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2019 Bihar Encephalitis Outbreak
In June 2019, an outbreak of acute encephalitis syndrome (AES) occurred in Muzaffarpur and the adjoining districts in Bihar state of India resulting in deaths of more than 150 children, mainly due to hypoglycemia. In subsequent months more cases and deaths were reported. The cause of outbreak is unclear. Malnutrition, climate, hygiene, inadequate health facilities, and lack of awareness are considered as contributing factors. The lychee fruit toxins are also cited as plausible cause of AES. History Outbreaks of acute encephalitis syndrome (AES) have occurred previously in the northern regions of Bihar state and eastern regions of Uttar Pradesh state of India. The first case of AES in Muzaffarpur district was recorded in 1995. There were 143 deaths in 2013, 355 in 2014, 11 in 2015, four in 2016, 11 in 2017 and 7 in 2018. In most recent years, the death toll had remained under 20. Outbreak In June 2019, an outbreak of AES occurred in 222 blocks of Muzaffarpur and the adjoinin ...
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Muzaffarpur District
Muzaffarpur District is one of the thirty-eight districts of Bihar States and territories of India, state, India. Muzaffarpur district is part of and also the headquarters of Tirhut division, Tirhut Division Tirhut is the ancient name of all of northern Bihar. History Muzaffarpur was a part of the ancient Vajjika League, one of the principal Mahajanapada, mahājanapadas of History of India#Iron Age (1500 – 200 BCE), Ancient India. Muzaffarpur fostered political leaders and statesmen alike among whom were Maghfoor Ahmad Ajazi, George Fernandes, Janki Ballabh Shastri, a great Maithili writer Parmanandan Shashtri and Devesh Chandra Thakur. Bajjika and Maithili language, Maithili languages are spoken in the district. In 1972 both Sitamarhi district, Sitamarhi and Vaishali district, Vaishali districts were split from Muzaffarpur. Geography Muzaffarpur district is served by rivers Gandak, Burhi Gandak River, Budhi Gandak, Bagmati River, Bagmati and Lakhandei River, Lakhandei. ...
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All India Institute Of Medical Sciences, Patna
All India Institute of Medical Sciences Patna (AIIMS Patna), previously Jaya Prakash Narayan All India Institute of Medical Sciences (JPNAIIMS), is a medical college and medical research public institute located in Phulwari Sharif, Patna, Bihar, India. It is one of the Institutes of National Importance in India. It started operating on 25 September 2012 after a series of observations by the Patna High Court. The institute operates autonomously under the Ministry of Health and Family Welfare. Its foundation was laid by Bhairon Singh Shekhawat on 3 January 2004, during his tenure as vice-president. , it became fully functional. History In 2004, the central government decided to set up new AIIMS at Rishikesh, Bhopal, Patna, Jodhpur, Bhubaneswar and Raipur. Though the foundation stone for the 350-crore project (2004 estimate) was laid in 2004 during Atal Bihari Vajpayee's tenure, the project was delayed owing to the power shift at the centre, and its cost escalated from to . As ...
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National Institute Of Malaria Research
The National Institute of Malaria Research (NIMR), New Delhi, is one of the research institution of Indian Council of Medical Research under Department of Health Research, Ministry of Health & Family Welfare, Government of India, established in 1977 as Malaria Research Centre, which was renamed as National Institute of Malaria Research in November 2005. The primary task of the Institute is to find short term as well as long-term solutions to the problems of malaria through basic, applied and operational field research. The Institute also plays a key role in manpower resource development through trainings/workshops and transfer of technology. The major areas of research carried out over the years are on mosquito fauna surveys, development of genetic and molecular markers for important malaria vectors and parasites, cytotaxonomic studies identifying major vectors as species complexes and laboratory and field studies to examine the biological variations among sibling species, devel ...
