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Adrenochrome
Adrenochrome is a chemical compound produced by the oxidation of adrenaline (epinephrine). It was the subject of limited research from the 1950s through to the 1970s as a potential cause of schizophrenia. While it has no current medical application, the semicarbazide derivative, carbazochrome, is a hemostatic medication. Despite this compound's name, it is unrelated to the element chromium; instead, the ‑chrome suffix indicates a relationship to color, as pure adrenochrome has a deep violet color. Chemistry The oxidation reaction that converts adrenaline into adrenochrome occurs both ''in vivo'' and ''in vitro''. Silver oxide (Ag2O) was among the first reagents employed for this, but a variety of other oxidizing agents have been used successfully. In solution, adrenochrome is pink and further oxidation of the compound causes it to polymerize into brown or black melanin compounds. Synthesis Adrenochrome is readily synthesized from commercially available reagents: chlo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Abram Hoffer
Abram Hoffer (November 11, 1917 – May 27, 2009) was a Canadian biochemist, physician, and psychiatrist known for his "adrenochrome hypothesis" of schizoaffective disorders. According to Hoffer, megavitamin therapy and other nutritional interventions are potentially effective treatments for cancer and schizophrenia. Hoffer was also involved in studies of LSD as an experimental therapy for alcoholism and the discovery that high-dose niacin can be used to treat high cholesterol and other dyslipidemias. Biography Hoffer was born in the small Jewish settlement of Sonnenfeld in southern Saskatchewan, Canada, in 1917, the last of four children and the son of Israel Hoffer.Dyck, 2008, p26 Originally interested in agriculture, Hoffer earned both a bachelor's and a master's degree in agricultural chemistry from the University of Saskatchewan in Saskatoon. He then took up a scholarship for a year of post-graduate work with the University of Minnesota, followed by work developing assa ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Carbazochrome
Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be used in the future for preventing excessive blood flow during surgical operations and the treatment of hemorrhoids, but research on its effectiveness and the severity of possible side effects remains to be fairly inconclusive. With troxerutin, it has been investigated for use in the treatment of hemorrhoids. __TOC__ Indications Capillary and parenchymal hemorrhage (trauma, tonsillectomy, during surgery), intestinal bleeding, thrombocytopenic purpura. Mechanism of action Carbazochrome, the semicarbazone of adrenochrome, that interacts with α- adrenoreceptors on surface of platelets, which are coupled to Gq protein and initiate PLC IP3/DAG pathway to increase intracellular free calcium concentration with these subsequent actions: * ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Catechol
Catechol ( or ), also known as pyrocatechol or 1,2-dihydroxybenzene, is an organic compound with the molecular formula . It is the ''ortho'' isomer of the three isomeric benzenediols. This colorless compound occurs naturally in trace amounts. It was first discovered by destructive distillation of the plant extract catechin. About 20,000 tonnes of catechol are now synthetically produced annually as a commodity organic chemical, mainly as a precursor to pesticides, flavors, and fragrances. Small amounts of catechol occur in fruits and vegetables. Isolation and synthesis Catechol was first isolated in 1839 by Edgar Hugo Emil Reinsch (1809–1884) by distilling it from the solid tannic preparation catechin, which is the residuum of catechu, the boiled or concentrated juice of ''Mimosa catechu'' ('' Acacia catechu''). Upon heating catechin above its decomposition point, a substance that Reinsch first named ''Brenz-Katechusäure'' (burned catechu acid) sublimated as a white efflo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Neurotoxicity Research
''Neurotoxicity Research'' is a peer-reviewed academic journal covering the study of neurotoxins. It was established in 1999 and is published eight times per year by Springer Science+Business Media. It is the official journal of the Neurotoxicity Society. The editor-in-chief is Richard M. Kostrzewa (East Tennessee State University). According to the ''Journal Citation Reports'', the journal has a 2014 impact factor The impact factor (IF) or journal impact factor (JIF) of an academic journal is a type of journal ranking. Journals with higher impact factor values are considered more prestigious or important within their field. The Impact Factor of a journa ... of 3.538. References External links * Toxicology journals Neuroscience journals Springer Science+Business Media academic journals Academic journals established in 1999 English-language journals 8 times per year journals {{neuroscience-journal-stub ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Derealization
Derealization is an alteration in the perception of the external world, causing those with the condition to perceive it as unreal, distant, distorted, or in other ways falsified. Other symptoms include feeling as if one's environment lacks spontaneity, emotional coloring, and depth. Described as "Experiences of unreality or detachment with respect to surroundings (e.g., individuals or objects are experienced as unreal, dreamlike, foggy, lifeless or visually distorted") in the DSM-5, it is a dissociative symptom that may appear in moments of severe stress. Derealization is a subjective experience pertaining to a person's perception of the outside world, while depersonalization is a related symptom characterized by dissociation from one's own body and mental processes. The two are commonly experienced in conjunction but can also occur independently. Chronic derealization is fairly rare, and may be caused by occipital– temporal dysfunction. Experiencing derealization for long pe ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Thought Disorder
