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BRCA PARP Twohit
Brca or BRCA may refer to: * Brca (Bar Municipality), a village in Macedonia * ''BRCA'' mutation, mutations in two genes which produce a hereditary breast-ovarian cancer syndrome **''BRCA1'', the first of these genes to be discovered **''BRCA2 ''BRCA2'' and BRCA2 () are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associate ...'', the second of these genes to be discovered * British Radio Car Association, a British radio controlled car racing organisation * Brotherhood Railway Carmen of America, a defunct American trade union * Bureau Central de Renseignements et d'Action, the Free French intelligence agency during World War II {{disambiguation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brca (Bar Municipality)
Brca () is a village in the municipality of Bar, Montenegro , image_flag = Flag of Montenegro.svg , image_coat = Coat of arms of Montenegro.svg , coa_size = 80 , national_motto = , national_anthem = () , image_map = Europe-Mont .... This village is famous for Ratac Abbey and the Villa Brca, places known to many in Montenegro and the Bar Municipality. Demographics According to the 2015 census, its population was 278. References Populated places in Bar Municipality {{Montenegro-geo-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BRCA Mutation
A ''BRCA'' mutation is a mutation in either of the ''BRCA1'' and ''BRCA2'' genes, which are tumour suppressor genes. Hundreds of different types of mutations in these genes have been identified, some of which have been determined to be harmful, while others have no proven impact. Harmful mutations in these genes may produce a hereditary breast–ovarian cancer syndrome in affected persons. Only 5–10% of breast cancer cases in women are attributed to ''BRCA1'' and ''BRCA2'' mutations (with ''BRCA1'' mutations being slightly more common than ''BRCA2'' mutations), but the impact on women with the gene mutation is more profound. Women with harmful mutations in either ''BRCA1'' or ''BRCA2'' have a risk of breast cancer that is about five times the normal risk, and a risk of ovarian cancer that is about ten to thirty times normal. The risk of breast and ovarian cancer is higher for women with a high-risk ''BRCA1'' mutation than with a ''BRCA2'' mutation. Having a high-risk mutation ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the ''BRCA1'' () gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. ''BRCA1'' is a human tumor suppressor gene (also known as a caretaker gene) and is responsible for repairing DNA. ''BRCA1'' and ''BRCA2'' are unrelated proteins, but both are normally expressed in the cells of breast and other tissues, where they help repair damaged DNA, or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosomal damage with an important role in the error-free repair of DNA double-strand breaks. If ''BRCA1'' or ''BRCA2'' itself is damaged by a BRCA mutation, damaged DNA is not repaired properly, and this increases the risk for breast cancer. ''BRCA1'' and ''BRCA2'' have been described as "breast cancer susceptibility genes" and "breast cancer susceptibility proteins". The predominant allele has a no ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
BRCA2
''BRCA2'' and BRCA2 () are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are gene nomenclature, maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes its association with the FANC proteins, FANC protein complex. Orthologs, styled ''Brca2'' and Brca2, are common in other vertebrate species. May 2021 ''BRCA2'' is a human tumor suppressor gene (specifically, a caretaker gene), found in all humans; its protein, also called by the synonym breast cancer type 2 susceptibility protein, is responsible for repairing DNA. ''BRCA2'' and ''BRCA1'' are normally expressed in the cells of breast and other tissue, where they help repair damaged DNA or destroy cells if DNA cannot be repaired. They are involved in the repair of chromosome, chromosomal damage with an important role in th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
British Radio Car Association
The British Radio Car Association (or BRCA) is an organisation that promotes the construction and racing of all types of radio controlled cars in the United Kingdom. Founded in 1971 by Ted Longshaw and Keith Plested, who was also the founder of PB Racing, a manufacturer of RC cars; they coordinate BRCA affiliated clubs in the UK, and offer insurance for any accidents that might occur. They also organise regional and national racing events for various classes. Each year the BRCA produces a rules booklet for every UK racing class, such as 1:10 Electric touring cars, 1:8 Nitro circuit cars and 1:16 Electric micro offroad cars with specific rules as regard to maximum and minimum dimensions, and homologated motors and cells. It is recommended (and at some clubs compulsory) to become a BRCA member due to its insurance and health and safety benefits. The BRCA is a member of the European Federation of Radio Operated Model Automobiles (EFRA). The BRCA is also affiliated with the Mo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Brotherhood Railway Carmen Of America
The Brotherhood Railway Carmen of America, commonly known as the Brotherhood of Railway Carmen (BRC), was a fraternal benefit society and trade union established in the United States of America. The BRC united railroad employees involved in the repair and inspection of railroad cars to advance their common interests in the realm of hours of work, wages, and working conditions. The organization traces its genesis to a seven-member group called the Brotherhood of Railway Car Repairers of North America founded late in October 1888 in a railway car in Iowa. This group merged with a rival organization, the Carmen's Mutual Aid Association at a "Joint Convention" held in Topeka, Kansas in September 1890, formally establishing the organization and its bylaws and electing its officers under the new permanent name. The BRC was disestablished through merger into the Transportation Communications International Union (TCU) in 1986, which was in turn amalgamated into the International Associati ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
