Solomon Halbert Snyder (born December 26, 1938) is an American

neuroscientist A neuroscientist (or neurobiologist) is a scientist who has specialised knowledge in neuroscience, a branch of biology that deals with the physiology, biochemistry, psychology, anatomy and molecular biology of neurons, neural circuits, and glial ...

who has made wide-ranging contributions to

neuropharmacology Neuropharmacology is the study of how drugs affect function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmac ...

and

neurochemistry Neurochemistry is the study of chemicals, including neurotransmitters and other molecules such as psychopharmaceuticals and neuropeptides, that control and influence the physiology of the nervous system. This particular field within neuroscienc ...

. He studied at

Georgetown University Georgetown University is a private research university in the Georgetown neighborhood of Washington, D.C. Founded by Bishop John Carroll in 1789 as Georgetown College, the university has grown to comprise eleven undergraduate and graduate ...

, and has conducted the majority of his research at the

Johns Hopkins School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...

. Many advances in

molecular neuroscience Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject covers topics such as molecular neuroanatomy, mechanisms of molecular signaling in ...

have stemmed from Snyder's identification of

receptors Receptor may refer to: *Sensory receptor, in physiology, any structure which, on receiving environmental stimuli, produces an informative nerve impulse *Receptor (biochemistry), in biochemistry, a protein molecule that receives and responds to a n ...

for

neurotransmitter A neurotransmitter is a signaling molecule secreted by a neuron to affect another cell across a synapse. The cell receiving the signal, any main body part or target cell, may be another neuron, but could also be a gland or muscle cell. Neu ...

s and drugs, and elucidation of the actions of psychotropic agents. He received the

Albert Lasker Award for Basic Medical Research The Albert Lasker Award for Basic Medical Research is one of the prizes awarded by the Lasker Foundation for a fundamental discovery that opens up a new area of biomedical science. The award frequently precedes a Nobel Prize in Medicine; almost 50 ...

in 1978 for his research on the

opioid receptor Opioid receptors are a group of inhibitory G protein-coupled receptors with opioids as ligands. The endogenous opioids are dynorphins, enkephalins, endorphins, endomorphins and nociceptin. The opioid receptors are ~40% identical to somatostatin ...

, and is one of the most highly cited researchers in the biological and biomedical sciences, with the highest

h-index The ''h''-index is an author-level metric that measures both the productivity and citation impact of the publications, initially used for an individual scientist or scholar. The ''h''-index correlates with obvious success indicators such as ...

in those fields for the years 1983–2002, and then from 2007–2019.

Biography

Personal life

Solomon Snyder was born on December 26, 1938, in

Washington D.C. ) , image_skyline = , image_caption = Clockwise from top left: the Washington Monument and Lincoln Memorial on the National Mall, United States Capitol, Logan Circle, Jefferson Memorial, White House, Adams Morgan, Na ...

He is one of five children. Snyder and his wife Elaine, who died in 2016, have two daughters and three grandchildren. He lives in

Baltimore Baltimore ( , locally: or ) is the most populous city in the U.S. state of Maryland, fourth most populous city in the Mid-Atlantic, and the 30th most populous city in the United States with a population of 585,708 in 2020. Baltimore was ...

Maryland Maryland ( ) is a state in the Mid-Atlantic region of the United States. It shares borders with Virginia, West Virginia, and the District of Columbia to its south and west; Pennsylvania to its north; and Delaware and the Atlantic Ocean t ...

