|
Australian Shepherd
The Australian Shepherd is a breed of herding dog from the United States. The name of the breed is technically a misnomer, as it was developed in California in the 19th century. It is believed to have its origins in sheepdog breeds from northwest Spain, as well as collies imported, alongside sheep, from Australia and New Zealand; the breed reportedly took its name from this trade. Originally used solely as a herding dog, the Australian Shepherd has become one of the most popular companion dog breeds in North America. History The Australian Shepherd descends in part from pastoral dogs brought to herd Spanish flocks in North America as early as the 1500s. There is some speculation that these dogs included the Carea Leonés, a mountain sheepdog that can display the eye color and merle coat found in many contemporary Australian Shepherds. It is sometimes claimed that the Basque Shepherd Dog and the Pyrenean Sheepdog were also among the ancestors of the breed. The breed as it is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
United States
The United States of America (USA), also known as the United States (U.S.) or America, is a country primarily located in North America. It is a federal republic of 50 U.S. state, states and a federal capital district, Washington, D.C. The 48 contiguous states border Canada to the north and Mexico to the south, with the semi-exclave of Alaska in the northwest and the archipelago of Hawaii in the Pacific Ocean. The United States asserts sovereignty over five Territories of the United States, major island territories and United States Minor Outlying Islands, various uninhabited islands in Oceania and the Caribbean. It is a megadiverse country, with the world's List of countries and dependencies by area, third-largest land area and List of countries and dependencies by population, third-largest population, exceeding 340 million. Its three Metropolitan statistical areas by population, largest metropolitan areas are New York metropolitan area, New York, Greater Los Angeles, Los Angel ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cataracts (canine)
Canine cataracts are a prevalent cause of visual loss in dogs, frequently resulting in blindness. Cataracts typically occur when proteins break down in the lens of a dog's eye and clump together, obstructing the passage of light. There are several reasons cataracts may occur in dogs, such as heredity, trauma, aging, diabetes, glaucoma, and progressive retinal atrophy Progressive retinal atrophy (PRA) is a group of genetic diseases seen in certain breeds of dogs and, more rarely, cats. Similar to retinitis pigmentosa in humans, it is characterized by the bilateral degeneration of the retina, causing progressi .... Causes Cataracts can be genetic, existing in breeds who are predisposed to developing them. Canine diabetes is another common cause of canine cataracts, due to the increased concentration of glucose in the lens, which swells the lens. A third prevalent cause of canine cataracts is developmental, in which certain embryological conditions, like toxins or infections, ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ivermectin
Ivermectin is an antiparasitic drug. After its discovery in 1975, its first uses were in veterinary medicine to prevent and treat heartworm and acariasis. Approved for human use in 1987, it is used to treat infestations including head lice, scabies, river blindness (onchocerciasis), strongyloidiasis, trichuriasis, ascariasis and lymphatic filariasis. It works through many mechanisms to kill the targeted parasites, and can be taken by mouth, or applied to the skin for external infestations. It belongs to the avermectin family of medications. William Campbell and Satoshi Ōmura were awarded the 2015 Nobel Prize in Physiology or Medicine for its discovery and applications. It is on the World Health Organization's List of Essential Medicines, and is approved by the US Food and Drug Administration (FDA) as an antiparasitic agent. In 2022, it was the 314th most commonly prescribed medication in the United States, with more than 200,000 prescriptions. It is available as ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MDR1
P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. It exists in animals, fungi, and bacteria, and it likely evolved as a defense mechanism against harmful substances. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubule of the kidney where it pumps them into urinary filtrate (in the proximal tubule), and in the capillary endothelial cells composing the blood–brain barrier and blood–testis barrier, where it pumps them back into the capillar ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Autosomal Recessive
In genetics, dominance is the phenomenon of one variant (allele) of a gene on a chromosome masking or overriding the Phenotype, effect of a different variant of the same gene on Homologous chromosome, the other copy of the chromosome. The first variant is termed dominant and the second is called recessive. This state of having Heterozygosity, two different variants of the same gene on each chromosome is originally caused by a mutation in one of the genes, either new (''de novo'') or Heredity, inherited. The terms autosomal dominant or autosomal recessive are used to describe gene variants on non-sex chromosomes (autosomes) and their associated traits, while those on sex chromosomes (allosomes) are termed X-linked dominant, X-linked recessive or Y-linked; these have an inheritance and presentation pattern that depends on the sex of both the parent and the child (see Sex linkage). Since there is only one Y chromosome, Y-linked traits cannot be dominant or recessive. Additionally, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Mongrel
