SRX246, also known as API-246, is a
small-molecule
Within the fields of molecular biology and pharmacology, a small molecule or micromolecule is a low molecular weight (≤ 1000 daltons) organic compound that may regulate a biological process, with a size on the order of 1 nm. Many drugs ar ...
,
centrally-active, highly-selective
vasopressin V1A receptor antagonist which is under investigation by Azevan Pharmaceuticals for the treatment of
affective
Affect, in psychology, refers to the underlying experience of feeling, emotion or mood.
History
The modern conception of affect developed in the 19th century with Wilhelm Wundt. The word comes from the German ''Gefühl'', meaning "feeling. ...
and
anger disorders.
It is an
azetidinone
A beta-lactam (β-lactam) ring is a four-membered lactam. A ''lactam'' is a cyclic amide, and ''beta''-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is ...
derivative, and was developed from LY-307174 as a lead compound.
A
phase II activity trial of the drug in the treatment of adults with
intermittent explosive disorder is ongoing.
It is also being studied for the treatment of
post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a mental and behavioral disorder that can develop because of exposure to a traumatic event, such as sexual assault, warfare, traffic collisions, child abuse, domestic violence, or other threats o ...
.
See also
*
List of investigational anxiolytics
This is a list of investigational anxiolytics, or anxiolytics that are currently under development for clinical use but are not yet approved. Chemical/generic names are listed first, with developmental code names, synonyms, and brand names in paren ...
*
ABT-436
*
Balovaptan
*
Nelivaptan
Nelivaptan (INN) (developmental codename SSR-149,415) is a selective, orally active, non-peptide vasopressin receptor antagonist selective for the V1B subtype. The drug had entered clinical trials for treatment of anxiety and depression. In J ...
*
TS-121
References
External links
Azevan Pharmaceuticals, Inc. - Clinical CandidatesSRX-246 - AdisInsight
Lactams
Oxazolidines
Piperidines
Vasopressin receptor antagonists
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