Education and early career

Snyder attended

from 1955 to 1958 and received his M.D. degree from

Georgetown University School of Medicine Georgetown University School of Medicine, a medical school opened in 1851, is one of Georgetown University's five graduate schools. It is located on Reservoir Road in the Georgetown neighborhood of Washington, DC, adjacent to the University's ...

in 1962. After a

medical residency Residency or postgraduate training is specifically a stage of graduate medical education. It refers to a qualified physician (one who holds the degree of MD, DO, MBBS, MBChB), veterinarian ( DVM or VMD) , dentist ( DDS or DMD) or podiatrist ( ...

at the Kaiser Hospital in San Francisco, he served as a research associate from 1963 to 1965 at the

National Institutes of Health The National Institutes of Health, commonly referred to as NIH (with each letter pronounced individually), is the primary agency of the United States government responsible for biomedical and public health research. It was founded in the lat ...

, where he studied under Julius Axelrod. Snyder moved to the

Johns Hopkins University School of Medicine The Johns Hopkins University School of Medicine (JHUSOM) is the medical school of Johns Hopkins University, a private research university in Baltimore, Maryland. Founded in 1893, the School of Medicine shares a campus with the Johns Hopkins Hospi ...

to complete his residency in

psychiatry Psychiatry is the medical specialty devoted to the diagnosis, prevention, and treatment of mental disorders. These include various maladaptations related to mood, behaviour, cognition, and perceptions. See glossary of psychiatry. Initial p ...

from 1965 to 1968. He was appointed to the faculty there in 1966 as Assistant

Professor Professor (commonly abbreviated as Prof.) is an academic rank at universities and other post-secondary education and research institutions in most countries. Literally, ''professor'' derives from Latin as a "person who professes". Professo ...

of Pharmacology. In 1968 he was promoted to Associate Professor of Pharmacology and Psychiatry and in 1970 to Full Professor in both departments. His laboratory is noted for the use of receptor binding studies to characterize the actions of neurotransmitters and

psychoactive drug A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. ...

s. He is also known for his work identifying

for the major neurotransmitters in the

brain A brain is an organ (biology), organ that serves as the center of the nervous system in all vertebrate and most invertebrate animals. It is located in the head, usually close to the sensory organs for senses such as Visual perception, vision. I ...

, and in the process explaining the actions of psychoactive drugs, such as the blockade of dopamine receptors by

antipsychotic Antipsychotics, also known as neuroleptics, are a class of psychotropic medication primarily used to manage psychosis (including delusions, hallucinations, paranoia or disordered thought), principally in schizophrenia but also in a range of ...

medications. He has described novel neurotransmitters, such as the gases

nitric oxide Nitric oxide (nitrogen oxide or nitrogen monoxide) is a colorless gas with the formula . It is one of the principal oxides of nitrogen. Nitric oxide is a free radical: it has an unpaired electron, which is sometimes denoted by a dot in its ...

and

carbon monoxide Carbon monoxide ( chemical formula CO) is a colorless, poisonous, odorless, tasteless, flammable gas that is slightly less dense than air. Carbon monoxide consists of one carbon atom and one oxygen atom connected by a triple bond. It is the simpl ...

and the D-isomers of

amino acids Amino acids are organic compounds that contain both amino and carboxylic acid functional groups. Although hundreds of amino acids exist in nature, by far the most important are the alpha-amino acids, which comprise proteins. Only 22 alpha am ...

, including D-serine.

Later career

Snyder is University Distinguished Service Professor of

Neuroscience Neuroscience is the science, scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a Multidisciplinary approach, multidisciplinary science that combines physiology, an ...

Pharmacology Pharmacology is a branch of medicine, biology and pharmaceutical sciences concerned with drug or medication action, where a drug may be defined as any artificial, natural, or endogenous (from within the body) molecule which exerts a biochemica ...

, and

Psychiatry Psychiatry is the medical specialty devoted to the diagnosis, prevention, and treatment of mental disorders. These include various maladaptations related to mood, behaviour, cognition, and perceptions. See glossary of psychiatry. Initial p ...

at the Johns Hopkins University School of Medicine. In 1980, he founded the Department of Neuroscience, and served as its first director from 1980 to 2006. In 2006, the department was renamed as The Solomon H. Snyder Department of Neuroscience in his honor. Snyder is also the Director of Drug Discovery at the Lieber Institute for Brain Development in Baltimore, MD. In 1980, he served as the president of the

Society for Neuroscience The Society for Neuroscience (SfN) is a professional society, headquartered in Washington, DC, for basic scientists and physicians around the world whose research is focused on the study of the brain and nervous system. It is especially well kn ...