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NIMHANS
The National Institute of Mental Health and Neuro-Sciences is a medical institution in Bangalore, India. NIMHANS is the apex centre for mental health and neuroscience education in the country. It is an Institute of National Importance operates autonomously under the Ministry of Health and Family Welfare. NIMHANS is ranked 4th best medical institute in India, in the current National Institutional Ranking Framework. History The history of the institute dates back to 1847, when the Bangalore Lunatic Asylum was founded. In 1925, the Government of Mysore rechristened the asylum as the Mental Hospital. The Mysore Government Mental Hospital became the first institute in India for postgraduate training in psychiatry. The National Institute of Mental Health and Neurosciences (NIMHANS) was the result of the amalgamation of the erstwhile State Mental Hospital and the All India Institute of Mental Health (AIIMH) established by the Government of India in 1954. The institute was inaugurated ...
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Indian Council Of Medical Research
The Indian Council of Medical Research (ICMR), the apex body in India for the formulation, coordination and promotion of biomedical research, is one of the oldest and largest medical research bodies in the world. The ICMR is funded by the Government of India through the Department of Health Research, Ministry of Health and Family Welfare. In 2007 the organization established the Clinical Trials Registry - India, which is India's national registry for clinical trials. ICMR's 26 national institutes address themselves to research on specific health topics like tuberculosis, leprosy, cholera and diarrhoeal diseases, viral diseases including AIDS, malaria, kala-azar, vector control, nutrition, food & drug toxicology, reproduction, immuno-haematology, oncology, medical statistics, etc. Its 6 regional medical research centres address themselves to regional health problems, and also aim to strengthen or generate research capabilities in different geographic areas of the country. ...
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Intensive Care Unit
220px, Intensive care unit An intensive care unit (ICU), also known as an intensive therapy unit or intensive treatment unit (ITU) or critical care unit (CCU), is a special department of a hospital or health care facility that provides intensive care medicine. Intensive care units cater to patients with severe or life-threatening illnesses and injuries, which require constant care, close supervision from life support equipment and medication in order to ensure normal bodily functions. They are staffed by highly trained physicians, nurses and respiratory therapists who specialize in caring for critically ill patients. ICUs are also distinguished from general hospital wards by a higher staff-to-patient ratio and access to advanced medical resources and equipment that is not routinely available elsewhere. Common conditions that are treated within ICUs include acute respiratory distress syndrome, septic shock, and other life-threatening conditions. Patients may be referred di ...
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India Meteorological Department
The India Meteorological Department (IMD) is an agency of the Ministry of Earth Sciences of the Government of India. It is the principal agency responsible for meteorological observations, weather forecasting and seismology. IMD is headquartered in Delhi and operates hundreds of observation stations across India and Antarctica. Regional offices are at Chennai, Mumbai, Kolkata, Nagpur, Guwahati and New Delhi. IMD is also one of the six Regional Specialised Meteorological Centres of the World Meteorological Organisation. It has the responsibility for forecasting, naming and distribution of warnings for tropical cyclones in the Northern Indian Ocean region, including the Malacca Straits, the Bay of Bengal, the Arabian Sea and the Persian Gulf. History In 1686, Edmond Halley published his treatise on the Indian summer monsoon, which he attributed to a seasonal reversal of winds due to the differential heating of the Asian landmass and the Indian Ocean. The first meteorologi ...
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Harsh Vardhan (Delhi Politician)
Harsh Vardhan (born Harshvardhan Goel, 13 December 1954) is an Indian otorhinolaryngologist. He had served as the Minister of Health and Family Welfare, Minister of Science and Technology and Minister of Earth Sciences in the BJP-led NDA government of Prime Minister Narendra Modi from 30 May 2019 to 7 July 2021. He represents Chandni Chowk in Delhi as a Member of Parliament in the 17th Lok Sabha. He was elected to the office of Chairperson of Executive Board of the World Health Organization from May 22, 2020. Vardhan has been prominent in the Indian government's response to the COVID-19 pandemic. He later resigned from his cabinet post ahead of the cabinet reshuffle in July 2021. As MP Chandni Chowk He was elected as MP of Chandni Chowk in 2014 Lok Sabha elections. He was again elected as MP in 2019 Lok Sabha elections.br> Early life Harsh Vardhan was born in Delhi to Om Prakash Goel and Sneh Lata Goel. Vardhan finished his schooling from Happy School, Daryaganj, in ...
