Xiaowei Zhuang (; born January 1972) is a Chinese-American

biophysicist Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. Bi ...

who is the David B. Arnold Jr. Professor of Science, Professor of Chemistry and Chemical Biology, and Professor of Physics at

Harvard University Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of highe ...

, and an Investigator at the

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fi ...

. She is best known for her work in the development of Stochastic Optical Reconstruction Microscopy (STORM), a super-resolution fluorescence microscopy method, and the discoveries of novel cellular structures using STORM. She received a 2019

Breakthrough Prize in Life Sciences The Breakthrough Prize in Life Sciences is a scientific award, funded by internet entrepreneurs Mark Zuckerberg and Priscilla Chan of Facebook; Sergey Brin of Google; entrepreneur and venture capitalist Yuri Milner; and Anne Wojcicki, one of the ...

for developing super-resolution imaging techniques that get past the diffraction limits of traditional light microscopes, allowing scientists to visualize small structures within living cells. She was elected a Member of the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

in 2019 and was awarded a

Vilcek Foundation The Vilcek Foundation raises awareness of immigrant contributions to the United States, and fosters appreciation of the arts and sciences. The foundation's flagship programs include the Vilcek Foundation Prizes, which recognize and support immigra ...

Prize in Biomedical Science in 2020.

Early life and education

Zhuang's father Zhuang Lixian () and mother Zhu Renzhi () are both professors at the

University of Science and Technology of China A university () is an institution of higher (or tertiary) education and research which awards academic degree An academic degree is a qualification awarded to students upon successful completion of a course of study in higher education, usua ...

(USTC). Zhuang graduated from the USTC with a B.S. in Physics in 1991. She obtained her Ph.D. in Physics from the

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...

in 1996 and conducted her thesis research under the supervision of Dr. Yuen-Ron Shen. In 1997-2001, she was a Chodorow Postdoctoral Fellow in the laboratory of Dr.

Steven Chu Steven ChuStanford University Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is conside ...

. She started her faculty position in the Department of Chemistry and Chemical Biology and the Department of Physics at

in 2001 and was promoted to full professor in 2006. She was named a Howard Hughes Medical Investigator in 2005.

Research

Zhuang's laboratory invented Stochastic Optical Reconstruction Microscopy (STORM), a single-molecule-based super-resolution fluorescence microscopy method. The Zhuang laboratory demonstrated three-dimensional super-resolution imaging with STORM. The Zhuang laboratory also discovered several photoswitchable dye molecules that enabled STORM imaging and demonstrated live-cell STORM imaging. Using STORM, Zhuang and colleagues have studied a variety of biological systems, ranging from single-cell organisms to complex brain tissues. These studies led to the discovery of novel cellular structures, such as the periodic membrane skeletons in the axons of neurons and provided insights into many other cellular structures. The Zhuang laboratory invented a single-cell transcriptome imaging method, MERFISH (multiplexed error-robust fluorescence in situ hybridization), which allows numerous RNA species to be imaged and quantified in single cells in their native context. Zhuang and colleagues used single-molecule FRET to study biomolecules and molecular complexes and developed single-virus tracking methods to study virus-cell interactions.

Honors and awards

* 2022:

Heinrich Wieland Prize The Heinrich Wieland Prize is awarded annually by the Boehringer Ingelheim Foundation for outstanding research on biologically active molecules and systems in the areas of chemistry, biochemistry and physiology as well as their clinical importance. ...

* 2021:

Lurie Prize in Biomedical Sciences The Lurie Prize in Biomedical Sciences recognizes outstanding achievement by a promising young scientist in biomedical research. It is awarded annually by the Foundation for the National Institutes of Health. Established in 2013 the award is wo ...

* 2020:

Prize in

Biomedical Science Biomedical sciences are a set of sciences applying portions of natural science or formal science, or both, to develop knowledge, interventions, or technology that are of use in healthcare or public health. Such disciplines as medical microbi ...

* 2019:

Pearl Meister Greengard Prize The Pearl Meister Greengard Prize is an award for women scientists in biology given annually by the Rockefeller University. The Prize was founded by Nobel laureate Paul Greengard and his wife Ursula von Rydingsvard in honor of Greengard's moth ...

