Salvinorin B methoxymethyl ether (2-''O''-methoxymethylsalvinorin B) is a semi-synthetic
analogue of the natural product
salvinorin A
Salvinorin A is the main active psychotropic molecule in ''Salvia divinorum''. Salvinorin A is considered a dissociative hallucinogen.
It is structurally distinct from other naturally occurring hallucinogens (such as DMT, psilocybin, an ...
used in scientific research.
It has a longer duration of action of around 2–3 hours, compared to less than 30 minutes for salvinorin A,
and has increased affinity and potency at the
κ-opioid receptor. It is made from
salvinorin B, which is most conveniently made from salvinorin A by
deacetylation.
The
crystal structure
In crystallography, crystal structure is a description of the ordered arrangement of atoms, ions or molecules in a crystalline material. Ordered structures occur from the intrinsic nature of the constituent particles to form symmetric patterns ...
reveals that the
methoxy group overlaps with the
acetyl group of salvinorin A, but with a different orientation.
Salvinorin B methoxymethyl ether has a
Ki of 0.60 nM at the κ opioid receptor,
and is around five times more potent than salvinorin A in animal studies, although it is still only half as potent as its stronger
homolog
In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of prima ...
salvinorin B ethoxymethyl ether (symmetry).
See also
*
Salvinorin B ethoxymethyl ether
*
RB-64
References
{{Opioidergics
Synthetic opioids
Dissociative drugs
3-Furyl compounds
Lactones
Ethers
Ketones
Kappa-opioid receptor agonists
Methyl esters