The Wellcome Centre for Human Genetics is a

human genetics Human genetics is the study of inheritance as it occurs in human beings. Human genetics encompasses a variety of overlapping fields including: classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population gene ...

research centre of the Nuffield Department of Medicine in the

Medical Sciences Division, University of Oxford The various academic faculties, departments, and institutes of the University of Oxford are organised into four divisions, each with its own Head and elected board. They are the Humanities Division; the Social Sciences Division; the Mathematical ...

, funded by the

Wellcome Trust The Wellcome Trust is a charitable foundation focused on health research based in London, in the United Kingdom. It was established in 1936 with legacies from the pharmaceutical magnate Henry Wellcome (founder of one of the predecessors of Glaxo ...

among others. Henry Wellcome Building for Genomic Medicine

Facilities & resources

The centre is located at the

Henry Wellcome Sir Henry Solomon Wellcome (August 21, 1853 – July 25, 1936) was an American pharmaceutical entrepreneur. He founded the pharmaceutical company Burroughs Wellcome & Company with his colleague Silas Burroughs in 1880, which is one of the fo ...

Building of Genomic Medicine, which cost £20 million and was officially opened in June 2000 with

Anthony Monaco Anthony P. Monaco (born October 10, 1959) is an American geneticist and university administrator. He has been president of Tufts University since 2011. Life Monaco was born in Wilmington, Delaware and graduated from the Salesianum School in 197 ...

as the director. Within the WHG a number of 'cores' provide services to the researchers:

Oxford Genomics Centre

The Oxford Genomics Centre provides high throughput sequencing services, using Illumina HiSeq4000 2500 and NextSeq500 and MiSeq. They also offer Oxford Nanopore MinION and PromethION sequencing. There are also Array platforms for genotyping, gene expression, and methylation including Illuminia Infinium, Affymetrix and

Fluidigm Standard BioTools Inc. (formerly Fluidigm) is an American company engaged in the design, manufacture and sale of biological research equipment based on integrated fluidic circuit technology. The company's founders leveraged their semiconductor ...

Research Computing Core

The Research Computing Core provides access to computer resources including 4120 cores and 4.2 PB of storage.

Transgenics

The Transgenics Core provides access to genetically modified mice and cell lines.

Cellular Imaging

Cellular Imaging Core provides microscopy facilities including fluorescence microscopy (including Fluorescence Correlation Spectroscopy ( FCS), Fluorescence Lifetime Correlation Spectroscopy ( FLCS), Fluorescence Lifetime Imaging Microscopy ( FLIM), Total Internal Reflection Fluorescence Microscopy ( TIRF), Photoactivated Localisation Microscopy (

PALM Palm most commonly refers to: * Palm of the hand, the central region of the front of the hand * Palm plants, of family Arecaceae **List of Arecaceae genera * Several other plants known as "palm" Palm or Palms may also refer to: Music * Palm (ba ...

), Spectral Imaging ( SI) and Single Particle Tracking ( SPT).

Research

Statistical and population genetics

The WHG has been involved in many international statistical genetics advances including the Wellcome Trust Case Control Consortia (WTCCC, WTCCC2), the

1000 Genomes Project The 1000 Genomes Project (abbreviated as 1KGP), launched in January 2008, was an international research effort to establish by far the most detailed catalogue of human genetic variation. Scientists planned to sequence the genomes of at least one th ...

and the International

HapMap Project The International HapMap Project was an organization that aimed to develop a haplotype map (HapMap) of the human genome, to describe the common patterns of human genetic variation. HapMap is used to find genetic variants affecting health, disease ...

References

1994 establishments in England Biotechnology in the United Kingdom Departments of the University of Oxford Educational institutions established in 1994 Genetics in the United Kingdom Genetics or genomics research institutions Research institutes in Oxford Wellcome Trust Medical research institutes in the United Kingdom Human genetics {{genetics-stub