A thought disorder (TD) is a disturbance in cognition which affects language, thought and communication. Psychiatric and psychological glossaries in 2015 and 2017 identified thought disorders as encompassing poverty of ideas, paralogia (a reasoning disorder characterized by expression of illogical or delusional thoughts), word salad, and delusions—all disturbances of thought content and form. Two specific terms have been suggested—content thought disorder (CTD) and formal thought disorder (FTD). CTD has been defined as a thought disturbance characterized by multiple fragmented delusions, and the term ''thought disorder'' is often used to refer to an FTD: a disruption of the form (or structure) of thought. Also known as disorganized thinking, FTD results in disorganized speech and is recognized as a major feature of schizophrenia and other psychoses (including mood disorders, dementia, mania, and neurological diseases). Disorganized speech leads to an inference of disorgani ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Psychotic
In psychopathology, psychosis is a condition in which a person is unable to distinguish, in their experience of life, between what is and is not real. Examples of psychotic symptoms are delusions, hallucinations, and disorganized or incoherent thoughts or speech. Psychosis is a description of a person's state or symptoms, rather than a particular mental illness, and it is not related to psychopathy (a personality construct characterized by impaired empathy and remorse, along with bold, disinhibited, and egocentric traits). Common causes of chronic (i.e. ongoing or repeating) psychosis include schizophrenia or schizoaffective disorder, bipolar disorder, and brain damage (usually as a result of alcoholism). Acute (temporary) psychosis can also be caused by severe distress, sleep deprivation, sensory deprivation, some medications, and drug use (including alcohol, cannabis, hallucinogens, and stimulants). Acute psychosis is termed primary if it results from a psychiatri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
ACS Publications
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all degree levels and in all fields of chemistry, chemical engineering, and related fields. It is one of the world's largest scientific societies by membership. The ACS is a 501(c)(3) non-profit organization and holds a congressional charter under Title 36 of the United States Code. Its headquarters are located in Washington, D.C., and it has a large concentration of staff in Columbus, Ohio. The ACS is a leading source of scientific information through its peer-reviewed scientific journals, national conferences, and the Chemical Abstracts Service. Its publications division produces over 80 scholarly journals including the prestigious '' Journal of the American Chemical Society'', as well as the weekly trade magazine ''Chemical & Engineeri ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Silver Oxide
Silver oxide is the chemical compound with the formula Ag2 O. It is a fine black or dark brown powder that is used to prepare other silver compounds. Preparation Silver oxide can be prepared by combining aqueous solutions of silver nitrate and an alkali hydroxide. This reaction does not afford appreciable amounts of silver hydroxide due to the favorable energetics for the following reaction: :( p''K'' = 2.875) With suitably controlled conditions, this reaction can be used to prepare Ag2O powder with properties suitable for several uses including as a fine grained conductive paste filler. Structure and properties Ag2O features linear, two-coordinate Ag centers linked by tetrahedral oxides. It is isostructural with Cu2O. It "dissolves" in solvents that degrade it. It is slightly soluble in water due to the formation of the ion and possibly related hydrolysis products. It is soluble in ammonia solution, producing active compound of Tollens' reagent. A slurry of Ag2O is readil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrogenated
Hydrogenation is a chemical reaction between molecular hydrogen (H2) and another compound or element, usually in the presence of a catalyst such as nickel, palladium or platinum. The process is commonly employed to reduce or saturate organic compounds. Hydrogenation typically constitutes the addition of pairs of hydrogen atoms to a molecule, often an alkene. Catalysts are required for the reaction to be usable; non-catalytic hydrogenation takes place only at very high temperatures. Hydrogenation reduces double and triple bonds in hydrocarbons. Process Hydrogenation has three components, the unsaturated substrate, the hydrogen (or hydrogen source) and, invariably, a catalyst. The reduction reaction is carried out at different temperatures and pressures depending upon the substrate and the activity of the catalyst. Related or competing reactions The same catalysts and conditions that are used for hydrogenation reactions can also lead to isomerization of the alkenes fr ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Hydrochloride
In chemistry, a hydrochloride is an acid salt resulting, or regarded as resulting, from the reaction of hydrochloric acid with an organic base (e.g. an amine). An alternative name is chlorhydrate, which comes from French. An archaic alternative name is muriate, derived from hydrochloric acid's ancient name: muriatic acid. Uses Converting amines into their hydrochlorides is a common way to improve their water solubility, which can be desirable for substances used in medications. The European Pharmacopoeia lists more than 200 hydrochlorides as active ingredients in medications. These hydrochlorides, compared to free bases, may more readily dissolve in the gastrointestinal tract and be absorbed into the bloodstream more quickly. Additionally, many hydrochlorides of amines have a longer shelf-life than their respective free bases. Amine hydrochlorides represent latent forms of a more reactive free base. In this regard, formation of an amine hydrochloride confers protection ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