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Ex Gratia
(; also spelled ''ex-gratia'') is Latin for "by favour", and is most often used in a legal context. When something has been done ''ex gratia'', it has been done voluntarily, out of kindness or grace. In law, an ''ex gratia payment'' is a payment made without the giver recognising any liability or legal obligation. Examples Compensation payments are often made ex gratia if a government or organization is prepared to compensate victims of an event such as an accident or similar but not to admit liability to pay compensation or for causing the event. * A company conducting layoffs may make an ex gratia payment to the affected employees that is greater than the statutory payment required by the law, perhaps if those employees had a long and well-performing service with the company. * An insurance company may make an ex gratia payment to customers if a claim does not meet the terms and conditions but the company chooses to make a voluntary payment out of kindness or compassion, wi ...
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Nitish Kumar
Nitish Kumar (born 1 March 1951) is an Indian politician, who is serving as Chief Minister of Bihar since 22 February 2015, having previous held the office from 2005 to 2014 and for a short period in 2000. The leader of the Janata Dal (United), previously he has also served as a Union Minister as the Samata Party member. Kumar first entered politics as a member of the Janata Dal, becoming an MLA in 1985. A socialist, Kumar founded the Samata Party in 1994 along with George Fernandes. In 1996 he was elected to the Lok Sabha, and served as a Union Minister in the government of Atal Bihari Vajpayee, with his party joining the National Democratic Alliance. In 2003 his party merged into the Janata Dal (United), and Kumar became its leader. In 2005, the NDA won a majority in the Bihar Legislative Assembly, and Kumar became chief minister heading a coalition with the Bharatiya Janata Party. In the 2010 state elections, the governing coalition won re-election in a landsli ...
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Hypoglycin A
Hypoglycin A is a naturally occurring amino acid derivative found in the unripened fruit of the Ackee tree (''Blighia sapida'') and in the seeds of the box elder tree (''Acer negundo''). It is toxic if ingested, and is the causative agent of Jamaican vomiting sickness. A 2017 Lancet report established a link between the consumption of unripened lychees (containing hypoglycin A or methylenecyclopropylglycine (MCPG)) resulting in hypoglycaemia and death from acute toxic encephalopathy. Sources The entirety of the unripe Ackee fruit is toxic and contains large amounts of hypoglycin. The fruit is safe to eat only when the fruit is allowed to fully open and expose the large black seeds while on the tree. The levels of the toxin decrease over time though from approximately 1000 ppm to around 0.1 ppm in the mature fruit. Relatives of Ackee, including lychee, longan, and rambutan, can contain enough α-(methylenecyclopropyl)glycine, a homologue of hypoglycin A, in their fruit to c ...
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Methylene Cyclopropyl Acetic Acid
Methylene cyclopropyl acetic acid (MCPA) is found in lychee seeds and also a toxic metabolite in mammalian digestion after ingestion of hypoglycin. Overview Methylene cyclopropyl acetic acid (MCPA) is a compound found in lychee ('' Litchi chinensis'') seeds.Gray DO, FowdeL. alpha-(methylenecyclopropyl)glycine from litchi seeds.Biochem J 1962;82:385–9. It is also a metabolite in mammalian digestion after ingestion of hypoglycin, a rare and potentially toxic amino acid, chemically related to the common amino acid lysine. Hypoglycin is found in the unripe ackee fruit in Africa. Dihydrosterculic acid is the major carbocyclic fatty acid in the seed oils of ''Litchi chinensis''. It is a cyclopropane fatty acid; these have been found in many plants of the order Malvales ( Malvaceae), in up to 60% of seed oil content, depending on the species but also in leaves, roots and shoots. They are accompanied by small amounts of their cyclopropanoid analogues, i.e. cyclopropyl acetic aci ...
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