* 2019: NAS Award for Scientific Discovery * 2019:

* 2018: Dr. H.P. Heineken Prize for Biochemistry and Biophysics,

Royal Netherlands Academy of Arts and Sciences The Royal Netherlands Academy of Arts and Sciences ( nl, Koninklijke Nederlandse Akademie van Wetenschappen, abbreviated: KNAW) is an organization dedicated to the advancement of science and literature in the Netherlands. The academy is housed ...

* 2018: Pittsburgh Analytical Chemistry Award * 2017: Honorary doctorate, Delft University of Technology * 2017: Lennart Nilsson Award, Karolinska Institute, Sweden * 2016: Doctor of Philosophy Honoris Causa, Stockholm University * 2015: Foreign academician of the

Chinese Academy of Sciences The Chinese Academy of Sciences (CAS); ), known by Academia Sinica in English until the 1980s, is the national academy of the People's Republic of China for natural sciences. It has historical origins in the Academia Sinica during the Republi ...

http://www.cas.cn/tz/201512/t20151207_4488383.shtml 关于公布2015年中国科学院院士增选当选院士名单的公告 * 2015:

NAS Award in Molecular Biology The NAS Award in Molecular Biology is awarded by the U.S. National Academy of Sciences "for recent notable discovery in molecular biology by a young scientist who is a citizen of the United States." It has been awarded annually since its inception ...

* 2013: Member

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

* 2012: Member

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

* 2012: Fellow

American Physical Society The American Physical Society (APS) is a not-for-profit membership organization of professionals in physics and related disciplines, comprising nearly fifty divisions, sections, and other units. Its mission is the advancement and diffusion of k ...

* 2012: Fellow

American Association for the Advancement of Science The American Association for the Advancement of Science (AAAS) is an American international non-profit organization with the stated goals of promoting cooperation among scientists, defending scientific freedom, encouraging scientific respons ...

* 2011:

Sackler Prize The Sackler Prize can indicate any of the following three awards established by Raymond Sackler and his wife Beverly Sackler currently bestowed by the Tel Aviv University. Sackler Prize in the Physical Sciences The Raymond and Beverly Sackler Int ...

* 2010:

Max Delbruck Prize The Max Delbruck Prize, formerly known as the Biological physics prize, is awarded by the Division of Biological Physics of the American Physical Society, to recognize and encourage outstanding achievement in biological physics research. The pr ...

* 2008: Coblentz Award * 2007: ACS Award in Pure Chemistry * 2004:

Sloan Fellowship The Sloan Research Fellowships are awarded annually by the Alfred P. Sloan Foundation since 1955 to "provide support and recognition to early-career scientists and scholars". This program is one of the oldest of its kind in the United States. ...

* 2003:

Packard Fellowship The David and Lucile Packard Foundation is a private foundation that provides grants to not-for-profit organizations. It was created in 1964 by David Packard (co-founder of HP) and his wife Lucile Salter Packard. Following David Packard's death ...

* 2003:

MacArthur Fellows Program The MacArthur Fellows Program, also known as the MacArthur Fellowship and commonly but unofficially known as the "Genius Grant", is a prize awarded annually by the John D. and Catherine T. MacArthur Foundation typically to between 20 and 30 indi ...

* 2003:

Beckman Young Investigators Award The Beckman Young Investigators Award was established by Mabel and Arnold Beckman in 1991, and is now administered by the Arnold and Mabel Beckman Foundation. The Beckman Young Investigator (BYI) Program is intended to provide research support to p ...

References

{{DEFAULTSORT:Zhuang, Xiaowei 1972 births Living people American biophysicists Harvard University faculty Howard Hughes Medical Investigators MacArthur Fellows UC Berkeley College of Letters and Science alumni University of Science and Technology of China alumni Members of the United States National Academy of Sciences Foreign members of the Chinese Academy of Sciences Scientists from Nantong Chinese emigrants to the United States Chinese biophysicists American women biologists Chinese women biologists American women physicists Chinese women physicists Physicists from Jiangsu Educators from Nantong Members of the American Philosophical Society Biologists from Jiangsu People from Rugao Women in optics American women academics 21st-century American women Fellows of the American Physical Society