Stanley Benjamin Prusiner (born May 28, 1942) is an American

neurologist Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal c ...

and

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological ch ...

. He is the director of the Institute for Neurodegenerative Diseases at

University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It ...

(UCSF). Prusiner discovered

prion Prions are misfolded proteins that have the ability to transmit their misfolded shape onto normal variants of the same protein. They characterize several fatal and transmissible neurodegenerative diseases in humans and many other animals. It i ...

s, a class of infectious self-reproducing

pathogen In biology, a pathogen ( el, πάθος, "suffering", "passion" and , "producer of") in the oldest and broadest sense, is any organism or agent that can produce disease. A pathogen may also be referred to as an infectious agent, or simply a g ...

s primarily or solely composed of

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...

. He received the

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 5 ...

in 1994 and the

Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, accordi ...

in 1997 for prion research developed by him and his team of experts (David E. Garfin, D. P. Stites, W. J. Hadlow, C. W. Eklund) beginning in the early 1970s.

Early life, career and research

He was born in

Des Moines, Iowa Des Moines () is the capital and the most populous city in the U.S. state of Iowa. It is also the county seat of Polk County. A small part of the city extends into Warren County. It was incorporated on September 22, 1851, as Fort Des Moine ...

, to Miriam (Spigel) and Lawrence Prusiner, an architect. He spent his childhood in Des Moines and

Cincinnati, Ohio Cincinnati ( ) is a city in the U.S. state of Ohio and the county seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line w ...

, where he attended

Walnut Hills High School , streetaddress = 3250 Victory Parkway , city = Cincinnati , state = Ohio , zipcode = 45207 , country = United States , coordinates = , type ...

, where he was known as "the little genius" for his groundbreaking work on a repellent for Boxelder bugs. Prusiner received a

Bachelor of Arts Bachelor of arts (BA or AB; from the Latin ', ', or ') is a bachelor's degree awarded for an undergraduate program in the arts, or, in some cases, other disciplines. A Bachelor of Arts degree course is generally completed in three or four yea ...

degree in

chemistry Chemistry is the scientific study of the properties and behavior of matter. It is a natural science that covers the elements that make up matter to the compounds made of atoms, molecules and ions: their composition, structure, proper ...

from the

University of Pennsylvania The University of Pennsylvania (also known as Penn or UPenn) is a Private university, private research university in Philadelphia. It is the fourth-oldest institution of higher education in the United States and is ranked among the highest- ...

and later received his M.D. from the University of Pennsylvania School of Medicine. Prusiner then completed an

internship An internship is a period of work experience offered by an organization for a limited period of time. Once confined to medical graduates, internship is used practice for a wide range of placements in businesses, non-profit organizations and gover ...

in medicine at the University of California, San Francisco. Later Prusiner moved to the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...

, where he studied glutaminases in '' E. coli'' in the laboratory of Earl Stadtman. After three years at NIH, Prusiner returned to UCSF to complete a

residency Residency may refer to: * Domicile (law), the act of establishing or maintaining a residence in a given place ** Permanent residency, indefinite residence within a country despite not having citizenship * Residency (medicine), a stage of postgrad ...

neurology Neurology (from el, νεῦρον (neûron), "string, nerve" and the suffix -logia, "study of") is the branch of medicine dealing with the diagnosis and treatment of all categories of conditions and disease involving the brain, the spinal ...

. Upon completion of the residency in 1974, Prusiner joined the faculty of the UCSF neurology department. Since that time, Prusiner has held various faculty and visiting faculty positions at both UCSF and

UC Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant uni ...

. Since 1999, Prusiner has been director of the Institute for Neurodegenerative Diseases research laboratory at UCSF, working on prion disease,

Alzheimer's disease Alzheimer's disease (AD) is a neurodegenerative disease that usually starts slowly and progressively worsens. It is the cause of 60–70% of cases of dementia. The most common early symptom is difficulty in remembering recent events. As ...

and tauopathies.

Awards and honors

Stanley Prusiner won the Nobel Prize in Physiology or Medicine in 1997 for his work in proposing an explanation for the cause of

bovine spongiform encephalopathy Bovine spongiform encephalopathy (BSE), commonly known as mad cow disease, is an incurable and invariably fatal neurodegenerative disease of cattle. Symptoms include abnormal behavior, trouble walking, and weight loss. Later in the course of t ...

