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Alcohol Dementia
Alcohol-related dementia (ARD) is a form of dementia caused by long-term, excessive consumption of alcohol, resulting in neurological damage and impaired cognitive function. Signs and symptoms Alcohol-related dementia presents as a global deterioration in intellectual function with memory not being specifically affected, but it may occur with other forms of dementia, resulting in a wide range of symptoms. Certain individuals with alcohol-related dementia present with damage to the frontal lobes of their brain causing disinhibition, loss of planning and executive functions, and a disregard for the consequences of their behavior. Other types of alcohol-related dementia such as Wernicke encephalopathy cause the destruction of certain areas of the brain, where changes in memory, primarily a loss of short-term memory, are the main symptom. Most presentations of alcohol dementia are somewhere along the spectrum between a global dementia and Korsakoff's psychosis, and may include symptom ...
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Dementia
Dementia is a syndrome associated with many neurodegenerative diseases, characterized by a general decline in cognitive abilities that affects a person's ability to perform activities of daily living, everyday activities. This typically involves problems with memory, thinking, behavior, and motor control. Aside from memory impairment and a thought disorder, disruption in thought patterns, the most common symptoms of dementia include emotional problems, difficulties with language, and decreased motivation. The symptoms may be described as occurring in a continuum (measurement), continuum over several stages. Dementia is a life-limiting condition, having a significant effect on the individual, their caregivers, and their social relationships in general. A diagnosis of dementia requires the observation of a change from a person's usual mental functioning and a greater cognitive decline than might be caused by the normal aging process. Several diseases and injuries to the brain, ...
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Memory
Memory is the faculty of the mind by which data or information is encoded, stored, and retrieved when needed. It is the retention of information over time for the purpose of influencing future action. If past events could not be remembered, it would be impossible for language, relationships, or personal identity to develop. Memory loss is usually described as forgetfulness or amnesia. Memory is often understood as an informational processing system with explicit and implicit functioning that is made up of a sensory processor, short-term (or working) memory, and long-term memory. This can be related to the neuron. The sensory processor allows information from the outside world to be sensed in the form of chemical and physical stimuli and attended to various levels of focus and intent. Working memory serves as an encoding and retrieval processor. Information in the form of stimuli is encoded in accordance with explicit or implicit functions by the working memory p ...
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Health Effects Of Alcohol
Alcohol (also known as ethanol) has a number of effects on health. Short-term effects of alcohol consumption include intoxication and dehydration. Long-term effects of alcohol include changes in the metabolism of the liver and brain, with increased risk of several types of cancer and alcohol use disorder. Alcohol intoxication affects the brain, causing slurred speech, clumsiness, and delayed reflexes. There is an increased risk of developing an alcohol use disorder for teenagers while their brain is still developing. Adolescents who drink have a higher probability of injury including death. Observational studies suggest a correlation between low to moderate alcohol consumption and cardiovascular protective effects. Several studies and meta-analyses have shown a reduction in overall mortality among light to moderate alcohol drinkers compared to lifetime abstainers. A statement from ''The Lancet'' in 2022, based on the 2020 Global Burden of Disease Study, noted that for adults ...
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Graham Kennedy
Graham Cyril Kennedy Order of Australia, AO (15 February 1934 – 25 May 2005) was an Australian entertainer, comedian and variety performer, radio and television host as well as a personality and actor of theatre, television and film. He was often referred to as "The King of Television" or simply "The King" and called "Gra Gra" (pronounced "gray-gray"). Honoured as an officer of the Order of Australia, he was a six-time recipient of the Gold Logie, including the List of Logie Hall of Fame inductees, Logie Hall of Fame award, and won the Star of the Year Award in 1959. He is the most awarded star of Australian television. He was known for his radio and television collaboration's with Bert Newton including on In Melbourne Tonight and The Graham Kennedy Show. Early life Childhood and education Kennedy was born in Camden Street, Balaclava, Victoria, Balaclava, a suburb of Melbourne to Cyril William Kennedy and Mary Austin Kennedy (née Scott). Kennedy's mother, who was 18 ...
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Confounder
In causal inference, a confounder is a variable that influences both the dependent variable and independent variable, causing a spurious association. Confounding is a causal concept, and as such, cannot be described in terms of correlations or associations.Pearl, J., (2009). Simpson's Paradox, Confounding, and Collapsibility In ''Causality: Models, Reasoning and Inference'' (2nd ed.). New York : Cambridge University Press. The existence of confounders is an important quantitative explanation why correlation does not imply causation. Some notations are explicitly designed to identify the existence, possible existence, or non-existence of confounders in causal relationships between elements of a system. Confounders are threats to internal validity. Example Let's assume that a trucking company owns a fleet of trucks made by two different manufacturers. Trucks made by one manufacturer are called "A Trucks" and trucks made by the other manufacturer are called "B Trucks." We ...
