VU-0238429 is a drug which acts as a selective
positive allosteric modulator
In pharmacology and biochemistry, allosteric modulators are a group of substances that bind to a receptor to change that receptor's response to stimulus. Some of them, like benzodiazepines, are drugs. The site that an allosteric modulator binds to ...
for the
muscarinic acetylcholine receptor M5. It was the first selective ligand developed for the M
5 subtype,
and is structurally derived from older
M1-selective positive allosteric modulators such as
VU-0119498.
Replacing the
''O''-methyl- by a
phenyl group further improves the receptor subtype selectivity.
References
{{Muscarinic acetylcholine receptor modulators
Muscarinic agonists
Trifluoromethyl ethers
Indoles