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Ankyloglossia
Ankyloglossia, also known as tongue-tie, is a congenital oral anomaly that may decrease the mobility of the tongue tip and is caused by an unusually short, thick lingual frenulum, a membrane connecting the underside of the tongue to the floor of the mouth. Ankyloglossia varies in degree of severity from mild cases characterized by mucous membrane bands to complete ankyloglossia whereby the tongue is tethered to the floor of the mouth. Definition Tongue-tie is "a condition that impairs tongue movement due to a restrictive lingual frenulum". As of 2025, no definition, classification system, diagnostic parameters and therefore no definite management parameters have been generally accepted. Cause The cause for tongue tie is unknown. While rearch suggests that tongue-tie could be heritable, most people with it have no inborn diseases. There are associations between X-linked cleft palate syndrome and rare syndromes, including Kindler syndrome, Opitz syndrome, and Van Der Woud ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TBX22
T-box transcription factor TBX22 is a protein that in humans is encoded by the ''TBX22'' gene. TBX22 is a member of a phylogenetically conserved family of proteins that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene have been associated with the inherited X-linked disorder, cleft palate with ankyloglossia (tongue-tie), and it is believed to play a major role in human palatogenesis. It has previously been mapped to the long arm of the X chromosome and it has now been demonstrated that mutations in the gene TBX22 are the cause of this syndrome. TBX22 mutations also result in non-syndromic cleft palate in some populations. TBX22 is composed of seven exons spanning 8.7 kilobases of genomic DNA in Xq21.1. The TBX22 mRNA is 2099 base pairs long and encodes a 400-amino-acids protein containing a T-domain in its NH2-terminal region which has the unique feature of missing ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Lingual Frenulum
The frenulum (or frenum) of the tongue, tongue web, lingual frenulum, frenulum linguae, or fraenulum is a small fold of mucous membrane extending from the floor of the mouth to the midline of the underside of the human tongue. Development The tongue starts to develop at about four weeks. The tongue originates from the first, second, and third pharyngeal arches which induces the migration of muscles from the occipital myotomes. A U-shaped sulcus develops in front of and on both sides of the oral part of the tongue. This allows the tongue to be free and highly mobile, except at the region of the lingual frenulum, where it remains attached. Disturbances during this stage cause tongue tie or ankyloglossia. During the sixth week of gestation, the medial nasal processes approach each other to form a single globular process that in time gives rise to the nasal tip, columella, prolabium, frenulum of the upper lip, and the primary palate. As the tongue continues to develop, frenulum cell ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Breastfeeding
Breastfeeding, also known as nursing, is the process where breast milk is fed to a child. Infants may suck the milk directly from the breast, or milk may be extracted with a Breast pump, pump and then fed to the infant. The World Health Organization (WHO) recommend that breastfeeding begin within the first hour of a baby's birth and continue as the baby wants. Health organizations, including the WHO, recommend breastfeeding exclusively for six months. This means that no other foods or drinks, other than vitamin D, are typically given. The WHO recommends exclusive breastfeeding for the first 6 months of life, followed by continued breastfeeding with appropriate complementary foods for up to 2 years and beyond. Of the 135 million babies born every year, only 42% are breastfed within the first hour of life, only 38% of mothers practice exclusive breastfeeding during the first six months, and 58% of mothers continue breastfeeding up to the age of two years and beyond. Breastfee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Kindler Syndrome
Kindler syndrome (also known as "bullous acrokeratotic poikiloderma of Kindler and Weary") is a type of epidermolysis bullosa, a rare congenital disease presenting with skin blisters, caused by a mutation in the KIND1 gene. Symptoms and signs Infants and young children with Kindler syndrome have a tendency to blister with minor trauma and are prone to sunburns. It has also been associated with ankyloglossia. As individuals with Kindler syndrome age, they tend to have fewer problems with blistering and photosensitivity. However, pigment changes and thinning of the skin become more prominent. In adults, palmoplantar hyperkeratosis can develop and epithelial cancers, such as squamous cell carcinoma typically at acral and mucosal sites. Kindler syndrome can affect various mucous tissues such as the mouth and eyes, which can lead to other health problems, like gingivitis, esophageal stenosis, and colitis. Cause Kindler syndrome is the rarest of the epidermolysis bullosa types w ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Van Der Woude Syndrome
Van der Woude syndrome (VDWS) is a genetic disorder characterized by the combination of lower lip pits, cleft lip with or without cleft palate (CL/P), and cleft palate only (CPO). The frequency of orofacial clefts ranges from 1:1000 to 1:500 births worldwide, and there are more than 400 syndromes that involve CL/P. VWS is distinct from other clefting syndromes due to the combination of cleft lip and palate (CLP) and CPO within the same family. Other features frequently associated with VWS include hypodontia in 10-81% of cases, narrow arched palate, congenital heart disease, heart murmur and cerebral abnormalities, syndactyly of the hands, polythelia, ankyloglossia, and adhesions between the upper and lower gum pads. The association between lower lip pits and cleft lip and/or palate was first described by Anne Van der Woude in 1954. The worldwide disease incidence ranges from 1:100,000 to 1:40,000. Genetics Van der Woude syndrome is inherited as an autosomal dominant disease ca ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Tongue
