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Alphapithovirus Sibericum
''Alphapithovirus'', is a genus of giant virus known from two species, '' Alphapithovirus sibericum'', which infects amoebas, and '' Alphapithovirus massiliense''. It is DNA-based and is a member of the nucleocytoplasmic large DNA viruses clade. It was discovered in 2014, when a viable specimen was found in a 30,000-year-old ice core harvested from permafrost in Siberia, Russia. Description The genus name ''Alphapithovirus'', a reference to large storage containers of ancient Greece known as pithoi, was chosen to describe the new species. A specimen of ''Alphapithovirus'' measures approximately 1.5 μm (1500 nm) in length and 0.5 μm (500 nm) in diameter, making it one of the largest viruses yet found, second to Megaklothovirus. It is 50% larger in size than the ''Pandoraviridae'', the previous largest-known viruses, and is larger than ''Ostreococcus'', the smallest eukaryotic cell, although ''Pandoravirus'' has the largest viral genome, containing 1.9 to 2.5 m ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gene
In biology, the word gene has two meanings. The Mendelian gene is a basic unit of heredity. The molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. There are two types of molecular genes: protein-coding genes and non-coding genes. During gene expression (the synthesis of Gene product, RNA or protein from a gene), DNA is first transcription (biology), copied into RNA. RNA can be non-coding RNA, directly functional or be the intermediate protein biosynthesis, template for the synthesis of a protein. The transmission of genes to an organism's offspring, is the basis of the inheritance of phenotypic traits from one generation to the next. These genes make up different DNA sequences, together called a genotype, that is specific to every given individual, within the gene pool of the population (biology), population of a given species. The genotype, along with environmental and developmental factors, ultimately determines the phenotype ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Aix-Marseille University
Aix-Marseille University (AMU; ; formally incorporated as ) is a Public university, public research university located in the Provence region of southern France. It was founded in 1409 when Louis II of Anjou, List of rulers of Provence, Count of Provence, petitioned the Council of Pisa, Pisan Antipope Alexander V to establish the University of Provence, making it one of the List of oldest universities in continuous operation, oldest university-level institutions in the Francophone world. The institution came into its current form following a reunification of the University of Provence, the University of the Mediterranean and Paul Cézanne University. The reunification became effective on 1 January 2012, resulting in the creation of the largest university in the List of countries and territories where French is an official language, French-speaking world in terms of its student body, its faculty and staff, and its budget that currently stands at €750 million. The university is or ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Cytoplasm
The cytoplasm describes all the material within a eukaryotic or prokaryotic cell, enclosed by the cell membrane, including the organelles and excluding the nucleus in eukaryotic cells. The material inside the nucleus of a eukaryotic cell and contained within the nuclear membrane is termed the nucleoplasm. The main components of the cytoplasm are the cytosol (a gel-like substance), the cell's internal sub-structures, and various cytoplasmic inclusions. In eukaryotes the cytoplasm also includes the nucleus, and other membrane-bound organelles.The cytoplasm is about 80% water and is usually colorless. The submicroscopic ground cell substance, or cytoplasmic matrix, that remains after the exclusion of the cell organelles and particles is groundplasm. It is the hyaloplasm of light microscopy, a highly complex, polyphasic system in which all resolvable cytoplasmic elements are suspended, including the larger organelles such as the ribosomes, mitochondria, plant plasti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
MRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of Protein biosynthesis, synthesizing a protein. mRNA is created during the process of Transcription (biology), transcription, where an enzyme (RNA polymerase) converts the gene into primary transcript mRNA (also known as pre-mRNA). This pre-mRNA usually still contains introns, regions that will not go on to code for the final amino acid sequence. These are removed in the process of RNA splicing, leaving only exons, regions that will encode the protein. This exon sequence constitutes mature mRNA. Mature mRNA is then read by the ribosome, and the ribosome creates the protein utilizing amino acids carried by transfer RNA (tRNA). This process is known as Translation (biology), translation. All of these processes form part of the central dogma of molecular biology, which describes the flow of geneti ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Open Reading Frame
In molecular biology, reading frames are defined as spans of DNA sequence between the start and stop codons. Usually, this is considered within a studied region of a prokaryotic DNA sequence, where only one of the six possible reading frames will be "open" (the "reading", however, refers to the RNA produced by transcription of the DNA and its subsequent interaction with the ribosome in translation). Such an open reading frame (ORF) may contain a start codon (usually AUG in terms of RNA) and by definition cannot extend beyond a stop codon (usually UAA, UAG or UGA in RNA). That start codon (not necessarily the first) indicates where translation may start. The transcription termination site is located after the ORF, beyond the translation stop codon. If transcription were to cease before the stop codon, an incomplete protein would be made during translation. In eukaryotic genes with multiple exons, introns are removed and exons are then joined together after transcription to ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Base Pair
