 |
Base Excision Repair
Base excision repair (BER) is a cellular mechanism, studied in the fields of biochemistry and genetics, that repairs damaged DNA throughout the cell cycle. It is responsible primarily for removing small, non-helix-distorting base lesions from the genome. The related nucleotide excision repair pathway repairs bulky helix-distorting lesions. BER is important for removing damaged bases that could otherwise cause mutations by mispairing or lead to breaks in DNA during replication. BER is initiated by DNA glycosylases, which recognize and remove specific damaged or inappropriate bases, forming AP sites. These are then cleaved by an AP endonuclease. The resulting single-strand break can then be processed by either short-patch (where a single nucleotide is replaced) or long-patch BER (where 2–10 new nucleotides are synthesized). Lesions processed by BER Single bases in DNA can be chemically damaged by a variety of mechanisms, the most common ones being deamination, oxidation, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |
|
BER Basic Pathway
BER may refer to: Science and technology Biology and medicine * Basal electrical rhythm, spontaneous rhythmic slow action potentials that some smooth muscles of the GI tract display * Base excision repair, a DNA repair pathway * Benign early repolarization, a heart arrhythmia * Blossom end rot, a plant disorder Computing * Basic Encoding Rules, a set of rules for encoding data * Bit error rate, the ratio between the number of incorrect bits transmitted to the total Places * Bermuda (IOC and UNDP code), a British overseas territory * Bohai Economic Rim, the economic region surrounding Tianjin, China Transport * Air Berlin (ICAO code: BER), a defunct German airline * Berlin Brandenburg Airport (IATA code: BER), Germany * Berlin station (Connecticut) (Amtrak code: BER), United States Other uses * Beyond economic repair, a rating of a damaged item * Block Exemption Regulation, published by the European Commission regarding European Union competition law * Building the Education Revol ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] [Amazon] |