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Aspergillus Rugulosus
''Aspergillus rugulosus'' is a species of fungus in the genus ''Aspergillus''. It is from the ''Nidulantes'' section. The species was first described in 1939. It has been isolated from soil in New Jersey, United States. It has been reported to produce sterigmatocystin, arugosin A, arugosin B, arugosin C, asperthecin, aspertetronin A, aspertetronin B, cyclo-L-isoleucyl-L-proline, cyclo-L-leucyl-L-proline, cyclo-L- valyl-L-proline, desferritriacetylfusigen, 3,30-Dihydroxy-5,50-dimethyldiphenyl ether, 2,4-dihydroxy-6- (hydroxymethyl)-benzaldehyde, 2,4-dihydroxy-6- methylbenzaldehyde, 2,4-dihydroxy-6-(hydroxymethyl)-benzaldehyde, echinocandin B, echinocandin C, echinocandin D, epishamixanthone, shamixanthone, 14-Hydroxytajixanthone 25-O-acetate, 14- Methoxytajixanthone 25-O-acetate, 14-Methoxytajixanthone, orsellinaldehyde, penicillin G Benzylpenicillin, also known as penicillin G (PenG) or BENPEN, and in military slang "Peanut Butter Shot" is an antibiotic used to treat a num ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Species
In biology, a species is the basic unit of Taxonomy (biology), classification and a taxonomic rank of an organism, as well as a unit of biodiversity. A species is often defined as the largest group of organisms in which any two individuals of the appropriate sexes or mating types can reproduction, produce Fertility, fertile offspring, typically by sexual reproduction. Other ways of defining species include their karyotype, DNA sequence, morphology (biology), morphology, behaviour or ecological niche. In addition, paleontologists use the concept of the chronospecies since fossil reproduction cannot be examined. The most recent rigorous estimate for the total number of species of eukaryotes is between 8 and 8.7 million. However, only about 14% of these had been described by 2011. All species (except viruses) are given a binomial nomenclature, two-part name, a "binomial". The first part of a binomial is the genus to which the species belongs. The second part is called the specifi ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Fungi Described In 1939
A fungus ( : fungi or funguses) is any member of the group of eukaryotic organisms that includes microorganisms such as yeasts and molds, as well as the more familiar mushrooms. These organisms are classified as a kingdom, separately from the other eukaryotic kingdoms, which by one traditional classification include Plantae, Animalia, Protozoa, and Chromista. A characteristic that places fungi in a different kingdom from plants, bacteria, and some protists is chitin in their cell walls. Fungi, like animals, are heterotrophs; they acquire their food by absorbing dissolved molecules, typically by secreting digestive enzymes into their environment. Fungi do not photosynthesize. Growth is their means of mobility, except for spores (a few of which are flagellated), which may travel through the air or water. Fungi are the principal decomposers in ecological systems. These and other differences place fungi in a single group of related organisms, named the ''Eumycota'' ( ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Penicillin G
Benzylpenicillin, also known as penicillin G (PenG) or BENPEN, and in military slang "Peanut Butter Shot" is an antibiotic used to treat a number of bacterial infections. This includes pneumonia, strep throat, syphilis, necrotizing enterocolitis, diphtheria, gas gangrene, leptospirosis, cellulitis, and tetanus. It is not a first-line agent for pneumococcal meningitis. Due to Benzylpenicillin's limited bioavailability for oral medications, it is generally taken as an injection in the form of a sodium, potassium, benzathine, or procaine salt. Benzylpenicillin is given by injection into a vein or muscle. Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle. Side effects include diarrhea, seizures, and allergic reactions including anaphylaxis. When used to treat syphilis or Lyme disease a reaction known as Jarisch–Herxheimer may occur. It is not recommended in those with a history of penicillin alle ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Orsellinaldehyde
Orsellinaldehyde is a dihydroxybenzaldehyde with a methyl side group. It can be classified as a resorcinol, benzaldehyde or toluene derivative. It is a natural product of several fungi. Fungi that contain it include ''Grifola frondosa'', ''Aspergillus cleistominutus'', '' Aspergillus nidulans'', and ''Agrocybe praecox''. Production Orsellinaldehyde can be produced by a Gattermann reaction The Gattermann reaction, (also known as the Gattermann formylation and the Gattermann salicylaldehyde synthesis) is a chemical reaction in which aromatic compounds are formylated by a mixture of hydrogen cyanide (HCN) and hydrogen chloride (HCl ... of orcinol, using zinc cyanide under a hydrogen chloride atmosphere, which adds an aldimine (-CH=NH) group to the ring, followed by hydrolysis to give the aldehyde. Properties The melting point is between 181 and 183 °C. References {{Reflist Alkylresorcinols Hydroxybenzaldehydes Secondary metabolites ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Echinocandin D
Echinocandins are a class of antifungal drugs that inhibit the synthesis of β-glucan in the fungal cell wall via noncompetitive inhibition of the enzyme 1,3-β glucan synthase. The class has been termed the "penicillin of antifungals," along with the related papulacandins, as their mechanism of action resembles that of penicillin in bacteria. β-glucans are carbohydrate polymers that are cross-linked with other fungal cell wall components, the fungal equivalent to bacterial peptidoglycan. Caspofungin, micafungin, and anidulafungin are semisynthetic echinocandin derivatives with limited clinical use due to their solubility, antifungal spectrum, and pharmacokinetic properties. Medical uses Drugs and drug candidates in this class are fungicidal against some yeasts (most species of ''Candida'', but not '' Cryptococcus'', ''Trichosporon'', and '' Rhodotorula''). Echinocandins also have displayed activity against ''Candida'' biofilms, especially in synergistic activity with amph ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Echinocandin B
Echinocandin B, a lipopeptide, is a naturally occurring cyclic hexapeptide with a linoleoyl side chain. It belongs to a class of antifungal agents called echinocandins, which inhibits the synthesis of glucan, a major component of the fungal cell wall, via noncompetitive inhibition of a crucial enzyme, β-(1→3)-D-glucan synthase. Echinocandin B is a fermentation product of '' Aspergillus nidulans'' and the closely related species, ''A. rugulosus''; discovered in 1974 in ''A. nidulans'' var. ''echinulatus'' strain A 32204 in Germany, it was the first of the echinocandin class of antifungals. Echinocandin B can undergo deacylation (removal of the lipid side chain) by the action of a deacylase enzyme from the filamentous bacterium ''Actinoplanes utahensis ''Actinoplanes utahensis'' is a species of bacteria and a source of the drug acarbose, an alpha-glucosidase inhibitor used in the treatment of diabetes mellitus. Description ''A. utahensis'' are irregular in size and shape. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Genus
Genus ( plural genera ) is a taxonomic rank used in the biological classification of living and fossil organisms as well as viruses. In the hierarchy of biological classification, genus comes above species and below family. In binomial nomenclature, the genus name forms the first part of the binomial species name for each species within the genus. :E.g. '' Panthera leo'' (lion) and '' Panthera onca'' (jaguar) are two species within the genus ''Panthera''. ''Panthera'' is a genus within the family Felidae. The composition of a genus is determined by taxonomists. The standards for genus classification are not strictly codified, so different authorities often produce different classifications for genera. There are some general practices used, however, including the idea that a newly defined genus should fulfill these three criteria to be descriptively useful: # monophyly – all descendants of an ancestral taxon are grouped together (i.e. phylogenetic analysis should c ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
