Transforming growth interacting factor (TGIF) is a potential repressor of
TGF-β
Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different mammalian isoforms (TGF-β 1 to 3, HGNC symbols TGFB1, TGFB2, TGFB3) and many other sign ...
pathways in
myometrial cells.
Expression of TGIF is increased in
uterine leiomyoma
Uterine fibroids, also known as uterine leiomyomas or fibroids, are benign smooth muscle tumors of the uterus. Most women with fibroids have no symptoms while others may have painful or heavy periods. If large enough, they may push on the bl ...
compared with myometrium.
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References
{{TGFβ receptor superfamily modulators
TGFβ domain