquitoes as micropredators, small animals that parasitise larger ones by drinking their blood without immediately killing them. Medical parasitologists view mosquitoes instead as vectors of disease, carrying protozoan parasites or bacterial or viral pathogens from one host to another. The mosquito life cycle consists of four stages: egg, larva, pupa, and adult. Eggs are laid on the water surface; they hatch into motile larv ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ecdysone
Ecdysone is a prohormone of the major insect molting hormone 20-hydroxyecdysone, secreted from the prothoracic glands. It is of steroidal structure. Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids. Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In ''Drosophila melanogaster'', an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires. It causes chromosome puffs (sites of high expression) to form in polytene chromosomes. Recent findings in the laboratory of Chris Q. Doe have found a novel role of this hormone in regulating temporal gene transitions within neural stem cells of the fruit fly. Ecdysone and other ecdysteroids also appear in many plants mostly as a protection agent ( toxins or antifeedants) against herbivorous insects. These phytoecdysteroids have been reputed to have medicinal value. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Glutathione Transferase
Glutathione ''S''-transferases (GSTs), previously known as ligandins, are a family of eukaryotic and prokaryotic phase II metabolic isozymes best known for their ability to catalyze the conjugation of the reduced form of glutathione (GSH) to xenobiotic substrates for the purpose of detoxification. The GST family consists of three superfamilies: the cytosolic, mitochondrial, and microsomal—also known as MAPEG—proteins. Members of the GST superfamily are extremely diverse in amino acid sequence, and a large fraction of the sequences deposited in public databases are of unknown function. The Enzyme Function Initiative (EFI) is using GSTs as a model superfamily to identify new GST functions. GSTs can constitute up to 10% of cytosolic protein in some mammalian organs. GSTs catalyse the conjugation of GSH—via a sulfhydryl group—to electrophilic centers on a wide variety of substrates in order to make the compounds more water-soluble. This activity detoxifies endogenous c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Rochester Hills
Rochester Hills is a city in Oakland County, Michigan, United States. A northern suburb of Detroit, Rochester Hills is located about north of downtown Detroit. As of the 2020 census, the city had a population of 76,300. The area was first settled by European Americans in 1817, and organized as Avon Township in 1835. The City of Rochester incorporated in 1967, while the remaining area of Avon Township was incorporated and renamed the City of Rochester Hills in 1984. Considered a northern suburb of Metro Detroit, Rochester Hills is about north of Detroit. History Prior to European settlement, the area now known as Rochester Hills was inhabited by Native Americans, namely the Potawatomi. The Potawatomi depended on the area's abundant water sources, such as the Clinton River and Paint Creek, to grow crops, fish, and travel. They resided here until the 1807 Treaty of Detroit caused them, along with the Odawa, Wyandot, and Ojibwe peoples, to cede their land in Southeast Michigan. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Maxygen
Maxygen Inc. was a biopharmaceutical company focused on developing improved versions of protein drugs using DNA shuffling and other protein modification technologies. The company was headquartered in Redwood City, CA. It dissolved in 2013. The Maxygen legacy was revived in 2018 with a focus on Directed Evolution of Proteins using Molecular Breeding. Maxygen LLC is currently headquartered in Sunnyvale, CA. Clinical Programs Maxygen Inc's clinical programs included a novel G-CSF for the treatment of chemotherapy-induced neutropenia, which entered clinical trials in 2006. Maxygen also had a preclinical program, MAXY-4, to develop a novel CTLA4-Ig therapeutic for the treatment of rheumatoid arthritis and other autoimmune diseases. Technologies Maxygen Inc. was established to commercially exploit its proprietary recombination-based technologies for creating genetic diversity, known as its Molecular Breeding directed evolution platform. These technologies allow the generation of ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Swedish Orphan Biovitrum
Swedish Orphan Biovitrum AB is an international biopharmaceutical company dedicated to treatments in the areas of haematology, immunology and specialty care, based in Stockholm, Sweden. In 2020 it had a revenue of SEK 15.261 billion and 1,509 employees. History Sobi traces its origins to a subsidiary of Kärnbolaget Aktiebolag Biokemisk Industri in the 1930s, which changed its name to in 1951 and merged with to become KabiVitrum in the 1970s. Sobi has been involved in the process development and manufacturing of recombinant protein drugs since the technology was first developed around 30 years ago, then as part of KabiVitrum. Biovitrum was formed in 2001 through the merger of several units of Pharmacia (now Pfizer) and spun off to a consortium of investors led by Nordic Capital and MPM Capital Funds. Operations included a research unit focused on metabolic diseases, a process development unit for protein drugs and a plasma product operation. In 2002 Sobi sold its plasma ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chemtura
Chemtura Corporation was a global corporation headquartered in Philadelphia, Pennsylvania, United States, with its other principal executive office in Middlebury, Connecticut. Merged into Lanxess in 2017, the company focused on specialty chemicals for various industrial sectors, and these were transportation (including automotive), energy, and electronics. Chemtura operated manufacturing plants in 11 countries. Its primary markets were industrial manufacturing customers. The corporation employed approximately 2500 people for research, manufacturing, logistics, sales and administration. Operations were located in North America, Latin America, Europe and Asia. In addition, the company had significant joint ventures primarily in the United States. For the year ended December 31, 2015, the company's global core segment revenue was $1.61 billion. Chief executive officer was Craig A. Rogerson, who was also the president and chairman of the board of Chemtura Corporation. On April 21, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
