Succinylation is a
posttranslational modification
Post-translational modification (PTM) is the covalent and generally enzymatic modification of proteins following protein biosynthesis. This process occurs in the endoplasmic reticulum and the golgi apparatus. Proteins are synthesized by ribo ...
where a
succinyl group (-CO-CH
2-CH
2-CO
2H) is added to a
lysine residue of a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
molecule. This modification is found in many proteins, including
histones
In biology, histones are highly basic proteins abundant in lysine and arginine residues that are found in eukaryotic cell nuclei. They act as spools around which DNA winds to create structural units called nucleosomes. Nucleosomes in turn ar ...
.
The potential role of succinylation is under investigation, but as addition of succinyl group changes lysine's charge from +1 to −1 (at physiological pH) and introduces a relatively large structural moiety (100 Da), bigger than
acetylation (42 Da) or
methylation (14 Da), it is expected to lead to more significant changes in protein structure and function.
By analogy to
acetylation, it has been suggested that
succinyl-CoA
Succinyl-coenzyme A, abbreviated as succinyl-CoA () or SucCoA, is a thioester of succinic acid and coenzyme A.
Sources
It is an important intermediate in the citric acid cycle, where it is synthesized from α-ketoglutarate by α-ketoglutarate d ...
is the
cofactor of enzyme-mediated lysine succinylation.
References
External links
Succinylation, Yet A Novel PTM Pathway for Biological Regulation, But Ready to Be InvestigatedSuccinyl group at ChEBIThe dawn of succinylation: a posttranslational modification.
{{Posttranslational modification
Post-translational modification