TC-1827 is an
orally active, selective
agonist of the
α4β2 nicotinic receptors. Administration of TC-1827 improved memory and learning in a variety in rodents, and increased
long-term potentiation
In neuroscience, long-term potentiation (LTP) is a persistent strengthening of synapses based on recent patterns of activity. These are patterns of synaptic activity that produce a long-lasting increase in signal transmission between two neurons ...
in
hippocampal
The hippocampus (via Latin from Greek , 'seahorse') is a major component of the brain of humans and other vertebrates. Humans and other mammals have two hippocampi, one in each side of the brain. The hippocampus is part of the limbic system, an ...
slices. In addition, the compound was without significant cardiovascular side effects, except for a small, transient rise in
arterial blood pressure
Blood pressure (BP) is the pressure of circulating blood against the walls of blood vessels. Most of this pressure results from the heart pumping blood through the circulatory system. When used without qualification, the term "blood pressure" r ...
. The pro-cognitive effects of TC-1827 last much longer than the short half life (0.2 - 1.0 hours) would suggest.
References
{{Nicotinic acetylcholine receptor modulators
Nicotinic agonists
Nootropics
Pyrimidines