. He is also associate editor, ''

Proceedings of the National Academy of Sciences of the United States of America ''Proceedings of the National Academy of Sciences of the United States of America'' (often abbreviated ''PNAS'' or ''PNAS USA'') is a peer-reviewed multidisciplinary scientific journal. It is the official journal of the National Academy of Sc ...

''. He helped start the companies Nova Pharmaceuticals and Guilford Pharmaceuticals, and has been an active philanthropist. He is listed by the

Institute for Scientific Information The Institute for Scientific Information (ISI) was an academic publishing service, founded by Eugene Garfield in Philadelphia in 1956. ISI offered scientometric and bibliographic database services. Its specialty was citation indexing and analysi ...

as one of the 10 most-often cited

biologist A biologist is a scientist who conducts research in biology. Biologists are interested in studying life on Earth, whether it is an individual cell, a multicellular organism, or a community of interacting populations. They usually specialize ...

s and he also has the highest

of any living biologist.

Awards

(1978): In 1973, he co-discovered the

and later identified the existence of normally occurring opiate-like peptides in the brain. *

Wolf Prize The Wolf Prize is an international award granted in Israel, that has been presented most years since 1978 to living scientists and artists for ''"achievements in the interest of mankind and friendly relations among people ... irrespective of nati ...

(from the President of

Israel Israel (; he, יִשְׂרָאֵל, ; ar, إِسْرَائِيل, ), officially the State of Israel ( he, מְדִינַת יִשְׂרָאֵל, label=none, translit=Medīnat Yīsrāʾēl; ), is a country in Western Asia. It is situated ...

) (1983) * Golden Plate Award of the

American Academy of Achievement The American Academy of Achievement, colloquially known as the Academy of Achievement, is a non-profit educational organization that recognizes some of the highest achieving individuals in diverse fields and gives them the opportunity to meet ...

(1986) *

Bower Award The Franklin Institute Awards (or Benjamin Franklin Medal) is an American science and engineering award presented by the Franklin Institute, a science museum in Philadelphia. The Franklin Institute awards comprises the Benjamin Franklin Medals ...

of the

Franklin Institute The Franklin Institute is a science museum and the center of science education and research in Philadelphia, Pennsylvania. It is named after the American scientist and statesman Benjamin Franklin. It houses the Benjamin Franklin National Memori ...

(1992) *

National Medal of Science The National Medal of Science is an honor bestowed by the President of the United States to individuals in science and engineering who have made important contributions to the advancement of knowledge in the fields of behavioral and social scienc ...

(2003) *

Perl-UNC Prize The Perl-UNC Prize is awarded internationally in the field of neuroscience. Its purpose is two-fold: to recognize researchers for outstanding discoveries and seminal insights in neuroscience and to celebrate the strength of the neuroscience resea ...

(2006) *

Albany Medical Center Albany Medical Center (AMC) is the name of the umbrella organization over the Albany Medical Center Hospital and Albany Medical College in Albany, New York. Though the name Albany Medical Center referring to the two institutions on their shared ca ...

Prize in Medicine and Biomedical Research (2007) *

NAS Award in the Neurosciences The NAS Award in the Neurosciences is awarded by the U.S. National Academy of Sciences "in recognition of extraordinary contributions to progress in the fields of neuroscience, including neurochemistry, neurophysiology, neuropharmacology, develop ...

(2013) * He is the recipient of nine honorary doctorates and has been elected to honorific societies including the

US National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Natio ...

, the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

, and the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

Biography

Personal life

Education and early career

Later career

Awards

References

Further reading