Second Persian Empire may refer to either of two historical states:
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Parthian Empire
The Parthian Empire (), also known as the Arsacid Empire (), was a major Iranian political and cultural power in ancient Iran from 247 BC to 224 AD. Its latter name comes from its founder, Arsaces I, who led the Parni tribe in conque ...
, an ethnic Parthian state in ancient Iran lasting from 247 BCE to 224 CE, sometimes considered to be an iteration of Persia
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Sasanian Empire, its Persian successor from 224 CE to 651 CE
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