("mad cow disease") and its human equivalent,

Creutzfeldt–Jakob disease Creutzfeldt–Jakob disease (CJD), also known as subacute spongiform encephalopathy or neurocognitive disorder due to prion disease, is an invariably fatal degenerative brain disorder. Early symptoms include memory problems, behavioral changes ...

. In this work, he coined the term ''prion'', which comes from the words "proteinaceous" and "infectious," in 1982 to refer to a previously undescribed form of infection due to protein misfolding. Prusiner was elected to the

National Academy of Science The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Natio ...

in 1992 and to its governing council in 2007. He is also an elected member of

the American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, ...

(1993), a Foreign Member of the Royal Society (ForMemRS) in 1997, and the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

(1998), the

Serbian Academy of Sciences and Arts The Serbian Academy of Sciences and Arts ( la, Academia Scientiarum et Artium Serbica, sr-Cyr, Српска академија наука и уметности, САНУ, Srpska akademija nauka i umetnosti, SANU) is a national academy and the ...

(2003), and the

Institute of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, Eng ...

. *

Potamkin Prize The Potamkin Prize for Research in Pick's, Alzheimer's, and Related Diseases was established in 1988 and is sponsored by the American Academy of Neurology. The prize is funded through the philanthropy of the Potamkin Foundation. The prize is awarded ...

for Alzheimer's Disease Research from the American Academy of Neurology (1991) * The

Richard Lounsbery Award The Richard Lounsbery Award is given to American and French scientists, 45 years or younger, in recognition of "extraordinary scientific achievement in biology and medicine." The Award alternates between French and American scientists, and is a ...

for Extraordinary Scientific Research in Biology and Medicine from the National Academy of Sciences (1993) *

Dickson Prize The Dickson Prize in Medicine and the Dickson Prize in Science were both established in 1969 by Joseph Z. Dickson and Agnes Fischer Dickson. Dickson Prize in Medicine The Dickson Prize in Medicine is awarded annually by the University of Pittsburg ...

(1993) * The Gairdner Foundation International Award (1993) * The

(1994) * The

Paul Ehrlich and Ludwig Darmstaedter Prize The Paul Ehrlich and Ludwig Darmstaedter Prize is an annual award bestowed by the since 1952 for investigations in medicine. It carries a prize money of 120,000 Euro. The prize awarding ceremony is traditionally held on March 14, the birthday of N ...

from the Federal Republic of Germany (1995) * The

Wolf Prize in Medicine The Wolf Prize in Medicine is awarded annually by the Wolf Foundation in Israel. It is one of the six Wolf Prizes established by the Foundation and awarded since 1978; the others are in Agriculture, Chemistry, Mathematics, Physics and Arts. The ...

from the

Wolf Foundation The Wolf Foundation is a private not-for-profit organization in Israel established in 1975 by Ricardo Wolf, a German-born Jewish Cuban inventor and former Cuban ambassador to Israel. Ricardo Wolf Ricardo Wolf, the founder of the Wolf Foundat ...

State of Israel Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated ...

(1996) * Grand Prix Charles-Leopold Mayer (1996) * The Keio International Award for Medical Science (1996) * Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...

(1996) * The

Louisa Gross Horwitz Prize The Louisa Gross Horwitz Prize for Biology or Biochemistry is an annual prize awarded by Columbia University to a researcher or group of researchers who have made an outstanding contribution in basic research in the fields of biology or biochemis ...

from

Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...

(1997) * The

(1997) * The Benjamin Franklin Medal from the

Franklin Institute The Franklin Institute is a science museum and the center of science education and research in Philadelphia, Pennsylvania. It is named after the American scientist and statesman Benjamin Franklin. It houses the Benjamin Franklin National Memori ...

(1998) * Honorary Doctorate from CEU Cardinal Herrera University (2005) * The

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

(2010)

References

External links

* {{DEFAULTSORT:Prusiner, Stanley B. 1942 births Living people Nobel laureates in Physiology or Medicine American Nobel laureates Richard-Lounsbery Award laureates American biochemists Foreign Members of the Royal Society Jewish American scientists Jewish chemists Jewish physicians Members of the United States National Academy of Sciences Members of the Serbian Academy of Sciences and Arts Prions University of California, San Francisco faculty University of California, San Francisco alumni Perelman School of Medicine at the University of Pennsylvania alumni Wolf Prize in Medicine laureates People from Des Moines, Iowa Recipients of the Albert Lasker Award for Basic Medical Research Howard Hughes Medical Investigators Members of the American Philosophical Society Members of the National Academy of Medicine

Early life, career and research

Awards and honors

See also

References

External links