Theodor Heinrich Boveri (12 October 1862 – 15 October 1915) was a German

zoologist Zoology ()The pronunciation of zoology as is usually regarded as nonstandard, though it is not uncommon. is the branch of biology that studies the animal kingdom, including the structure, embryology, evolution, classification, habits, and d ...

, comparative anatomist and co-founder of modern

cytology Cell biology (also cellular biology or cytology) is a branch of biology that studies the structure, function, and behavior of cells. All living organisms are made of cells. A cell is the basic unit of life that is responsible for the living an ...

. He was notable for the first hypothesis regarding cellular processes that cause

cancer Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

, and for describing ''

chromatin Chromatin is a complex of DNA and protein found in eukaryotic cells. The primary function is to package long DNA molecules into more compact, denser structures. This prevents the strands from becoming tangled and also plays important roles in r ...

diminution in nematodes''. Boveri was married to the American biologist Marcella O'Grady (1863–1950). Their daughter Margret Boveri (1900–1975) became one of the best-known journalists in post-World War II Germany.

Work

Using an optical microscope, Boveri examined the processes involved in the fertilization of the animal egg cell; his favorite research objects were the nematode '' Parascaris'' and sea urchins. Boveri's work with sea urchins showed that it was necessary to have all

chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

s present in order for proper embryonic development to take place. This discovery was an important part of the Boveri–Sutton chromosome theory. He also discovered, in 1888, the importance of the

centrosome In cell biology, the centrosome (Latin centrum 'center' + Greek sōma 'body') (archaically cytocentre) is an organelle that serves as the main microtubule organizing center (MTOC) of the animal cell, as well as a regulator of cell-cycle prog ...

for the formation of the spindle during mitosis in animal cells, which he described as the ''especial organ of cell division''. Boveri also discovered the phenomenon of

diminution during embryonic development of the nematode ''Parascaris''. Building on Carl Rabl's knowledge that chromosomes are also present between two nuclear divisions in the cell nucleus, he developed the concept of chromosome individuality, i.e. the assumption that chromosomes retain their individuality during interphase. Through long experiments on sea urchin eggs, he was also able to prove that the various 『chromosomes contain different genetic makeup』. He also reasoned in 1902 that a

cancerous tumor Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. These contrast with benign tumors, which do not spread. Possible signs and symptoms include a lump, abnormal b ...

begins with a single

cell Cell most often refers to: * Cell (biology), the functional basic unit of life Cell may also refer to: Locations * Monastic cell, a small room, hut, or cave in which a religious recluse lives, alternatively the small precursor of a monastery ...

in which the makeup of its chromosomes becomes scrambled, causing the cells to divide uncontrollably. He proposed carcinogenesis was the result of aberrant mitoses and uncontrolled growth caused by radiation, physical or chemical insults or by microscopic

pathogens In biology, a pathogen ( el, πάθος, "suffering", "passion" and , "producer of") in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a ger ...

. His assumption was initially rejected by medical professionals; it was only later that researchers such as

Thomas Hunt Morgan Thomas Hunt Morgan (September 25, 1866 – December 4, 1945) was an American evolutionary biologist, geneticist, embryologist, and science author who won the Nobel Prize in Physiology or Medicine in 1933 for discoveries elucidating the role that ...

in 1915 demonstrated that Boveri was correct. ''given Chromosomal theory of inheritance “theodori boveri &sutton”'' Boveri also described the structure of the kidneys in ''

Amphioxus The lancelets ( or ), also known as amphioxi (singular: amphioxus ), consist of some 30 to 35 species of "fish-like" benthic filter feeding chordates in the order Amphioxiformes. They are the modern representatives of the subphylum Cephalochorda ...

'' (

Cephalochordata A cephalochordate (from Greek: κεφαλή ''kephalé'', "head" and χορδή ''khordé'', "chord") is an animal in the chordate subphylum, Cephalochordata. They are commonly called lancelets. Cephalochordates possess 5 synapomorphies, or prima ...

References

External links

*Fritz Baltzer (1967), excerpt fro
Theodor Boveri: The life of a great biologist, 1862–1915
University of California Press, Berkeley; pp. 85–97. *Markus Engstler and Ulrich Scheer
Theodor Boveri Resources and Virtual Library in Wuerzburg
*Peter Wolbert
Theodor Boveri (1862-1915)
{{DEFAULTSORT:Boveri, Theodor 1862 births 1915 deaths German geneticists 19th-century German biologists Foreign associates of the National Academy of Sciences German Roman Catholics

Work

References

Further reading

External links