Selepressin (

INN Inns are generally establishments or buildings where travelers can seek lodging, and usually, food and drink. Inns are typically located in the country or along a highway; before the advent of motorized transportation they also provided accommo ...

) (code name FE-202158), also known as Hgn(4),Orn( Hgn(4),Orn(isopropyl">iPr)(8).html" ;"title="isopropyl.html" ;"title="homoglutamine.html" ;"title="/nowiki>Phe(2),Ile(3), homoglutamine">Hgn(4),Orn(isopropyl">iPr)(8)">isopropyl.html" ;"title="homoglutamine.html" ;"title="/nowiki>Phe(2),Ile(3), homoglutamine">Hgn(4),Orn(isopropyl">iPr)(8)/nowiki>vasopressin) is a potent, highly selective, short-acting peptide full agonist of the vasopressin 1A receptor and structural analog, analog of vasopressin which was under development by Ferring Pharmaceuticals for the treatment of vasodilatory

hypotension Hypotension is low blood pressure. Blood pressure is the force of blood pushing against the walls of the arteries as the heart pumps out blood. Blood pressure is indicated by two numbers, the systolic blood pressure (the top number) and the dia ...

in septic shock. The Phase 2b/3 adaptive trial (SEPSIS-ACT) was terminated in February 2018 for futility. The trial was halted prior to the initiation of the arm for the highest dosing regimen of 5.0 ng/kg/min.

References

Peptides Vasopressin receptor agonists {{systemic-hormonal-drug-stub