Riamilovir (TZV, Triazavirin) is a broad-spectrum

antiviral drug Antiviral drugs are a class of medication used for treating viral infections. Most antivirals target specific viruses, while a broad-spectrum antiviral is effective against a wide range of viruses. Unlike most antibiotics, antiviral drugs do n ...

developed in Russia through a joint effort of Ural Federal University, Russian Academy of Sciences, Ural Center for Biopharma Technologies and Medsintez Pharmaceutical. It has a novel triazolotriazine core, which represents a new structural class of non-nucleoside antiviral drugs. The main principle action of triazavirin is to inhibit the synthesis of viral ribonucleic acid (RNA) and the replication of viral genomic fragments through its synthetic analogue to the bases of purine nucleosides.

Uses

It was originally developed as a potential treatment for pandemic

influenza Influenza, commonly known as "the flu", is an infectious disease caused by influenza viruses. Symptoms range from mild to severe and often include fever, runny nose, sore throat, muscle pain, headache, coughing, and fatigue. These symptoms ...

strains such as H5N1, and most of the testing that has been done has focused on its anti-influenza activity. However, triazavirin has also been found to have antiviral activity against a number of other viruses including tick-borne encephalitis virus, and is also being investigated for potential application against a lethal influenza infection and secondary bacterial pneumonia following influenza, Lassa fever and

Ebola virus disease Ebola, also known as Ebola virus disease (EVD) and Ebola hemorrhagic fever (EHF), is a viral hemorrhagic fever in humans and other primates, caused by ebolaviruses. Symptoms typically start anywhere between two days and three weeks after becom ...

. Triazavirin has passed clinical trials and has shown antiviral activity against ARVI. In 2020, testing of triazavirin was started against SARS-CoV-2 in Russia, China, and South Africa. «Discussion on Russia's antiviral drug Triazavirin». SABC News. 21 January 2021. https://www.youtube.com/watch?v=qbMpopd7N14&t=22s In August 2014, the Ministry of Health of Russia issued a registration certificate for triazavirin. The active substance of the drug triazavirin is a new active molecule, and can be dispensed by prescription. The production of triazavirin is carried out at a modern pharmaceutical enterprise LLC "Plant Medsintez". The registration procedure for triazavirin has begun in the Republic of South Africa.

Criticism

The studies of Triazavirin were non-blinded and non-randomized, and included 66 patients only with, with 44 in a control group. Original publication by Tikhonova et al
/ref>

References

Antiviral drugs Experimental drugs Lactams Thioethers Nitrogen heterocycles Heterocyclic compounds with 2 rings Russian drugs Russian inventions Triazoles {{antiinfective-drug-stub

Uses

Criticism

See also

References