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Controlling For A Variable
In causal models, controlling for a variable means binning data according to measured values of the variable. This is typically done so that the variable can no longer act as a confounder in, for example, an observational study or experiment. When estimating the effect of explanatory variables on an outcome by regression, controlled-for variables are included as inputs in order to separate their effects from the explanatory variables. A limitation of controlling for variables is that a causal model is needed to identify important confounders (''backdoor criterion'' is used for the identification). Without having one, a possible confounder might remain unnoticed. Another associated problem is that if a variable which is not a real confounder is controlled for, it may in fact make other variables (possibly not taken into account) become confounders while they were not confounders before. In other cases, controlling for a non-confounding variable may cause underestimation of the ...
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Observational Study
In fields such as epidemiology, social sciences, psychology and statistics, an observational study draws inferences from a sample (statistics), sample to a statistical population, population where the dependent and independent variables, independent variable is not under the Scientific control, control of the researcher because of ethical concerns or logistical constraints. One common observational study is about the possible effect of a treatment on subjects, where the assignment of subjects into a treated group versus a control group is outside the control of the investigator. This is in contrast with experiments, such as randomized controlled trials, where each subject is Random assignment, randomly assigned to a treated group or a control group. Observational studies, for lacking an assignment mechanism, naturally present difficulties for inferential analysis. Motivation The independent variable may be beyond the control of the investigator for a variety of reasons: * A rand ...
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Vladimir Hachinski
Vladimir Hachinski is a Canadian clinical neuroscientist and researcher based at the Schulich School of Medicine and Dentistry at Western University. He is also a Senior Scientist at London's Robarts Research Institute. His research pertains in the greatest part to stroke and dementia, the interactions between them and their joint prevention through holistic brain health promotion. He and John W. Norris helped to establish the world's first successful stroke unit at Sunnybrook Hospital in Toronto, and, by extension, helped cement stroke units as the standard of care for stroke patients everywhere. He discovered that the control of the heart by the brain is asymmetric, the fight/flight (sympathetic) response being controlled by the right hemisphere and the rest and digest (parasympathetic) response being controlled by the left hemisphere and damage to one key component (the insula) can lead to heart irregularities and sudden death. This discovery has added fundamental knowledge ...
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Anomic Aphasia
Anomic aphasia, also known as dysnomia, nominal aphasia, and amnesic aphasia, is a mild, fluent type of aphasia where individuals have word retrieval failures and cannot express the words they want to say (particularly nouns and verbs). By contrast, ''anomia'' is a deficit of expressive language, and a symptom of all forms of aphasia, but patients whose primary deficit is word retrieval are diagnosed with anomic aphasia. Individuals with aphasia who display anomia can often describe an object in detail and maybe even use hand gestures to demonstrate how the object is used, but cannot find the appropriate word to name the object. Patients with anomic aphasia have relatively preserved speech fluency, repetition, comprehension, and grammatical speech. Types * Word selection anomia is caused by damage to the posterior inferior temporal area. This type of anomia occurs when the patient knows how to use an object and can correctly select the target object from a group of objects ...
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Ataxia
Ataxia (from Greek α- negative prefix+ -τάξις rder= "lack of order") is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements, that indicates dysfunction of parts of the nervous system that coordinate movement, such as the cerebellum. These nervous system dysfunctions occur in several different patterns, with different results and different possible causes. Ataxia can be limited to one side of the body, which is referred to as hemiataxia. Friedreich's ataxia has gait abnormality as the most commonly presented symptom. Dystaxia is a mild degree of ataxia. Types Cerebellar The term cerebellar ataxia is used to indicate ataxia due to dysfunction of the cerebellum. The cerebellum is responsible for integrating a significant amount of neural information that is used to coordinate smoothly ongoing movements and to participate in motor planning. A ...
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Standard Drink
A standard drink or (in the UK) unit of alcohol is a measure of alcohol consumption representing a fixed amount of pure alcohol. The notion is used in relation to recommendations about alcohol consumption and its relative risks to health. It helps to inform alcohol users. A hypothetical alcoholic beverage sized to one standard drink varies in volume depending on the alcohol concentration of the beverage (for example, a standard drink of spirits takes up much less space than a standard drink of beer), but it always contains the same amount of alcohol and therefore produces the same amount of intoxication. Many government health guidelines specify low to high risk amounts in units of grams of pure alcohol per day, week, or single occasion. These government guidelines often illustrate these amounts as standard drinks of various beverages, with their serving sizes indicated. Although used for the same purpose, the definition of a standard drink varies from country to country. L ...
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