Thrombopoietin mimetics are
drugs that considerably increase
platelet
Platelets, also called thrombocytes (from Greek θρόμβος, "clot" and κύτος, "cell"), are a component of blood whose function (along with the coagulation factors) is to react to bleeding from blood vessel injury by clumping, thereby i ...
production by stimulating the receptor for the hormone
thrombopoietin
Thrombopoietin (THPO) also known as megakaryocyte growth and development factor (MGDF) is a protein that in humans is encoded by the ''THPO'' gene.
Thrombopoietin is a glycoprotein hormone produced by the liver and kidney which regulates the pro ...
;
Romiplostim
Romiplostim, sold under the brand name Nplate among others, is a fusion protein analog of thrombopoietin, a hormone that regulates platelet production.
Indications and Marketing
The drug was developed by Amgen through a restricted usage program ...
and
Eltrombopag
Eltrombopag, sold under the brand name Promacta among others, is a medication used to treat thrombocytopenia (abnormally low platelet counts) and severe aplastic anemia. Eltrombopag is sold under the brand name Revolade outside the US and is mar ...
are examples. Thrombopoietin mimetics are a type of
thrombopoietic agent Thrombopoietic agents are drugs that induce the growth and maturation of megakaryocytes. Some of them are currently in clinical use: romiplostim, eltrombopag, oprelvekin (a recombinant interleukin 11) and thrombopoietin
Thrombopoietin (THPO) als ...
s. There has been a development of a registry of
pregnant patients that were treated with these drugs.
References
{{Cytokine receptor modulators
Thrombopoietin receptor agonists