(S)-UH-301 is a

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via inhala ...

and research chemical widely used in scientific studies. It acts as a selective 5-HT_1A

receptor Receptor may refer to: *Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...

silent antagonist A receptor antagonist is a type of receptor ligand or drug that blocks or dampens a biological response by binding to and blocking a receptor rather than activating it like an agonist. Antagonist drugs interfere in the natural operation of recep ...

. It is structurally related to 8-OH-DPAT. UH-301 was found to produce a

head-twitch response The head-twitch response (HTR) is a rapid side-to-side head movement that occurs in mice and rats after the serotonin 5-HT2A receptor is activated. The prefrontal cortex may be the neuroanatomical locus mediating the HTR. Many serotonergic hallucino ...

in mice which is usually typical of 5-HT_2A agonist drugs, and has subsequently been used to investigate how 5-HT_1A receptor activity modulates 5-HT_2A receptors downstream.

References

5-HT1A antagonists Phenols Fluoroarenes Aminotetralins {{nervous-system-drug-stub

See also

References