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BCM Theory
Bienenstock–Cooper–Munro (BCM) theory, BCM synaptic modification, or the BCM rule, named after Elie Bienenstock, Leon Cooper, and Paul Munro, is a physical theory of learning in the visual cortex developed in 1981. The BCM model proposes a sliding threshold for long-term potentiation (LTP) or long-term depression (LTD) induction, and states that synaptic plasticity is stabilized by a dynamic adaptation of the time-averaged postsynaptic activity. According to the BCM model, when a pre-synaptic neuron fires, the post-synaptic neurons will tend to undergo LTP if it is in a high-activity state (e.g., is firing at high frequency, and/or has high internal calcium concentrations), or LTD if it is in a lower-activity state (e.g., firing in low frequency, low internal calcium concentrations). This theory is often used to explain how cortical neurons can undergo both LTP or LTD depending on different conditioning stimulus protocols applied to pre-synaptic neurons (usually high-frequency s ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Elie Bienenstock
Elie may refer to: People * Elie (given name) * Elie (surname) Places *Elie, Fife, a village in Scotland, now part of the town of Elie and Earlsferry *Elie, Manitoba, Canada **Elie, Manitoba tornado See also *Elie Hall, Grenada *Elie House, country house in Elie, Fife, Scotland * *Eli (other) *Elia (other) *Élie, the French equivalent of "Elias" or "Elijah" *Ellie (other) *Ely (surname) {{disambiguation, given name, surname ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Synaptic Plasticity
In neuroscience, synaptic plasticity is the ability of synapses to Chemical synapse#Synaptic strength, strengthen or weaken over time, in response to increases or decreases in their activity. Since memory, memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (''see Hebbian theory''). Plastic change often results from the alteration of the number of neurotransmitter receptors located on a synapse. There are several underlying mechanisms that cooperate to achieve synaptic plasticity, including changes in the quantity of neurotransmitters released into a synapse and changes in how effectively cells respond to those neurotransmitters. Synaptic plasticity in both Excitatory synapse, excitatory and Inhibitory synapse, inhibitory synapses has been found to be dependent upon postsynaptic calcium release. Historical discoveries In 1973, Terje Lømo and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Biophysics
Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics, developmental biology and systems biology. The term ''biophysics'' was originally introduced by Karl Pearson in 1892. Roland Glaser. Biophysics: An Introduction'. Springer; 23 April 2012. . The term ''biophysics'' is also regularly used in academia to indicate the study of the physical quantities (e.g. electric current, temperature, stress, entropy) in biological systems. Other biological sciences also perform research on the biophysical properties of living organisms including molecular biology, cell biology, chemical biology, and bioche ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Parallel Distributed Processing
Connectionism is an approach to the study of human mental processes and cognition that utilizes mathematical models known as connectionist networks or artificial neural networks. Connectionism has had many "waves" since its beginnings. The first wave appeared 1943 with Warren Sturgis McCulloch and Walter Pitts both focusing on comprehending neural circuitry through a formal and mathematical approach, and Frank Rosenblatt who published the 1958 paper "The Perceptron: A Probabilistic Model For Information Storage and Organization in the Brain" in ''Psychological Review'', while working at the Cornell Aeronautical Laboratory. The first wave ended with the 1969 book about the limitations of the original perceptron idea, written by Marvin Minsky and Seymour Papert, which contributed to discouraging major funding agencies in the US from investing in connectionist research. With a few noteworthy deviations, most connectionist research entered a period of inactivity until the mid-1980s. Th ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Monocular Deprivation
Monocular deprivation is an experimental technique used by neuroscientists to study central nervous system plasticity. Generally, one of an animal's eyes is sutured shut during a period of high cortical plasticity (4–5 weeks-old in mice (Gordon 1997)). This manipulation serves as an animal model for amblyopia, a permanent deficit in visual sensation not due to abnormalities in the eye (which occurs, for example, in children who grow up with cataracts - even after cataract removal, they do not see as well as others). Background David Hubel and Torsten Wiesel (who won the Nobel Prize in Physiology for their elucidation of receptive field properties of cells in primary visual cortex) first performed the technique in felines. Kittens, although less-closely related evolutionarily to humans even than rodents, have a remarkably similar visual system to humans. They found that ocular dominance columns (the orderly clustering of V1 neurons representing visual input from one or both eye ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nature (journal)
''Nature'' is a British weekly scientific journal founded and based in London, England. As a multidisciplinary publication, ''Nature'' features Peer review, peer-reviewed research from a variety of academic disciplines, mainly in science and technology. It has core editorial offices across the United States, continental Europe, and Asia under the international scientific publishing company Springer Nature. ''Nature'' was one of the world's most cited scientific journals by the Science Edition of the 2022 ''Journal Citation Reports'' (with an ascribed impact factor of 50.5), making it one of the world's most-read and most prestigious academic journals. , it claimed an online readership of about three million unique readers per month. Founded in the autumn of 1869, ''Nature'' was first circulated by Norman Lockyer and Alexander MacMillan (publisher), Alexander MacMillan as a public forum for scientific innovations. The mid-20th century facilitated an editorial expansion for the j ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Serena Dudek