A mongrel, mutt, or mixed-breed dog is a dog that does not belong to one officially recognized breed, including those that result from intentional breeding. Although the term ''mixed-breed dog'' is sometimes preferred, many mongrels have no known purebred ancestors. Crossbreed dogs, and " designer dogs", while also a mix of breeds, differ from mongrels in being intentionally bred. At other times, the word ''mongrel'' has been applied to informally purpose-bred dogs such as curs, which were created at least in part from mongrels, especially if the breed is not officially recognized. Although mongrels are viewed as of less commercial value than intentionally bred dogs, they are thought to be less susceptible to genetic health problems associated with inbreeding (based on the theory of heterosis), and have enthusiasts and defenders who prefer them to intentionally bred dogs. Estimates place the prevalence of mongrels at 150 million animals worldwide. Terminology Mixed-breed ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Docking (dog)
Docking or bobbing is the amputation, removal of portions of an animal's tail. It should not be confused with cropping (animal), ''cropping'', the amputation of ears. Tail docking may be performed cutting the tail with surgical scissors (or a scalpel) or constricting the blood supply to the tail with a rubber ligature (medicine), ligature for a few days until the tail falls off. The length to which tails are docked varies by breed, and is often specified in the breed standard. Docking is illegal, or restricted, in many countries. Some dog breeds have Natural bobtail, naturally occurring bobtail lines. These appear similar to docked dogs but are a distinct naturally occurring phenotype. History Purpose Historically, tail docking was thought to prevent rabies, strengthen the back, increase the animal's speed, and prevent injuries when Rat-baiting, ratting, dog fighting, fighting, and Bait (dogs), baiting. Tail docking is done in modern times either for prophylaxis, prophylactic ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Natural Bobtail
A natural bobtail is an animal's tail which due to a mutated gene grows unusually short or is missing completely. The genes for the shortened tail may be dominant or recessive. Because of legislation restricting or preventing docking, natural bobtails are growing in popularity among the dog fancy for some traditionally docked breeds. For example, one Boxer breeder and geneticist in England has successfully petitioned the Kennel Club for permission to cross Corgis into his lines and then backcross to Boxers, introducing the gene into his lines.The Fantastic Account of Dr Bruce Cattanach’s Bobtail Boxers Virginia Zurflieh, boxerunderground.com, Oct 1998. This would have been unheard of in decades past. A number of these bobtail Boxers have been exported to va ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Merle (dog Coat)
Merle is a genetic pattern in a dog's coat and alleles of the PMEL gene. It results in different colors and patterns and can affect any coats. The allele creates mottled patches of color in a solid or piebald coat, blue or odd-colored eyes, and can affect skin pigment as well. Two types of colored patches generally appear in a merle coat: brown/liver (red merle) and black (blue merle). Associated breeds include Carea Leonés, Australian Shepherds and Catahoula Leopard Dogs. Health issues are more typical and more severe when two merle-patterned dogs are bred together. Description Merle can affect all coat colors. The merle forms of brown are usually called "red" (though this is not correct; red and brown are genetically different), and black is called "blue" as lighter patches of black are formed throughout the coat and look slightly blue in color. Dogs who are recessive red can still be affected by merle, but the patches are either hardly seen or, if the dog is a cle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breed Standard
In animal husbandry or animal fancy, a breed standard is a description of the characteristics of a hypothetical or ideal example of a breed. The description may include phenotype, physical or morphology (biology), morphological detail, genotype, genetic criteria, or criteria of athletic or productive performance. It may also describe faults or deficiencies that would disqualify an animal from registration or from animal reproduction, reproduction. The hypothetical ideal example may be called a "breed type". Breed standards are devised by breed associations or breed clubs, not by individuals, and are written to reflect the use or purpose of the species and breed of the animal. Breed standards help define the ideal animal of a breed and provide goals for breeders in improving stock. In essence a breed standard is a blueprint for an animal fit for the function it was bred - i.e. herding, tracking etc. [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
