Tryptophan tryptophylquinone (TTQ) is an enzyme
cofactor, generated by
posttranslational modification
Post-translational modification (PTM) is the covalent and generally enzymatic modification of proteins following protein biosynthesis. This process occurs in the endoplasmic reticulum and the golgi apparatus. Proteins are synthesized by ribos ...
of
amino acid
Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha ...
s within the protein. Methylamine dehydrogenase (MADH), an
amine dehydrogenase
Amine Dehydrogenase (), also known as methylamine dehydrogenase (MADH), is a tryptophan tryptophylquinone-dependent (TTQ-dependent) enzyme that catalyzes the oxidative deamination of a primary amine to an aldehyde and ammonia. The reaction occurs ...
, requires TTQ for its
catalytic function.
See also
*
Amicyanin
References
Amino acid derivatives
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