Serena M. Dudek (born 1964; Anaheim, California), is an American neuroscientist known for her work on long-term depression and synaptic plasticity in the CA2 region of the hippocampus. Early life and education Dudek's father was an English professor at Fullerton College, and her mother was a clinical cytologist and medical technologist. In high school, she worked at Knott's Berry Farm, selling ice cream and popcorn. She was also on the drill team at Savanna High School. In 1982, Serena Dudek matriculated into the University of California, Irvine. Dudek worked as an undergraduate researcher in the lab of Gary Lynch, studying the degradation of brain spectrin, also known as fodrin, by calpains. Serena Dudek enrolled a Ph.D. program at Brown University where she joined Mark Bear's lab to study long-term depression in a collaboration with Leon Cooper. Her work was used to support the BCM theory. She finished her Ph.D. studies in 1992. Career After receiving her doctorate, D ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Long-term Depression
In neurophysiology, long-term depression (LTD) is an activity-dependent reduction in the efficacy of neuronal synapses lasting hours or longer following a long patterned stimulus. LTD occurs in many areas of the Central Nervous System, CNS with varying mechanisms depending upon brain region and developmental progress. As the opposing process to long-term potentiation (LTP), LTD is one of several processes that serves to selectively weaken specific synapses in order to make constructive use of synaptic strengthening caused by LTP. This is necessary because, if allowed to continue increasing in strength, synapses would ultimately reach a ceiling level of efficiency, which would inhibit the encoding of new information. Both LTD and LTP are forms of synaptic plasticity. Characterisation LTD in the hippocampus and cerebellum have been the best characterized, but there are other brain areas in which mechanisms of LTD are understood. LTD has also been found to occur in different type ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Long-term Potentiation
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons. The opposite of LTP is long-term depression, which produces a long-lasting decrease in synaptic strength. It is one of several phenomena underlying synaptic plasticity, the ability of chemical synapses to change their strength. As memories are thought to be encoded by modification of synaptic strength, LTP is widely considered one of the major cellular mechanisms that underlies learning and memory. LTP was discovered in the rabbit hippocampus by Terje Lømo in 1966 and has remained a popular subject of research since. Many modern LTP studies seek to better understand its basic biology, while others aim to draw a causal link between LTP and behavioral learning. Still, others try to develop methods, pharmacologic or otherwise, of enhanci ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Normalisable Wave Function
In quantum physics, a wave function (or wavefunction) is a mathematical description of the quantum state of an isolated quantum system. The most common symbols for a wave function are the Greek letters and (lower-case and capital psi, respectively). Wave functions are complex-valued. For example, a wave function might assign a complex number to each point in a region of space. The Born rule provides the means to turn these complex probability amplitudes into actual probabilities. In one common form, it says that the squared modulus of a wave function that depends upon position is the probability density of measuring a particle as being at a given place. The integral of a wavefunction's squared modulus over all the system's degrees of freedom must be equal to 1, a condition called ''normalization''. Since the wave function is complex-valued, only its relative phase and relative magnitude can be measured; its value does not, in isolation, tell anything about the magnitudes or d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Purkinje Cell
Purkinje cells or Purkinje neurons, named for Czech physiologist Jan Evangelista Purkyně who identified them in 1837, are a unique type of prominent, large neuron located in the Cerebellum, cerebellar Cortex (anatomy), cortex of the brain. With their flask-shaped cell bodies, many branching Dendrite, dendrites, and a single long axon, these cells are essential for controlling motor activity. Purkinje cells mainly release GABA (gamma-aminobutyric acid) neurotransmitter, which inhibits some neurons to reduce nerve impulse transmission. Purkinje cells efficiently control and coordinate the body's motor motions through these inhibitory actions. Structure These Cell (biology), cells are some of the largest neurons in the human brain (Betz cells being the largest), with an intricately elaborate dendrite, dendritic arbor, characterized by a large number of dendritic spines. Purkinje cells are found within the Purkinje layer in the cerebellum. Purkinje cells are aligned like domi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Leon Cooper
Leon N. Cooper (né Kupchik; February 28, 1930 – October 23, 2024) was an American theoretical physicist and neuroscientist. He won the Nobel Prize in Physics for his work on superconductivity. Cooper developed the concept of Cooper pairs and collaborated with John Bardeen and John Robert Schrieffer to develop the BCS theory of conventional superconductivity. In neuroscience, Cooper co-developed the BCM theory of synaptic plasticity. Biography Childhood and education Leon N. Kupchick was born in the Bronx, New York City on February 28, 1930. His middle initial N. does not stand for anything, though some sources erroneously suggested his middle name was Neil. His father Irving Kupchik was from Belarus and moved to the United States after the Russian Revolution in 1917. His mother Anna (née Zola) Kupchik was from Poland; she died when Leon was seven. His father later changed the family's surname from Kupchick to Cooper when he remarried. Leon attended the Bronx High S ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
