Tolibut, also known as 3-(''p''-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is
drug that was developed in
Russia
Russia (, , ), or the Russian Federation, is a transcontinental country spanning Eastern Europe and Northern Asia. It is the largest country in the world, with its internationally recognised territory covering , and encompassing one-eig ...
. It is an
analogue of
γ-aminobutyric acid (GABA) (that is, a
GABA analogue
A GABA analogue is a compound which is an analogue or derivative of the neurotransmitter gamma-Aminobutyric acid (GABA) (the IUPAC of which is 4-aminobutanoic acid).
Many GABA analogues are used as drugs, especially as anticonvulsants, sedative ...
) and is the 4-methyl analogue of
phenibut, and is also an analogue of
baclofen
Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity such as from a spinal cord injury or multiple sclerosis. It may also be used for hiccups and muscle spasms near the end of life. It is ta ...
where the 4-chloro substitution has been replaced with a 4-methyl substitution. Tolibut has been described as possessing
analgesic,
tranquilizing, and
neuroprotective
Neuroprotection refers to the relative preservation of neuronal structure and/or function. In the case of an ongoing insult (a neurodegenerative insult) the relative preservation of neuronal integrity implies a reduction in the rate of neuronal los ...
properties. It is not fully clear as to whether the drug was ever approved or used medically in Russia, though it may have been.
See also
* 4-Fluorophenibut
References
Abandoned drugs
Analgesics
Anxiolytics
GABA analogues
Neuroprotective agents
Russian drugs
4-Tolyl compounds
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