A base pair (bp) is a fundamental unit of double-stranded nucleic acids consisting of two nucleobases bound to each other by hydrogen bonds. They form the building blocks of the DNA double helix and contribute to the folded structure of both DNA and RNA. Dictated by specific hydrogen bonding patterns, "Watson–Crick" (or "Watson–Crick–Franklin") base pairs (guanine–cytosine and adenine–thymine) allow the DNA helix to maintain a regular helical structure that is subtly dependent on its nucleotide sequence. The Complementarity (molecular biology), complementary nature of this based-paired structure provides a Redundancy (information theory), redundant copy of the genetic information encoded within each strand of DNA. The regular structure and data redundancy provided by the DNA double helix make DNA well suited to the storage of genetic information, while base-pairing between DNA and incoming nucleotides provides the mechanism through which DNA polymerase replicates DNA and ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
DsDNA
Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of all known organisms and many viruses. DNA and ribonucleic acid (RNA) are nucleic acids. Alongside proteins, lipids and complex carbohydrates (polysaccharides), nucleic acids are one of the four major types of macromolecules that are essential for all known forms of life. The two DNA strands are known as polynucleotides as they are composed of simpler monomeric units called nucleotides. Each nucleotide is composed of one of four nitrogen-containing nucleobases (cytosine guanine adenine or thymine , a sugar called deoxyribose, and a phosphate group. The nucleotides are joined to one another in a chain by covalent bonds (known as the phosphodiester linkage) between the sugar of one nucleotide and the phosphate of the next, resulting in ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
GC-content
In molecular biology and genetics, GC-content (or guanine-cytosine content) is the percentage of nitrogenous bases in a DNA or RNA molecule that are either guanine (G) or cytosine (C). This measure indicates the proportion of G and C bases out of an implied four total bases, also including adenine and thymine in DNA and adenine and uracil in RNA. GC-content may be given for a certain fragment of DNA or RNA or for an entire genome. When it refers to a fragment, it may denote the GC-content of an individual gene or section of a gene (domain), a group of genes or gene clusters, a non-coding region, or a synthetic oligonucleotide such as a primer. Structure Qualitatively, guanine (G) and cytosine (C) undergo a specific hydrogen bonding with each other, whereas adenine (A) bonds specifically with thymine (T) in DNA and with uracil (U) in RNA. Quantitatively, each GC base pair is held together by three hydrogen bonds, while AT and AU base pairs are held together by two hydrogen bonds ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Icosahedron
In geometry, an icosahedron ( or ) is a polyhedron with 20 faces. The name comes . The plural can be either "icosahedra" () or "icosahedrons". There are infinitely many non- similar shapes of icosahedra, some of them being more symmetrical than others. The best known is the ( convex, non- stellated) regular icosahedron—one of the Platonic solids—whose faces are 20 equilateral triangles. Regular icosahedra There are two objects, one convex and one nonconvex, that can both be called regular icosahedra. Each has 30 edges and 20 equilateral triangle faces with five meeting at each of its twelve vertices. Both have icosahedral symmetry. The term "regular icosahedron" generally refers to the convex variety, while the nonconvex form is called a ''great icosahedron''. Convex regular icosahedron The convex regular icosahedron is usually referred to simply as the ''regular icosahedron'', one of the five regular Platonic solids, and is represented by its Schläfli symbol , contai ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Iridoviridae
''Iridoviridae'' is a family of viruses with double-stranded DNA genomes. Amphibians, fish, and invertebrates such as arthropods serve as natural hosts. There are currently 22 species in this family, divided among two subfamilies and seven genera. Nomenclature The name is derived from Iris, the Greek goddess of the rainbow. This name was chosen because of the "rainbow-like" iridescence observed in heavily infected insects and pelleted samples of invertebrate iridoviruses. Taxonomy The following subfamilies and genera are recognized (-''virinae'' denotes subfamily and -''virus'' denotes genus): * '' Alphairdovirinae'' ** '' Lymphocystivirus'' ** '' Megalocytivirus'' ** '' Ranavirus'' * '' Betairidovirinae'' ** '' Chloriridovirus'' ** '' Daphniairidovirus'' ** '' Decapodiridovirus'' ** '' Iridovirus'' Structure The virions are icosahedral with triangulation number (T) = 189–217, 120–350 nm in diameter and made up of three domains: an outer proteinaceous capsid, an int ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Megaviridae
''Mimiviridae'' is a family of viruses. Amoeba and other protists serve as natural hosts. The family contains three subfamilies that contain nine genera., UCPMS ID: 1889607PDF/ref> Fig. 4 and §Discussion: "Considering that tupanviruses comprise a sister group to amoebal mimiviruses..." Viruses in this family belong to the nucleocytoplasmic large DNA virus clade (NCLDV), also referred to as giant viruses. History The first member of this family, Mimivirus, was discovered in 2003, and the first complete genome sequence was published in 2004. However, the mimivirus Cafeteria roenbergensis virus was isolated and partially characterized in 1995, although the host was misidentified at the time, and the virus was designated BV-PW1. Taxonomy The family contains the following subfamilies and genera (-''virinae'' denotes subfamily and -''virus'' denotes genus): * '' Aliimimivirinae'' ** '' Rheavirus'' * '' Klosneuvirinae'' ** '' Fadolivirus'' ** '' Theiavirus'' ** '' Yasminevirus ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
