Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''TMPO''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
LAP2 is an
inner nuclear membrane (INM) protein.
Thymopoietin is a protein involved in the induction of
CD90
Thy-1 or CD90 (Cluster of Differentiation 90) is a 25–37 k Da heavily N-glycosylated, glycophosphatidylinositol (GPI) anchored conserved cell surface protein with a single V-like immunoglobulin domain, originally discovered as a thymocyte anti ...
in the
thymus
The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or '' T cells'' mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders ...
. The thymopoetin (TMPO) gene encodes three alternatively spliced mRNAs encoding proteins of 75 kDa (alpha), 51 kDa (beta) and 39 kDa (gamma) which are ubiquitously expressed in all cells. The human TMPO gene maps to chromosome band 12q22 and consists of eight exons. TMPO alpha is present diffusely expressed with the cell nucleus while TMPO beta and gamma are localized to the nuclear membrane. TMPO beta is a human homolog of the murine protein LAP2. LAP2 plays a role in the regulation of nuclear architecture by binding lamin B1 and chromosomes. This interaction is regulated by phosphorylation during mitosis. Given the nuclear localization of the three TMPO isoforms, it is unlikely that these proteins play any role in CD90 induction.
Interactions
Thymopoietin has been shown to
interact
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with
Barrier to autointegration factor 1
Barrier-to-autointegration factor is a protein that in humans is encoded by the ''BANF1'' gene. It is a member of the barrier-to-autointegration factor family of proteins.
Function
The protein encoded by this gene was identified by its abilit ...
,
AKAP8L
A-kinase anchor protein 8-like is a protein that in humans is encoded by the ''AKAP8L'' gene.
Interactions
AKAP8L has been shown to interact with:
* DHX9, and
* Thymopoietin
Lamina-associated polypeptide 2 (LAP2), isoforms beta/gamma is a p ...
,
LMNB1
Lamin-B1 is a protein that in humans is encoded by the ''LMNB1'' gene.
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highl ...
and
LMNA
Pre-lamin A/C or lamin A/C is a protein that in humans is encoded by the ''LMNA'' gene. Lamin A/C belongs to the lamin family of proteins.
Function
In the setting of ZMPSTE24 deficiency, the final step of lamin processing does not occur, r ...
.
References
Further reading
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External links
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{{Hormones
Proteins