The tongue is a Muscle, muscular organ (anatomy), organ in the mouth of a typical tetrapod. It manipulates food for chewing and swallowing as part of the digestive system, digestive process, and is the primary organ of taste. The tongue's upper surface (dorsum) is covered by taste buds housed in numerous lingual papillae. It is sensitive and kept moist by saliva and is richly supplied with nerves and blood vessels. The tongue also serves as a natural means of cleaning the teeth. A major function of the tongue is to enable speech in humans and animal communication, vocalization in other animals. The human tongue is divided into two parts, an oral cavity, oral part at the front and a pharynx, pharyngeal part at the back. The left and right sides are also separated along most of its length by a vertical section of connective tissue, fibrous tissue (the lingual septum) that results in a groove, the median sulcus, on the tongue's surface. There are two groups of glossal muscles. The f ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Frenuloplasty Of Tongue
A frenuloplasty of tongue is a frenuloplasty of the frenulum of tongue. A tight frenulum in this context is sometimes referred to as "tongue-tie" which is also known as ankyloglossia. In this condition the frenulum of the tongue restricts range of motion which may interfere with breastfeeding Breastfeeding, also known as nursing, is the process where breast milk is fed to a child. Infants may suck the milk directly from the breast, or milk may be extracted with a Breast pump, pump and then fed to the infant. The World Health Orga ... or speech. A less extensive clipping of the lingual frenulum is known as a frenotomy. See also * Frenectomy References Tongue Tie South Florida Tongue surgery {{Procedures on the mouth and pharynx ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Control Group
In the design of experiments, hypotheses are applied to experimental units in a treatment group. In comparative experiments, members of a control group receive a standard treatment, a placebo, or no treatment at all. There may be more than one treatment group, more than one control group, or both. A placebo control group can be used to support a double-blind study, in which some subjects are given an ineffective treatment (in medical studies typically a sugar pill) to minimize differences in the experiences of subjects in the different groups; this is done in a way that ensures no participant in the experiment (subject or experimenter) knows to which group each subject belongs. In such cases, a third, non-treatment control group can be used to measure the placebo effect directly, as the difference between the responses of placebo subjects and untreated subjects, perhaps paired by age group or other factors (such as being twins). For the conclusions drawn from the results of an ex ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Nipple
The nipple is a raised region of tissue on the surface of the breast from which, in lactating females, breast milk, milk from the mammary gland leaves the body through the lactiferous ducts to Breastfeeding, nurse an infant. The milk can flow through the nipple passively, or it can be ejected by smooth muscles, smooth muscular contraction, muscle contractions that occur along with the ductal system. The nipple is surrounded by the areola, which is often a darker colour than the surrounding skin. Male mammals also have nipples but without the same level of function or prominence. A nipple is often called a ''teat'' when referring to non-humans. "Nipple" or "teat" can also be used to describe the flexible mouthpiece of a baby bottle. In humans, the nipples of both males and females can be sexually stimulated as part of sexual arousal. In many cultures, female nipples are sexualized, or regarded as sex objects and evaluated in terms of their physical characteristics and sex appeal. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Bottle
A bottle is a narrow-necked container made of an impermeable material (such as glass, plastic or aluminium) in various shapes and sizes that stores and transports liquids. Its mouth, at the bottling line, can be sealed with an internal stopper, an external bottle cap, a closure, or induction sealing. Etymology First attested in 14th century. From the English word ''bottle'' derives from an Old French word ''boteille'', from vulgar Latin">-4; we might wonder whether there's a point at which it's appropriate to talk of the beginnings of French, that is, when it wa ... word ''boteille'', from vulgar Latin ''butticula'', from late Latin ''buttis'' ("cask"), a Latinisation (literature), latinisation of the Greek language, Greek βοῦττις (''bouttis'') ("vessel"). Types Glass Wine The glass bottle represented an important development in the history of wine, because, when combined with a high-quality stopper such as a cork, it allowed long-term aging of wine. ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Congenital
A birth defect is an abnormal condition that is present at childbirth, birth, regardless of its cause. Birth defects may result in disability, disabilities that may be physical disability, physical, intellectual disability, intellectual, or developmental disability, developmental. The disabilities can range from mild to severe. Birth defects are divided into two main types: structural disorders in which problems are seen with the shape of a body part and functional disorders in which problems exist with how a body part works. Functional disorders include metabolic disorder, metabolic and degenerative disease, degenerative disorders. Some birth defects include both structural and functional disorders. Birth defects may result from genetic disorder, genetic or chromosome abnormality, chromosomal disorders, exposure to certain medications or chemicals, or certain vertically transmitted infection, infections during pregnancy. Risk factors include folate deficiency, alcohol drink, d ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Surgery
Surgery is a medical specialty that uses manual and instrumental techniques to diagnose or treat pathological conditions (e.g., trauma, disease, injury, malignancy), to alter bodily functions (e.g., malabsorption created by bariatric surgery such as gastric bypass), to reconstruct or alter aesthetics and appearance (cosmetic surgery), or to remove unwanted tissue (biology), tissues (body fat, glands, scars or skin tags) or foreign bodies. The act of performing surgery may be called a surgical procedure or surgical operation, or simply "surgery" or "operation". In this context, the verb "operate" means to perform surgery. The adjective surgical means pertaining to surgery; e.g. surgical instruments, operating theater, surgical facility or surgical nurse. Most surgical procedures are performed by a pair of operators: a surgeon who is the main operator performing the surgery, and a surgical assistant who provides in-procedure manual assistance during surgery. Modern surgical opera ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
